Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Amy, Monaghan"'
Autor:
Magda L Atilano, Sebastian Grönke, Teresa Niccoli, Liam Kempthorne, Oliver Hahn, Javier Morón-Oset, Oliver Hendrich, Miranda Dyson, Mirjam Lisette Adams, Alexander Hull, Marie-Therese Salcher-Konrad, Amy Monaghan, Magda Bictash, Idoia Glaria, Adrian M Isaacs, Linda Partridge
Publikováno v:
eLife, Vol 10 (2021)
G4C2 repeat expansions within the C9orf72 gene are the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The repeats undergo repeat-associated non-ATG translation to generate toxic dipeptide repeat pr
Externí odkaz:
https://doaj.org/article/55824973121a40c69b33db796ae2c8b6
Autor:
Amy Monaghan, Paul Whiting, James Hillier, Svend Kjaer, Reinis R. Ruza, Jean-Paul Vincent, S. Frew, Paul V. Fish, L. Vecchia, William Mahy, James Sipthorp, Fredrik Svensson, Nicky J. Willis, Magda Bictash, Hannah Woodward, Patricia C. Salinas, Yuguang Zhao, E. Yvonne Jones
Publikováno v:
Journal of Medicinal Chemistry. 63:12942-12956
Carboxylesterase Notum is a negative regulator of the Wnt signaling pathway. There is an emerging understanding of the role Notum plays in disease, supporting the need to discover new small-molecule inhibitors. A crystallographic X-ray fragment scree
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::deae46cf90f6f7beda225afadafa1e17
https://doi.org/10.1021/acs.jmedchem.0c01391
https://doi.org/10.1021/acs.jmedchem.0c01391
Autor:
Nicky Willis, William Mahy, James Sipthorp, Yuguang Zhao, Hannah Woodward, Benjamin Atkinson, Elliott Bayle, Fredrik Svensson, Sarah Frew, Fiona Jeganathan, Amy Monaghan, Stefano Benvegnu, Sarah Jolly, Luca Vecchia, Reinis Ruza, Svend Kjaer, Steven Howell, Ambrosius Snidjers, Magda Bictash, Patricia Salinas, Jean-Paul Vincent, Yvonne Jones, Paul Whiting, Paul Fish
Notum is a carboxylesterase that suppresses Wnt signaling through deacylation of an essential palmitoleate group on Wnt proteins. There is a growing understanding of the role Notum plays in human disease such as colorectal cancer and Alzheimer’s di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8addc522ec8ef944de3c1786ccffb9ca
https://doi.org/10.26434/chemrxiv-2022-f05w8
https://doi.org/10.26434/chemrxiv-2022-f05w8
Autor:
Nicky J. Willis, William Mahy, James Sipthorp, Yuguang Zhao, Hannah L. Woodward, Benjamin N. Atkinson, Elliott D. Bayle, Fredrik Svensson, Sarah Frew, Fiona Jeganathan, Amy Monaghan, Stefano Benvegnù, Sarah Jolly, Luca Vecchia, Reinis R. Ruza, Svend Kjær, Steven Howell, Ambrosius P. Snijders, Magda Bictash, Patricia C. Salinas, Jean-Paul Vincent, E. Yvonne Jones, Paul Whiting, Paul V. Fish
Notum is a carboxylesterase that suppresses Wnt signaling through deacylation of an essential palmitoleate group on Wnt proteins. There is a growing understanding of the role Notum plays in human diseases such as colorectal cancer and Alzheimer's dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3474b8ac04a0b606e41a67edadf62c69
Autor:
David Steadman, Benjamin N. Atkinson, Yuguang Zhao, Nicky J. Willis, Sarah Frew, Amy Monaghan, Chandni Patel, Emma Armstrong, Kathryn Costelloe, Lorenza Magno, Magda Bictash, E. Yvonne Jones, Paul V. Fish, Fredrik Svensson
Publikováno v:
Journal of medicinal chemistry. 65(1)
Notum is a negative regulator of Wnt signaling acting through the hydrolysis of a palmitoleoylate ester, which is required for Wnt activity. Inhibitors of Notum could be of use in diseases where dysfunctional Notum activity is an underlying cause. A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40edd35a69ac0b95580d171b01ebf3b1
