Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Amy Andreotti"'
Publikováno v:
eLife, Vol 9 (2020)
Bruton’s tyrosine kinase (BTK) is targeted in the treatment of B-cell disorders including leukemias and lymphomas. Currently approved BTK inhibitors, including Ibrutinib, a first-in-class covalent inhibitor of BTK, bind directly to the kinase activ
Externí odkaz:
https://doaj.org/article/a1e7c59bd7424b1ea7e5693fd82af544
Publikováno v:
Journal of Biological Chemistry. 299:104100
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::62c643f3cae0e954815a2a7886682f16
https://doi.org/10.1016/j.jbc.2023.104100
https://doi.org/10.1016/j.jbc.2023.104100
Publikováno v:
Journal of Biological Chemistry. 299:103280
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::56b00867505b89a3d6e85f571f3d9202
https://doi.org/10.1016/j.jbc.2023.103280
https://doi.org/10.1016/j.jbc.2023.103280
Autor:
Alyssa Berthelette, Nilima Kolli, Neha Amatya, Amy Andreotti, Leslie Berg, Joonsoo Kang, Andrea Reboldi
Publikováno v:
The Journal of Immunology. 204:91.7-91.7
Ibrutinib is a covalent inhibitor that binds to the Bruton’s tyrosine kinase (BTK) ATP-dependent active site and it is currently used for treating a variety of B cell tumors. A high rate of drug resistance develops in Ibrutinib-treated patients thr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a7d38742eb15a472c53a3e300a386f0d
https://doi.org/10.4049/jimmunol.204.supp.91.7
https://doi.org/10.4049/jimmunol.204.supp.91.7
Publikováno v:
The Journal of Immunology. 194:134.15-134.15
Precise regulation of the kinetics and magnitude of Ca2+ signaling enables this signal to mediate diverse responses, such as cell migration, differentiation, vesicular trafficking, and cell death. Here, we showed that the Ca2+-binding protein calmodu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6105a558b5fc472d324c80d486cc9eb9
https://doi.org/10.4049/jimmunol.194.supp.134.15
https://doi.org/10.4049/jimmunol.194.supp.134.15
Autor:
Yina Huang, Xinxin Wang, Scott Boyken, Jiancheng Hu, Xiaolu Xu, Hani Suleiman, Madeline Shea, Andrey Shaw, Amy Andreotti
Publikováno v:
The Journal of Immunology. 190:50.1-50.1
The Tec family tyrosine kinase Itk is an important transducer of T cell activating signals. Itk regulates the levels of two second messengers Ca2+ and diacylglycerol, which are required for initiating transcriptional programs important for T cell pri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e49eba2eb1507db3d8bb011c31687f30
https://doi.org/10.4049/jimmunol.190.supp.50.1
https://doi.org/10.4049/jimmunol.190.supp.50.1