Výsledky vyhledávání - "Amy, Goundry"

Akademický článek

Subtilisin of Leishmania amazonensis as Potential Druggable Target: Subcellular Localization, In Vitro Leishmanicidal Activity and Molecular Docking of PF-429242, a Subtilisin Inhibitor

Autor: Pollyanna Stephanie Gomes, Monique Pacheco Duarte Carneiro, Patrícia de Almeida Machado, Valter Viana de Andrade-Neto, Alessandra Marcia da Fonseca-Martins, Amy Goundry, João Vitor Marques Pereira da Silva, Daniel Claudio Oliveira Gomes, Ana Paula Cabral de Araujo Lima, Vítor Ennes-Vidal, Ana Carolina Rennó Sodero, Salvatore Giovanni De-Simone, Herbert L. de Matos Guedes

Publikováno v: Current Issues in Molecular Biology, Vol 44, Iss 5, Pp 2089-2106 (2022)

Subtilisin proteases, found in all organisms, are enzymes important in the post-translational steps of protein processing. In Leishmania major and L. donovani, this enzyme has been described as essential to their survival; however, few compounds that

Externí odkaz: https://doaj.org/article/14a0437ab2f54905977ef75da53f1211

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Akademický článek

Tissue Specific Dual RNA-Seq Defines Host–Parasite Interplay in Murine Visceral Leishmaniasis Caused by Leishmania donovani and Leishmania infantum

Autor: Sarah Forrester, Amy Goundry, Bruna Torres Dias, Thyago Leal-Calvo, Milton Ozório Moraes, Paul M. Kaye, Jeremy C. Mottram, Ana Paula C. A. Lima

Publikováno v: Microbiology Spectrum, Vol 10, Iss 2 (2022)

ABSTRACT Visceral leishmaniasis is associated with hepato-splenomegaly and altered immune and hematological parameters in both preclinical animal models and humans. We studied mouse experimental visceral leishmaniasis caused by Leishmania infantum an

Externí odkaz: https://doaj.org/article/f8e33324c0cf47c68037d65da0732fd3

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Akademický článek

Toll-Like Receptor- and Protein Kinase R-Induced Type I Interferon Sustains Infection of Leishmania donovani in Macrophages

Autor: Bruna T. Dias, Amy Goundry, Aislan C. Vivarini, Tatiana F. R. Costa, Jeremy C. Mottram, Ulisses G. Lopes, Ana Paula C. A. Lima

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

Leishmania donovani is a protozoan parasite that causes visceral leishmaniasis, provoking liver and spleen tissue destruction that is lethal unless treated. The parasite replicates in macrophages and modulates host microbicidal responses. We have pre

Externí odkaz: https://doaj.org/article/b3aa75d17036439192dc916b9bd57d19

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Akademický článek

Role of the inhibitor of serine peptidase 2 (ISP2) of Trypanosoma brucei rhodesiense in parasite virulence and modulation of the inflammatory responses of the host.

Autor: David Jessula Levy, Amy Goundry, Raquel S S Laires, Tatiana F R Costa, Carlos Mendes Novo, Dennis J Grab, Jeremy C Mottram, Ana Paula C A Lima

Publikováno v: PLoS Neglected Tropical Diseases, Vol 15, Iss 6, p e0009526 (2021)

Trypanosoma brucei rhodesiense is one of the causative agents of Human African Trypanosomiasis (HAT), known as sleeping sickness. The parasite invades the central nervous system and causes severe encephalitis that is fatal if left untreated. We have

Externí odkaz: https://doaj.org/article/c08c22115c764719b4f414f0aed7bf4e

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Akademický článek

Attempts to Image the Early Inflammatory Response during Infection with the Lymphatic Filarial Nematode Brugia pahangi in a Mouse Model.

Autor: Elmarie Myburgh, Ryan Ritchie, Amy Goundry, Kerry O'Neill, Francesco Marchesi, Eileen Devaney

Publikováno v: PLoS ONE, Vol 11, Iss 12, p e0168602 (2016)

Helminth parasites remain a major constraint upon human health and well-being in many parts of the world. Treatment of these infections relies upon a very small number of therapeutics, most of which were originally developed for use in animal health.

Externí odkaz: https://doaj.org/article/7ce0a09dd43841ff8a31f119320871d1

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Trypanosoma brucei rhodesiense Inhibitor of Cysteine Peptidase (ICP) Is Required for Virulence in Mice and to Attenuate the Inflammatory Response

Autor: Tatiana F. R. Costa, Amy Goundry, Alexandre Morrot, Dennis J. Grab, Jeremy C. Mottram, Ana Paula C. A. Lima

Publikováno v: International Journal of Molecular Sciences; Volume 24; Issue 1; Pages: 656

The protozoan Trypanosoma brucei rhodesiense causes Human African Trypanosomiasis, also known as sleeping sickness, and penetrates the central nervous system, leading to meningoencephalitis. The Cathepsin L-like cysteine peptidase of T. b. rhodesiens

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4f114ab51cfb6bc16f32325a7b2b1f6
https://doi.org/10.3390/ijms24010656

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Role of the inhibitor of serine peptidase 2 (ISP2) of Trypanosoma brucei rhodesiense in parasite virulence and modulation of the inflammatory responses of the host

Autor: Raquel S. S. Laires, Amy Goundry, Dennis J Grab, Ana Paula C. A. Lima, Tatiana F. R. Costa, Jeremy C. Mottram, David Jessula Levy, Carlos Novo

Publikováno v: PLoS Neglected Tropical Diseases, Vol 15, Iss 6, p e0009526 (2021)
PLoS Neglected Tropical Diseases

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fc942a2d961fe9fa1d79e67930bcd79
https://eprints.gla.ac.uk/245376/1/245376.pdf

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Inhibitor of serine peptidase 2 enhances Leishmania major survival in the skin through control of monocytes and monocyte-derived cells

Autor: Amy, Goundry, Audrey, Romano, Ana Paula C A, Lima, Jeremy C, Mottram, Elmarie, Myburgh

Publikováno v: The FASEB Journal

Leishmania major is the causative agent of the neglected tropical disease, cutaneous leishmaniasis. In the mouse, protective immunity to Leishmania is associated with inflammatory responses. Here, we assess the dynamics of the inflammatory responses

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cc5d9ea889a2ad9eedd6044a7fb02244
https://pubmed.ncbi.nlm.nih.gov/29097502

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Attempts to Image the Early Inflammatory Response during Infection with the Lymphatic Filarial Nematode Brugia pahangi in a Mouse Model

Autor: Ryan Ritchie, Amy Goundry, Francesco Marchesi, Kerry O'Neill, Elmarie Myburgh, Eileen Devaney

Publikováno v: PLoS ONE, Vol 11, Iss 12, p e0168602 (2016)
PLoS ONE

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bc986cd5b024b9a760fff42cf705bae
https://doaj.org/article/7ce0a09dd43841ff8a31f119320871d1

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