https://pubmed.ncbi.nlm.nih.gov/34939789
https://pubmed.ncbi.nlm.nih.gov/34939789
Autor:
Oliver Hahn, Sebastian Grönke, Oliver Hendrich, Alexander Hull, Miranda C. Dyson, Adrian M. Isaacs, Idoia Glaria, Magda L. Atilano, Linda Partridge, Liam Kempthorne, Amy Monaghan, Javier Morón-Oset, Marie-Therese Salcher-Konrad, Teresa Niccoli, Magda Bictash, Mirjam Lisette Adams
Publikováno v:
Elife
eLife
eLife, Vol 10 (2021)
eLife
eLife, Vol 10 (2021)
G4C2 repeat expansions within the C9orf72 gene are the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The repeats undergo repeat-associated non-ATG translation to generate toxic dipeptide repeat pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::049e2373f4ec78a5ad540b032b74cbe5
https://hdl.handle.net/21.11116/0000-000A-FAE7-8
https://hdl.handle.net/21.11116/0000-000A-FAE7-8
Autor:
Linda Partridge, Alexander Hull, Miranda C. Dyson, Sebastian Grönke, Teresa Niccoli, Liam Kempthorne, Adrian M. Isaacs, Javier Morón-Oset, Magda L. Atilano, Marie-Therese Salcher-Konrad, Oliver Hendrich, Idoia Glaria, Amy Monaghan, Magda Bictash, Mirjam Lisette Adams, Oliver Hahn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e92b743f8f1c834c64d7ff5c15aac137
https://doi.org/10.7554/elife.58565.sa2
https://doi.org/10.7554/elife.58565.sa2
Autor:
William, Mahy, Nicky J, Willis, Yuguang, Zhao, Hannah L, Woodward, Fredrik, Svensson, James, Sipthorp, Luca, Vecchia, Reinis R, Ruza, James, Hillier, Svend, Kjær, Sarah, Frew, Amy, Monaghan, Magda, Bictash, Patricia C, Salinas, Paul, Whiting, Jean-Paul, Vincent, E Yvonne, Jones, Paul V, Fish
Publikováno v:
Journal of medicinal chemistry. 63(21)
Carboxylesterase Notum is a negative regulator of the Wnt signaling pathway. There is an emerging understanding of the role Notum plays in disease, supporting the need to discover new small-molecule inhibitors. A crystallographic X-ray fragment scree
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::07128c1ea3b73521973fe7fd4ebe3825
https://pubmed.ncbi.nlm.nih.gov/33124429
https://pubmed.ncbi.nlm.nih.gov/33124429
Autor:
Benjamin N. Atkinson, Paul V. Fish, David Steadman, Fredrik Svensson, James Hillier, Nicky J. Willis, A Costa, M Patel, Amy Monaghan, A Flint, Hannah Woodward, S. Frew, Reinis R. Ruza, William Mahy, M W Walter, D Papatheodorou, Magda Bictash, Yuguang Zhao, E Y Jones, L. Vecchia
Publikováno v:
Journal of medicinal chemistry. 63(17)
The Wnt family of proteins are secreted signaling proteins that play key roles in regulating cellular functions. Recently, carboxylesterase Notum was shown to act as a negative regulator of Wnt signaling by mediating the removal of an essential palmi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1490ab55dc83d203fbb243d97d8f076
https://pubmed.ncbi.nlm.nih.gov/32787107
https://pubmed.ncbi.nlm.nih.gov/32787107
Autor:
Benjamin N, Atkinson, David, Steadman, Yuguang, Zhao, James, Sipthorp, Luca, Vecchia, Reinis R, Ruza, Fiona, Jeganathan, Georgie, Lines, Sarah, Frew, Amy, Monaghan, Svend, Kjær, Magda, Bictash, E Yvonne, Jones, Paul V, Fish
Publikováno v:
MedChemComm
Optimization of fragment hit 3 identified isoquinoline 45 as a potent inhibitor of NOTUM with an unexpected flipped binding mode.
NOTUM is a carboxylesterase that has been shown to act by mediating the O-depalmitoleoylation of Wnt proteins resul
NOTUM is a carboxylesterase that has been shown to act by mediating the O-depalmitoleoylation of Wnt proteins resul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dbb625a59f2dade8bff75e1d10556061
https://pubmed.ncbi.nlm.nih.gov/31534655
https://pubmed.ncbi.nlm.nih.gov/31534655