Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Amy, Gustafson"'
Autor:
KHAROUF, JACQUELINE
Publikováno v:
Fanfare: The Magazine for Serious Record Collectors. Jul/Aug2017, Vol. 40 Issue 6, p72-76. 5p.
Publikováno v:
INNOVATIONS in Pharmacy, Vol 12, Iss 2 (2021)
Objective: To evaluate a novel outpatient pharmacist consult service in a large academic medical center. Setting: Four outpatient pharmacies that are part of a large academic medical center Methods: An outpatient pharmacist consult order was crea
Externí odkaz:
https://doaj.org/article/efdf807231c24d13ba357945ff96274d
Autor:
Ke Sherry Li, John G. Quinn, Matthew J. Saabye, Jesus F. Salcido Guerrero, Jim Nonomiya, Qihui Lian, Wilson Phung, Yevgeniy Izrayelit, Benjamin T. Walters, Amy Gustafson, Nicholas F. Endres, Maureen H. Beresini, Melinda M. Mulvihill
Publikováno v:
Analytical Chemistry. 94:1230-1239
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::29bfe968fd4881356fdca488b3f19009
https://doi.org/10.1021/acs.analchem.1c04463
https://doi.org/10.1021/acs.analchem.1c04463
Autor:
Wen Liu, Amy Gustafson, Firoz Jaipuri, Erica VanderPorten, Leanne Goon, Yamin Zhang, Guosheng Wu, Zuhui Zhang, Antonio G. DiPasquale, Xiaokai Li, Angela J. Oh, Lewis J. Gazzard, Seth F. Harris, Jesse Waldo, Roheeth Kumar Pavana, Yichin Liu, Venkata Velvadapu, Cheng Shao, Yuen Po-Wai, Mario R. Mautino, Zhonghua Pei, Hank La, Hima Potturi, Georgette Castanedo, Benjamin D. Sellers, Kevin DeMent, Sanjeev Kumar, Richard Pastor, Rohan Mendonca, Brendan T. Parr
Publikováno v:
ACS Med Chem Lett
[Image: see text] A class of imidazoisoindole (III) heme-binding indoleamine-2,3-dioxygenase (IDO1) inhibitors were optimized via structure-based drug design into a series of tryptophan-2,3-dioxygenase (TDO)-selective inhibitors. Kynurenine pathway m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::701dd22f186bad66eefde1770830d8d6
https://doi.org/10.1021/acsmedchemlett.0c00004
https://doi.org/10.1021/acsmedchemlett.0c00004
Autor:
Yichin Liu, Peter S. Dragovich, Daniel F. Ortwine, Birong Zhang, Richard D. Cummings, Jun Liang, Yingqing Ran, Marie Classon, Sharada Labadie, Tommy Lai, Weifeng Mao, Victor S. Gehling, Bianca M. Liederer, Erica Van der Porten, Jean-Christophe Harmange, Till Mauer, Le An, Xiaoping Zheng, Jiangpeng Liao, James R. Kiefer, Maia Vinogradova, Snahel Patel, Patrick Trojer, Gauri Deshmukh, Amy Gustafson, Lesley J. Murray
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:2974-2981
A high-throughput screening (HTS) of the Genentech/Roche library identified a novel, uncharged scaffold as a KDM5A inhibitor. Lacking insight into the binding mode, initial attempts to improve inhibitor potency failed to improve potency, and synthesi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e55347996293ce1a7c7b826ca989d0ef
https://doi.org/10.1016/j.bmcl.2017.05.016
https://doi.org/10.1016/j.bmcl.2017.05.016
Publikováno v:
Innovations in Pharmacy
INNOVATIONS in Pharmacy, Vol 12, Iss 2 (2021)
INNOVATIONS in Pharmacy, Vol 12, Iss 2 (2021)
Objective: To evaluate a novel outpatient pharmacist consult service in a large academic medical center. Setting: Four outpatient pharmacies that are part of a large academic medical center Methods: An outpatient pharmacist consult order was created
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5e5668dedd05c54f1972fe997798133
https://doi.org/10.24926/iip.v12i2.3238
https://doi.org/10.24926/iip.v12i2.3238
Autor:
Yichin Liu, Xiaoping Zheng, Lesley J. Murray, Marie Classon, Birong Zhang, Erica Van der Porten, Amy Gustafson, Jiangpeng Liao, Maia Vinogradova, Jean-Christophe Harmange, Weifeng Mao, Bianca M. Liederer, Tommy Lai, Sharada Labadie, Patrick Trojer, Richard D. Cummings, Victor S. Gehling, Gauri Deshmukh, James R. Kiefer, Peter S. Dragovich, Daniel F. Ortwine, Jun Liang
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:4036-4041
Starting with a lead [1,5-a]pyrimidin-7(4H)-one-containing molecule (1), we generated potent, selective and orally bioavailable KDM5 inhibitors. Using structure- and property-based approaches, we designed 48 with improved cell potency (PC9 H3K4Me3 EC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ca2fc00b367f08650c72962e0d79153
https://doi.org/10.1016/j.bmcl.2016.06.078
https://doi.org/10.1016/j.bmcl.2016.06.078
Autor:
Dhireshan Gadiagellan, Amy Gustafson, Daniel P. Gross, Timothy D. Dawes, Till Maurer, Peter Thana, Linda Orren, Rebecca Turincio, Richard A. Rodriguez, Marya Liimatta, Maureen Beresini, Steven W. Jones, Kevin R Clark
Publikováno v:
SLAS Technology. 21:64-75
Acoustic droplet ejection (ADE) as a means of transferring library compounds has had a dramatic impact on the way in which high-throughput screening campaigns are conducted in many laboratories. Two Labcyte Echo ADE liquid handlers form the core of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d658af8557ba7ebd5063d796846694da
https://doi.org/10.1177/2211068215590588
https://doi.org/10.1177/2211068215590588
Autor:
Joachim Rudolph, Thomas Hunsaker, Christiaan Klijn, Christine Orr, Matthew R. Durk, Scott E. Martin, Dhara N. Amin, Mark Merchant, Frances Shanahan, Yihong Yu, Richard M. Neve, Xiaolin Zhang, Amy Gustafson, John Chan, Shiva Malek, Hank La, Eva Lin, Avinashnarayan Venkatanarayan, Ivana Yen, Scott A. Foster
Publikováno v:
Cancer cell. 34(4)
Targeting KRAS mutant tumors through inhibition of individual downstream pathways has had limited clinical success. Here we report that RAF inhibitors exhibit little efficacy in KRAS mutant tumors. In combination drug screens, MEK and PI3K inhibitors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ddade1c5e7ca4e5c18047266180c322
https://pubmed.ncbi.nlm.nih.gov/30300582
https://pubmed.ncbi.nlm.nih.gov/30300582
Autor:
Fabien Vincent, Michelle Dourado, Daniel Emerling, Luna Liu, Victor Yip, Margaret Nguyen, Zhi-Liang Wei, Zipfel Sheila, Candace Chi, Amy Gustafson, Jeff DeFalco, Michael G. Kelly, John Kincaid, Qingling Zhang, Donogh J R O'Mahony, Matthew A.J. Duncton, Alejandra Acevedo
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:4011-4015
Antagonists of the TRPV4 receptor were identified using a focused screen, followed by a limited optimization program. The leading compounds obtained from this exercise, RN-1665 23 and RN-9893 26, showed moderate oral bioavailability when dosed to rat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f53256b218e4196c4d5f87c151a03f04
https://doi.org/10.1016/j.bmcl.2015.06.098
https://doi.org/10.1016/j.bmcl.2015.06.098