Zobrazeno 1 - 10
of 166
pro vyhledávání: '"Amy, Leung"'
Autor:
Hali Sai, Bethany Ollington, Farah O. Rezek, Niuzheng Chai, Amelia Lane, Anastasios Georgiadis, James Bainbridge, Michel Michaelides, Almudena Sacristan-Reviriego, Pedro R.L. Perdigão, Amy Leung, Jacqueline van der Spuy
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 1, Pp 102148- (2024)
Biallelic variations in the aryl hydrocarbon receptor interacting protein-like 1 (AIPL1) gene cause Leber congenital amaurosis subtype 4 (LCA4), an autosomal recessive early-onset severe retinal dystrophy that leads to the rapid degeneration of retin
Externí odkaz:
https://doaj.org/article/b9beb1ebaa5940b7aa0820f78cbd3d1d
Autor:
Heon Shin, Amy Leung, Kevin R Costello, Parijat Senapati, Hiroyuki Kato, Roger E Moore, Michael Lee, Dimitri Lin, Xiaofang Tang, Patrick Pirrotte, Zhen Bouman Chen, Dustin E Schones
Publikováno v:
eLife, Vol 12 (2023)
The DNA methyltransferase activity of DNMT1 is vital for genomic maintenance of DNA methylation. We report here that DNMT1 function is regulated by O-GlcNAcylation, a protein modification that is sensitive to glucose levels, and that elevated O-GlcNA
Externí odkaz:
https://doaj.org/article/01fe54536d654e7bb305f7fb4ed7dac4
Autor:
Kevin R Costello, Amy Leung, Candi Trac, Michael Lee, Mudaser Basam, J Andrew Pospisilik, Dustin E Schones
Publikováno v:
eLife, Vol 10 (2021)
Transposable elements (TEs) are mobile genetic elements that make up a large fraction of mammalian genomes. While select TEs have been co-opted in host genomes to have function, the majority of these elements are epigenetically silenced by DNA methyl
Externí odkaz:
https://doaj.org/article/55ac6a019e3446ad92dcb3e7b15bda15
Autor:
Parijat Senapati, Hiroyuki Kato, Michael Lee, Amy Leung, Christine Thai, Angelica Sanchez, Emily J. Gallagher, Derek LeRoith, Victoria L. Seewaldt, David K. Ann, Dustin E. Schones
Publikováno v:
Epigenetics & Chromatin, Vol 12, Iss 1, Pp 1-15 (2019)
Abstract Background Hyperinsulinemia, the presence of excess insulin relative to glucose in the blood, is considered to be a poor prognostic indicator for patients with triple-negative breast cancer (TNBC). mTOR, a downstream effector of insulin, enh
Externí odkaz:
https://doaj.org/article/d7335b0fd4b044189496f088802659ef
Publikováno v:
Journal of Diabetes Research, Vol 2021 (2021)
Externí odkaz:
https://doaj.org/article/80daae1b53ad452fb73771a712e5d594
Publikováno v:
Journal of Diabetes Research, Vol 2020 (2020)
In response to the recent rise in numbers of diabetes patients, many treatments have been developed; but currently, oral antihyperglycemic agents and insulin are still the main clinical treatments. Since current drugs have limitations and harmful sid
Externí odkaz:
https://doaj.org/article/cb1e4451d6ae46ea81a6324d5cd4e5c0
Autor:
Kim Vanuytsel, Taylor Matte, Amy Leung, Zaw Htut Naing, Tasha Morrison, David H.K. Chui, Martin H. Steinberg, George J. Murphy
Publikováno v:
Blood Advances, Vol 2, Iss 15, Pp 1998-2011 (2018)
Abstract: Robust β-globin expression in erythroid cells derived from induced pluripotent stem cells (iPSCs) increases the resolution with which red blood cell disorders such as sickle cell disease and β thalassemia can be modeled in vitro. To bette
Externí odkaz:
https://doaj.org/article/90f65c6905b545d187d63ae96104ade0
Autor:
Amy Leung, Almudena Sacristan-Reviriego, Pedro R.L. Perdigão, Hali Sai, Michalis Georgiou, Angelos Kalitzeos, Amanda-Jayne F. Carr, Peter J. Coffey, Michel Michaelides, James Bainbridge, Michael E. Cheetham, Jacqueline van der Spuy
Publikováno v:
Stem Cell Reports. 17:2187-2202
Leber congenital amaurosis type 4 (LCA4), caused by AIPL1 mutations, is characterized by severe sight impairment in infancy and rapidly progressing degeneration of photoreceptor cells. We generated retinal organoids using induced pluripotent stem cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd48dd7e79bd2b59428b7b1ce5139f43
https://doi.org/10.1016/j.stemcr.2022.08.005
https://doi.org/10.1016/j.stemcr.2022.08.005
Autor:
Vishnu Amaram Samara, Sadhan Das, Marpadga A. Reddy, Vinay Singh Tanwar, Kenneth Stapleton, Amy Leung, Maryam Abdollahi, Rituparna Ganguly, Linda Lanting, Rama Natarajan
Publikováno v:
Cells, Vol 10, Iss 10, p 2696 (2021)
Long non-coding RNAs (lncRNAs) play key roles in Angiotensin II (AngII) signaling but their role in chondrogenic transformation of vascular smooth muscle cells (VSMCs) is unknown. We describe a novel AngII-induced lncRNA Alivec (Angiotensin II-induce
Externí odkaz:
https://doaj.org/article/bf30d0f40d4f4e429a491aaf3b6ff8e0
Autor:
Sadhan Das, Parijat Senapati, Zhuo Chen, Marpadga A. Reddy, Rituparna Ganguly, Linda Lanting, Varun Mandi, Anita Bansal, Amy Leung, Selena Zhang, Ye Jia, Xiwei Wu, Dustin E. Schones, Rama Natarajan
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-19 (2017)
The repertoire of tissue-specific distal regulators of gene transcription enhancers defines homeostasis or disease. Here, the authors reveal the enhancer and super-enhancer signature of vascular smooth muscle cells under normal and angiotensin II sti
Externí odkaz:
https://doaj.org/article/c12c799c38c64e36a32adeb8061e24ec