Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Amy, DiCamillo"'
Publikováno v:
Behavioural brain research. 438
Diabetes mellitus (DM), peripheral insulin resistance (IR) and obesity are clear risk factors for Alzheimer's disease. Several anti-diabetic drugs and insulin have been tested in rodents and humans with MCI or AD, yielding promising but inconclusive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4258c6d7998c582bcca4cdc9aa64a113
https://pubmed.ncbi.nlm.nih.gov/36404570
https://pubmed.ncbi.nlm.nih.gov/36404570
Autor:
H. Steven White, Melissa Barker-Haliski, Michael S. Saporito, Richard Hinchliffe, Amy DiCamillo, John A. Gruner
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 368(3)
Ganaxolone (GNX) is the 3β-methylated synthetic analog of the naturally occurring neurosteroid, allopregnanolone (ALLO). GNX is effective in a broad range of epilepsy and behavioral animal models and is currently in clinical trials designed to asses
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b409518a5e1904d36455c2b1c7c016c
https://pubmed.ncbi.nlm.nih.gov/30552296
https://pubmed.ncbi.nlm.nih.gov/30552296
Publikováno v:
Current Protocols in Pharmacology
Detailed in this unit is a mouse model of overactive bladder and urinary incontinence based on diuretic stress-induced urination. The procedure involves the use of a unique, highly sensitive, and automated urine capturing method to measure urinary la
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31715307588d8d68e5a2cc9e80be118f
https://pubmed.ncbi.nlm.nih.gov/27636110
https://pubmed.ncbi.nlm.nih.gov/27636110
Autor:
Thomas J. Connors, Jie Qian, Zeck Huang, Joanne R. Mathiasen, Edward R. Bacon, Thelma S. Angeles, Mark J. Huffman, Emir Duzic, Joseph M. Salvino, Beth Ann McKenna, Hervé Schaffhauser, Robert J. McHugh, Lily D. Lu, George C. Morton, Beverly P. Holskin, Karla Kopec, Amy DiCamillo, Gerard C. Rosse, Chrysanthe Spais, Rabindranath Tripathy, Lisa D. Aimone
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:1421-1426
Serotoninergic neurotransmission has been implicated in modulation of learning and memory. It has been demonstrated that 5-hydroxytryptamine(6) (5-HT(6)) receptor antagonists show beneficial effect on cognition in several animal models. Based on a ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::33e912dffb6b9ff1c34528c45a1f47ab
https://doi.org/10.1016/j.bmcl.2011.12.026
https://doi.org/10.1016/j.bmcl.2011.12.026
Autor:
Beverly P. Holskin, Karla Kopec, Joanne R. Mathiasen, Amy DiCamillo, Babu G. Sundar, Thomas J. Connors, Emir Duzic, Edward R. Bacon, Gerard C. Rosse, Chrysanthe Spais, Thomas R. Bailey, Beth Ann McKenna, Rebecca A. Brown, Jie Qian, Derek Dunn, Mark J. Huffman, Joseph M. Salvino, Huang Zeqi, Lisa D. Aimone, Hervé Schaffhauser, Deborah Galinis, Thelma S. Angeles, Lily D. Lu, George C. Morton
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:120-123
7-Arylsulfonyl substituted benzofuropiperidine was discovered as a novel scaffold for 5HT(6) receptor antagonists. Optimization by substitution at C-1 position led to identification of selective, orally bioavailable, brain penetrant antagonists with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a63c099e60dd280977edea44193b5a96
https://doi.org/10.1016/j.bmcl.2011.11.050
https://doi.org/10.1016/j.bmcl.2011.11.050
Autor:
Rabindranath, Tripathy, Robert J, McHugh, Edward R, Bacon, Joseph M, Salvino, George C, Morton, Lisa D, Aimone, Zeck, Huang, Joanne R, Mathiasen, Amy, DiCamillo, Mark J, Huffman, Beth A, McKenna, Karla, Kopec, Lily D, Lu, Jie, Qian, Thelma S, Angeles, Thomas, Connors, Chrysanthe, Spais, Beverly, Holskin, Emir, Duzic, Hervé, Schaffhauser, Gerard C, Rossé
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(3)
Serotoninergic neurotransmission has been implicated in modulation of learning and memory. It has been demonstrated that 5-hydroxytryptamine(6) (5-HT(6)) receptor antagonists show beneficial effect on cognition in several animal models. Based on a ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bbd67be491fa50904fc04fc20c374a04
https://pubmed.ncbi.nlm.nih.gov/22226656
https://pubmed.ncbi.nlm.nih.gov/22226656
Autor:
Babu G, Sundar, Thomas R, Bailey, Derek D, Dunn, Edward R, Bacon, Joseph M, Salvino, George C, Morton, Lisa D, Aimone, Huang, Zeqi, Joanne R, Mathiasen, Amy, Dicamillo, Mark J, Huffman, Beth A, McKenna, Karla, Kopec, Lily D, Lu, Rebecca, Brown, Jie, Qian, Thelma, Angeles, Thomas, Connors, Chrysanthe, Spais, Beverly, Holskin, Deborah, Galinis, Emir, Duzic, Herve, Schaffhauser, Gerard C, Rosse
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(1)
7-Arylsulfonyl substituted benzofuropiperidine was discovered as a novel scaffold for 5HT(6) receptor antagonists. Optimization by substitution at C-1 position led to identification of selective, orally bioavailable, brain penetrant antagonists with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9b0ab8369735ed85da9712148db21027
https://pubmed.ncbi.nlm.nih.gov/22153937
https://pubmed.ncbi.nlm.nih.gov/22153937
Autor:
Amy DiCamillo, Joanne R. Mathiasen
Publikováno v:
Current Protocols in Neuroscience
Neuropsychiatric disorders encompass a broad patient population in a variety of disease states across all age groups and are often accompanied by deficits in short-term/working memory. However, most preclinical models that allow for an assessment of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29dbbf7ad0881f82685e671c12b47997
https://pubmed.ncbi.nlm.nih.gov/20938925
https://pubmed.ncbi.nlm.nih.gov/20938925
Autor:
Joanne R. Mathiasen, Amy DiCamillo
Publikováno v:
Current Protocols in Pharmacology
The rat novel object recognition (NOR) assay is a relatively high-throughput, robust, and sensitive procedure for evaluating compounds for cognition-enhancing activity. For the test, rats are given the opportunity to explore two identical objects for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0789a88fc57670511993b0dbba8c793a
https://doi.org/10.1002/0471141755.ph0559s49
https://doi.org/10.1002/0471141755.ph0559s49
Autor:
Beth Ann McKenna, Mark J. Huffman, Hervé Schaffhauser, Lily D. Lu, Jie Qian, Amy DiCamillo, Joanne R. Mathiasen, Michael J. Marino
Publikováno v:
Biochemical pharmacology. 78(8)
Dimebolin (Dimebon), is a non-selective antihistamine approved in Russia for the treatment of allergy. Recently, this drug has been shown to be neuroprotective in cellular models of Alzheimer's disease and Huntington's disease, and to preserve cognit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01ed43802ef7e5aca7aa2dd2b24fa90a
https://pubmed.ncbi.nlm.nih.gov/19549510
https://pubmed.ncbi.nlm.nih.gov/19549510