Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Amy, Pointon"'
Autor:
Chrysa Koukorava, Katie Ahmed, Shrouq Almaghrabi, Amy Pointon, Malcolm Haddrick, Michael J. Cross
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 11 (2024)
Cardiotoxicity can be defined as “chemically induced heart disease”, which can occur with many different drug classes treating a range of diseases. It is the primary cause of drug attrition during pre-clinical development and withdrawal from the
Externí odkaz:
https://doaj.org/article/c3681278cd7d4cbe900884c98d199ba2
Autor:
Linda Starnes, Andrew Hall, Damla Etal, Anna-Lina Cavallo, Piotr Grabowski, John Gallon, Michelle Kha, Ryan Hicks, Amy Pointon
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 11 (2024)
Creation of disease models utilizing hiPSCs in combination with CRISPR/Cas9 gene editing enable mechanistic insights into differential pharmacological responses. This allows translation of efficacy and safety findings from a healthy to a diseased sta
Externí odkaz:
https://doaj.org/article/e132b887164947bbaa01aa31e0c55474
Autor:
Tara J. Bowen, Andrew D. Southam, Andrew R. Hall, Ralf J. M. Weber, Gavin R. Lloyd, Ruth Macdonald, Amanda Wilson, Amy Pointon, Mark R. Viant
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Untargeted metabolomics is an established approach in toxicology for characterising endogenous metabolic responses to xenobiotic exposure. Detecting the xenobiotic and its biotransformation products as part of the metabolomics analysis provi
Externí odkaz:
https://doaj.org/article/4910e9a54ea449d1b77c4b11d29fc8ec
Autor:
Tara J. Bowen, Andrew R. Hall, Gavin R. Lloyd, Ralf J. M. Weber, Amanda Wilson, Amy Pointon, Mark R. Viant
Publikováno v:
Metabolites, Vol 11, Iss 9, p 644 (2021)
Discovering modes of action and predictive biomarkers of drug-induced structural cardiotoxicity offers the potential to improve cardiac safety assessment of lead compounds and enhance preclinical to clinical translation during drug development. Cardi
Externí odkaz:
https://doaj.org/article/1fff1084419a4faa87cb1517e12c200b
Publikováno v:
Journal of Molecular and Cellular Cardiology. 173:167-169
Autor:
Christina Schindler, Andie Collinson, Carl Matthews, Amy Pointon, Lesley Jenkinson, Ralph R Minter, Tristan J Vaughan, Natalie J Tigue
Publikováno v:
PLoS ONE, Vol 14, Iss 3, p e0214545 (2019)
Doxorubicin is a chemotherapeutic agent that is commonly used to treat a broad range of cancers. However, significant cardiotoxicity, associated with prolonged exposure to doxorubicin, limits its continued therapeutic use. One strategy to prevent the
Externí odkaz:
https://doaj.org/article/d2a3717382b14d8298b565839ea17c6b
Autor:
Hongbin Yang, Olga Obrezanova, Amy Pointon, Will Stebbeds, Jo Francis, Kylie A. Beattie, Peter Clements, James S. Harvey, Graham F. Smith, Andreas Bender
Publikováno v:
Toxicology and applied pharmacology. 459
Functional changes to cardiomyocytes are undesirable during drug discovery and identifying the inotropic effects of compounds is hence necessary to decrease the risk of cardiovascular adverse effects in the clinic. Recently, approaches leveraging cal
Autor:
Nicolas Couvreur, Charles Benson, Jean-Michel Guillon, Yoshiko Okai, Armando Lagrutta, Todd Wisialowski, Michael G. Rolf, Ard Teisman, C. Michael Foley, Hugo M. Vargas, Jean-Pierre Valentin, Maki Ito, Michael J. Engwall, Khuram W. Chaudhary, Gary Gintant, David J. Gallacher, Takashi Yoshinaga, Andrea Greiter-Wilke, Corina Dota, Paul Levesque, Katsuyoshi Chiba, Amy Pointon, Stephen Jenkinson, Anthony Bahinski, Martin Traebert, Brian Guth, Eric Martel, Alan S. Bass, Christa Hegele‐Hartung, William E. Achanzar, Ravikumar Peri, Herbert M. Himmel, Yusheng Qu, Derek J. Leishman
Publikováno v:
Clinical Pharmacology and Therapeutics
Defining an appropriate and efficient assessment of drug‐induced corrected QT interval (QTc) prolongation (a surrogate marker of torsades de pointes arrhythmia) remains a concern of drug developers and regulators worldwide. In use for over 15 years
Publikováno v:
Drug Discovery Today. 25:1129-1134
Our goal is to accurately predict all types of cardiovascular events in patients utilising nonclinical cardiovascular safety data. In the past two decades, cardiovascular safety science has primarily focused on events associated with the electrocardi
Autor:
Jean-Pierre Valentin, Daniel P. Russo, David T. Szabo, Lidiya Stavitskaya, Patricia Ruiz, Craig Zwickl, Louise Neilson, Vinicius M. Alves, Candice Johnson, Andreas Bender, Arianna Bassan, Lennart T. Anger, Reena Sandhu, David Woolley, Lisa Beilke, Manuela Pavan, Raymond Kemper, Mark T. D. Cronin, Moiz Mumtaz, Glenn J. Myatt, Alexander Amberg, Yogesh Sabnis, Jui-Hua Hsieh, Markus Schaefer, Amy Pointon, Autumn Bernal, Julia Pletz
Publikováno v:
Comput Toxicol
The kidneys, heart and lungs are vital organ systems evaluated as part of acute or chronic toxicity assessments. New methodologies are being developed to predict these adverse effects based on in vitro and in silico approaches. This paper reviews the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e41082bb951a3c41285999b6f292588
https://europepmc.org/articles/PMC9205464/
https://europepmc.org/articles/PMC9205464/