Zobrazeno 1 - 10 of 47 pro vyhledávání: '"Amuvatinib"'
1
Akademický článek
βIII‐tubulin suppression enhances the activity of Amuvatinib to inhibit cell proliferation in c‐Met positive non‐small cell lung cancer cells
Autor: Simon Brayford, Alastair Duly, Wee Siang Teo, Tanya Dwarte, Estrella Gonzales‐Aloy, Zerong Ma, Laura McVeigh, Timothy W. Failes, Greg M. Arndt, Joshua A. McCarroll, Maria Kavallaris
Publikováno v: Cancer Medicine, Vol 12, Iss 4, Pp 4455-4471 (2023)
Abstract Non‐Small Cell Lung Carcinoma (NSCLC) remains a leading cause of cancer death. Resistance to therapy is a significant problem, highlighting the need to find new ways of sensitising tumour cells to therapeutic agents. βIII‐tubulin is ass
Externí odkaz: https://doaj.org/article/ca6480afb088470ca3e0c2a36817e4bf
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2
Akademický článek
Amuvatinib Blocks SARS-CoV-2 Infection at the Entry Step of the Viral Life Cycle
Autor: Trang T. X. Huynh, Thuy X. Pham, Gun-Hee Lee, Jae-Bong Lee, Sung-Geun Lee, Dongseob Tark, Yun-Sook Lim, Soon B. Hwang
Publikováno v: Microbiology Spectrum, Vol 11, Iss 3 (2023)
ABSTRACT Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease 2019 (COVID-19). SARS-CoV-2 propagation is mediated by the protein interaction between viral proteins and host cells. Tyrosine kinase
Externí odkaz: https://doaj.org/article/5a48daac5d894da284da852e0950ef88
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3
Akademický článek
The Amuvatinib Derivative, N-(2H-1,3-Benzodioxol-5-yl)-4-{thieno[3,2-d]pyrimidin-4-yl}piperazine-1-carboxamide, Inhibits Mitochondria and Kills Tumor Cells under Glucose Starvation
Autor: Ran Marciano, Hila Ben David, Barak Akabayov, Barak Rotblat
Publikováno v: International Journal of Molecular Sciences, Vol 21, Iss 3, p 1041 (2020)
Glucose levels inside solid tumors are low as compared with normal surrounding tissue, forcing tumor cells to reprogram their metabolism to adapt to such low glucose conditions. Unlike normal tissue, tumor cells experience glucose starvation, making
Externí odkaz: https://doaj.org/article/54d4b71fcd1544409bfbf87f43e864a0
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4
Akademický článek
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5
Akademický článek
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6
The Amuvatinib Derivative, N-(2H-1,3-Benzodioxol-5-yl)-4-{thieno[3,2-d]pyrimidin-4-yl}piperazine-1-carboxamide, Inhibits Mitochondria and Kills Tumor Cells under Glucose Starvation
Autor: Barak Akabayov, Barak Rotblat, Hila Ben David, Ran Marciano
Publikováno v: International Journal of Molecular Sciences, Vol 21, Iss 3, p 1041 (2020)
International Journal of Molecular Sciences
Volume 21
Issue 3
Glucose levels inside solid tumors are low as compared with normal surrounding tissue, forcing tumor cells to reprogram their metabolism to adapt to such low glucose conditions. Unlike normal tissue, tumor cells experience glucose starvation, making
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e727c4d328afab9f3cc02ae8fd672318
https://www.mdpi.com/1422-0067/21/3/1041
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7
A phase 2, open-label, multi-center study of amuvatinib in combination with platinum etoposide chemotherapy in platinum-refractory small cell lung cancer patients
Autor: Maciej Krzakowski, D.R. Camidge, Jitendra Ghandi, Saiama N. Waqar, Robert J. Cardnell, Junya Fujimoto, Pietro Taverna, Taofeek K. Owonikoko, Goetz Kloecker, Lauren Averett Byers, Leora Horn, Mohammad Azab
Publikováno v: Oncotarget
// Lauren Averett Byers 1 , Leora Horn 2 , Jitendra Ghandi 3 , Goetz Kloecker 4 , Taofeek Owonikoko 5 , Saiama Naheed Waqar 6 , Maciej Krzakowski 7 , Robert J. Cardnell 1 , Junya Fujimoto 1 , Pietro Taverna 8 , Mohammad Azab 8 and David Ross Camidge
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::761a76ff9851abb96a5e5676cc33467d
https://doi.org/10.18632/oncotarget.19888
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8
Design, synthesis, biological evaluation and molecular modeling study of new thieno[2,3-d]pyrimidines with anti-proliferative activity on pancreatic cancer cell lines
Autor: Khaled A.M. Abouzid, Mohamed M. Said, Mohamed S. H. Salem, Mohamed Saleh Elgawish, Yasmine M. Abdel Aziz
Publikováno v: Bioorganic Chemistry. 94:103472
Pancreatic cancer is one of the most challenging diseases with seven months only as median survival time due to its poor prognosis. Several enzymes are blamed for the progress of pancreatic cancer especially, platelet-derived growth factor receptors
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a377f7cffde7d2086516765dc8339faa
https://doi.org/10.1016/j.bioorg.2019.103472
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9
Akademický článek
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10
Phase 1B study of amuvatinib in combination with five standard cancer therapies in adults with advanced solid tumors
Autor: Aram Oganesian, Monica M. Mita, Amarpal Sahai, Sanjeev Redkar, Michael S. Gordon, Lee S. Rosen, Pietro Taverna, Nirmal Kapoor, Anthony W. Tolcher, Mohammad Azab, Robert G. Bristow, Gavin Choy
Publikováno v: Cancer Chemotherapy and Pharmacology. 74:195-204
Amuvatinib is an oral multi-kinase inhibitor that suppresses RAD51, inhibits mutant c-KIT and platelet-derived growth factor receptor alpha, and has synergistic activity with DNA-damaging agents and topoisomerase inhibitors such as etoposide, doxorub
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d5e027fc3a400f01be8a93da67d72fa
https://doi.org/10.1007/s00280-014-2481-1
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