Zobrazeno 1 - 10
of 87
pro vyhledávání: '"Amy A. Pasquinelli"'
Autor:
Laura B Chipman, San Luc, Ian A Nicastro, Jesse J Hulahan, Delaney C Dann, Devavrat M Bodas, Amy E Pasquinelli
Publikováno v:
PLoS Genetics, Vol 19, Iss 11, p e1011055 (2023)
MicroRNAs (miRNAs) regulate gene expression by base-pairing to target sequences in messenger RNAs (mRNAs) and recruiting factors that induce translational repression and mRNA decay. In animals, nucleotides 2-8 at the 5' end of the miRNA, called the s
Externí odkaz:
https://doaj.org/article/79fbd3969f70495db760f99d1136f56c
Autor:
Corrina R. Elder, Amy E. Pasquinelli
Publikováno v:
Frontiers in Aging, Vol 3 (2022)
The use of Caenorhabditis elegans as a model organism in aging research has been integral to our understanding of genes and pathways involved in this process. Several well-conserved signaling pathways that respond to insulin signaling, diet, and assa
Externí odkaz:
https://doaj.org/article/03c29642105c42f187d3c46d9e4e0906
Publikováno v:
PLoS Genetics, Vol 17, Iss 8, p e1009734 (2021)
The heat shock response (HSR) is a highly conserved cellular process that promotes survival during stress. A hallmark of the HSR is the rapid induction of heat shock proteins (HSPs), such as HSP-70, by transcriptional activation. Once the stress is a
Externí odkaz:
https://doaj.org/article/4925b37160fc4debb8af21e5912cd790
Publikováno v:
eLife, Vol 8 (2019)
Heat Shock Factor 1 (HSF-1) is a key regulator of the heat shock response (HSR). Upon heat shock, HSF-1 binds well-conserved motifs, called Heat Shock Elements (HSEs), and drives expression of genes important for cellular protection during this stres
Externí odkaz:
https://doaj.org/article/51a8ef5c3f8143ca8b1b50910b81b7ec
Publikováno v:
Nucleic Acids Research. 50:4685-4702
The poly(A)-tail appended to the 3′-end of most eukaryotic transcripts plays a key role in their stability, nuclear transport, and translation. These roles are largely mediated by Poly(A) Binding Proteins (PABPs) that coat poly(A)-tails and interac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e6b076a5f77a1ca821fc4b31bffe7be
https://doi.org/10.1093/nar/gkac263
https://doi.org/10.1093/nar/gkac263
Autor:
Antti P Aalto, Ian A Nicastro, James P Broughton, Laura B Chipman, William P Schreiner, Jerry S Chen, Amy E Pasquinelli
Publikováno v:
PLoS Genetics, Vol 14, Iss 6, p e1007379 (2018)
Argonaute (AGO) proteins partner with microRNAs (miRNAs) to target specific genes for post-transcriptional regulation. During larval development in Caenorhabditis elegans, Argonaute-Like Gene 1 (ALG-1) is the primary mediator of the miRNA pathway, wh
Externí odkaz:
https://doaj.org/article/ad23563c739c482fa2fcb1cd2fc9bc5c
Autor:
Jacob M Garrigues, Amy E Pasquinelli
Publikováno v:
G3 Genes|Genomes|Genetics. 12
Transposable elements are powerful agents of evolution that can diversify transcriptional programs by distributing transcription factor DNA-binding sites throughout genomes. To investigate the extent that transposable elements provide transcription f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::343430219a68e0cda123fc0eb8a4ea61
https://doi.org/10.1093/g3journal/jkac009
https://doi.org/10.1093/g3journal/jkac009
Autor:
William P. Schreiner, Jacob M. Garrigues, Jerry S. Chen, Amy E. Pasquinelli, Delaney C Pagliuso, Antti P. Aalto
Publikováno v:
Schreiner, W P, Pagliuso, D C, Garrigues, J M, Chen, J S, Aalto, A P & Pasquinelli, A E 2019, ' Remodeling of the Caenorhabditis elegans non-coding RNA transcriptome by heat shock ', Nucleic Acids Research, vol. 47, no. 18, pp. 9829-9841 . https://doi.org/10.1093/nar/gkz693
Nucleic Acids Research
Nucleic Acids Research
Elevated temperatures activate a heat shock response (HSR) to protect cells from the pathological effects of protein mis-folding, cellular mis-organization, organelle dysfunction and altered membrane fluidity. This response includes activation of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a534a945da38aaace72fdeafe4f49e1
https://doi.org/10.1093/nar/gkz693
https://doi.org/10.1093/nar/gkz693
Autor:
Shaun E Hunter, Emily F Finnegan, Dimitrios G Zisoulis, Michael T Lovci, Katya V Melnik-Martinez, Gene W Yeo, Amy E Pasquinelli
Publikováno v:
PLoS Genetics, Vol 9, Iss 3, p e1003353 (2013)
The let-7 microRNA (miRNA) regulates cellular differentiation across many animal species. Loss of let-7 activity causes abnormal development in Caenorhabditis elegans and unchecked cellular proliferation in human cells, which contributes to tumorigen
Externí odkaz:
https://doaj.org/article/9e79cabe4df8400b9a6000926f1efd08
Publikováno v:
PLoS Genetics, Vol 8, Iss 3, p e1002536 (2012)
RNA interference (RNAi) utilizes small interfering RNAs (siRNAs) to direct silencing of specific genes through transcriptional and post-transcriptional mechanisms. The siRNA guides can originate from exogenous (exo-RNAi) or natural endogenous (endo-R
Externí odkaz:
https://doaj.org/article/80d02ae7542c4b3c8449b8d95dfeff4c