Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Amy B. Jakowski"'
Autor:
Vincent Bernardo, Chunyan Su, Kenneth E. Hook, Konstantinos Tsaparikos, Amy B. Jakowski, Joel T. Arcari, Jitesh P. Jani, Bruce D. Cohen, James G. Christensen, Kwansik Yoon, John Jakubczak, Samit Kumar Bhattacharya, Erling Emerson, Leslie R. Pustilnik, James D. Moyer, Gerrit Los, Kevin Coleman, Stefan J. Steyn, David Briere, Ann Marie Rossi, Donn G. Wishka, Ingrid M. Pruimboom-Brees
Publikováno v:
Molecular Cancer Therapeutics. 9:883-894
The Aurora family of highly related serine/threonine kinases plays a key role in the regulation of mitosis. Aurora1 and Aurora2 play important but distinct roles in the G2 and M phases of the cell cycle and are essential for proper chromosome segrega
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ca0caffe1715249f06b2c07ecd0e448
https://doi.org/10.1158/1535-7163.mct-09-0915
https://doi.org/10.1158/1535-7163.mct-09-0915
Autor:
Amy B. Jakowski, F. David Tingley, Amy C. Shen, Michael R. Elwell, Steven B. Sands, Jenny Hon Cai, Martin Finkelstein, Dominique Brees
Publikováno v:
Toxicologic Pathology. 36:568-575
In a two-year carcinogenicity study with administration of high doses of the partial nicotinic agonist varenicline (recently approved for smoking cessation), mediastinal hibernomas occurred in three male rats. To investigate potential mechanisms for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf654145518842d89ea4bfe52f352b95
https://doi.org/10.1177/0192623308317424
https://doi.org/10.1177/0192623308317424
Autor:
Michael J. Goedken, George L. Scheffer, Sarah N. Barnes, Lisa M. Augustine, Nathan J. Cherrington, Amy B. Jakowski, José E. Manautou, Lauren M. Aleksunes, Ingrid M. Pruimboom-Brees
Publikováno v:
Drug Metabolism and Disposition. 35:1963-1969
Alterations in transporter expression may represent a compensatory mechanism of damaged hepatocytes to reduce accumulation of potentially toxic compounds. The present study was conducted to investigate the expression of hepatobiliary efflux transport
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b342c9792a1ac2961e4509cf608ad44
https://doi.org/10.1124/dmd.107.016170
https://doi.org/10.1124/dmd.107.016170
Autor:
George L. Scheffer, Ingrid M. Pruimboom-Brees, José E. Manautou, Amy B. Jakowski, Lauren M. Aleksunes
Publikováno v:
Toxicological Sciences. 89:370-379
Following acute chemical injury, hepatocytes are generally more resistant to toxicant re-exposure. Alterations in expression of hepatobiliary transport systems may contribute to this resistance by preventing accumulation of potentially toxic chemical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8c512066b99c97c04f0658b9566dab2
https://doi.org/10.1093/toxsci/kfi332
https://doi.org/10.1093/toxsci/kfi332
Publikováno v:
Biochemical and biophysical research communications. 412(3)
A critical unmet need exists for methods to quantitatively measure endogenous pancreatic β-cell mass (BCM) for the clinical evaluation of therapies to prevent or reverse loss of BCM and diabetes progression. Our objective was to identify G-protein c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e48a979b6623bedd476c5725eb70973
https://pubmed.ncbi.nlm.nih.gov/21820405
https://pubmed.ncbi.nlm.nih.gov/21820405
Publikováno v:
Drug-Induced Mitochondrial Dysfunction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3074bb7fe0e685d7f8b212ac7bc54251
https://doi.org/10.1002/9780470372531.ch22
https://doi.org/10.1002/9780470372531.ch22
Publikováno v:
Toxicologic pathology. 24(5)
In preclinical safety studies in which the administration of a test compound causes reductions in food consumption, body weights, and organ weights, it may be difficult to differentiate direct compound-induced effects on organ weights from those simp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6750290163c38bb05c8102f28d8c7ddf
https://pubmed.ncbi.nlm.nih.gov/8923686
https://pubmed.ncbi.nlm.nih.gov/8923686
Publikováno v:
Fundamental and applied toxicology : official journal of the Society of Toxicology. 21(2)
Tapetal Effect of an Azalide Antibiotic Following Oral Administration in Beagle Dogs. Fortner, J. H., Milisen, W. B., Lundeen, G. R., Jakowski, A. B., and Marsh, P.M. (1993). Fundam. Appl. Toxicol. 21, 164-173. An azalide antibiotic (CP-62,993) was a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d842a907254057dae85eece7cb09079
https://pubmed.ncbi.nlm.nih.gov/8405779
https://pubmed.ncbi.nlm.nih.gov/8405779
Publikováno v:
Proceedings, annual meeting, Electron Microscopy Society of America. 50:664-665
The tapetum lucidum is a reflective layer that lies beneath part of the retina in the eyes of many animals. It is believed to enhance night vision by reflecting light onto the sensory cells of the retina. Primates, including humans, do not have a tap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::66ec28ec03af602868a5b8df5d0ad944
https://doi.org/10.1017/s0424820100123726
https://doi.org/10.1017/s0424820100123726