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pro vyhledávání: '"Amy, Dave"'
Viral Infections and Autoimmune Disease: Roles of LCMV in Delineating Mechanisms of Immune Tolerance
Autor:
Georgia Fousteri, Amy Dave Jhatakia
Publikováno v:
Viruses, Vol 11, Iss 10, p 885 (2019)
Viral infections are a natural part of our existence. They can affect us in many ways that are the result of the interaction between the viral pathogen and our immune system. Most times, the resulting immune response is beneficial for the host. The p
Externí odkaz:
https://doaj.org/article/e828a9a46072414d91129c471079c981
Autor:
Ghanashyam Sarikonda, Georgia Fousteri, Sowbarnika Sachithanantham, Jacqueline F Miller, Amy Dave, Therese Juntti, Ken T Coppieters, Matthias von Herrath
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e112242 (2014)
The infusion of ex vivo-expanded autologous T regulatory (Treg) cells is potentially an effective immunotherapeutic strategy against graft-versus-host disease (GvHD) and several autoimmune diseases, such as type 1 diabetes (T1D). However, in vitro di
Externí odkaz:
https://doaj.org/article/e87af32233064d9d86e31b3da2999a3f
Autor:
Georgia Fousteri, Amy Dave, Amy Juedes, Therese Juntti, Bret Morin, Lisa Togher, Donna L Farber, Matthias von Herrath
Publikováno v:
PLoS ONE, Vol 6, Iss 1, p e14502 (2011)
Memory CD8 T cells form an essential part of protective immunity against viral infections. Antigenic load, costimulation, CD4-help, cytokines and chemokines fluctuate during the course of an antiviral immune response thus affecting CD8 T cell activat
Externí odkaz:
https://doaj.org/article/894a5318d7e84d1485638aeec7506887
Akademický článek
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Autor:
Sowbarnika Sachithanantham, Carmen Baca Jones, Teresa Rodriguez-Calvo, Jacqueline Miller, Matthias von Herrath, Philippe P. Pagni, Amy Dave, Georgia Fousteri
Publikováno v:
Clinical Immunology. 153:298-307
While previous reports have demonstrated the efficacy of regulatory T cell therapy in the prevention of diabetes, systemic immunocompromise and Treg instability remain key safety concerns. Here we examined the influence of induced Treg (iTreg) cell t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c2f15334f6ffc8d6649424a80881d8f
https://doi.org/10.1016/j.clim.2014.05.006
https://doi.org/10.1016/j.clim.2014.05.006
Autor:
Georgia Fousteri, Maki Nakayama, Michael Croft, Yang Cheng, Matthias von Herrath, Florence Lambolez, Hilde Cheroutre, Amy Dave, George S. Eisenbarth, Philippe P. Pagni, Jean Jasinski, Therese Juntti, Ghanashyam Sarikonda
Publikováno v:
Diabetes. 61:1169-1179
In diabetic patients and susceptible mice, insulin is a targeted autoantigen. Insulin B chain 9-23 (B:9-23) autoreactive CD4 T cells are key for initiating autoimmune diabetes in NOD mice; however, little is known regarding their origin and function.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4b0c86d7f2f25c1f5cd92a15fa5103bb
https://doi.org/10.2337/db11-0671
https://doi.org/10.2337/db11-0671
Publikováno v:
Journal of Autoimmunity. 36:210-220
Myocarditis poses a severe health problem, can lead to dilated cardiomyopathy (DCM) and death, and is thought to be triggered by infections. Enteroviruses such as Coxsackie virus B 3 (CVB3) have been implicated as a culprit, since they can cause acut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52b382a0e468aa0111390b09b02824bf
https://doi.org/10.1016/j.jaut.2011.01.006
https://doi.org/10.1016/j.jaut.2011.01.006
Autor:
Michael Croft, Chan C. Whiting, Jason R. Chan, Amy Dave, Damien Bresson, Yanan Zheng, Matthias von Herrath, Georgia Fousteri
Publikováno v:
Diabetes
OBJECTIVE Development of antigen-specific strategies to treat or prevent type 1 diabetes has been slow and difficult because of the lack of experimental tools and defined biomarkers that account for the underlying therapeutic mechanisms. RESEARCH DES
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c2200858e2dd71626d38e518a0065db
https://doi.org/10.2337/db10-0561
https://doi.org/10.2337/db10-0561
Publikováno v:
Diabetologia
Aims/hypothesis Subcutaneous immunisation with the 9–23 amino acid region of the insulin B chain (B:9-23) in incomplete Freund’s adjuvant (IFA) can protect the majority of 4- to 6-week-old prediabetic NOD mice and is currently in clinical trials.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b04b8382413ce9e99b557de621606d56
https://doi.org/10.1007/s00125-010-1777-x
https://doi.org/10.1007/s00125-010-1777-x
Publikováno v:
Journal of Autoimmunity. 32:70-77
Recent studies suggest a beneficial role for blocking CD103 signaling in preventing islet allograft rejection and thus Type 1 diabetes (T1D) in non-obese diabetic (NOD) mice. However, antibody blockade approaches generally raise anti-microbial safety
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb5452c9b3edcdf6930f041bc3dae58b
https://doi.org/10.1016/j.jaut.2008.12.001
https://doi.org/10.1016/j.jaut.2008.12.001