Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Amutha, Boominathan"'
Autor:
David V. Begelman, Bhavna Dixit, Carly Truong, Christina D. King, Mark A. Watson, Birgit Schilling, Martin D. Brand, Amutha Boominathan
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 4, Pp 101372- (2024)
Replicative errors, inefficient repair, and proximity to sites of reactive oxygen species production make mitochondrial DNA (mtDNA) susceptible to damage with time. We explore in vivo allotopic expression (re-engineering mitochondrial genes and expre
Externí odkaz:
https://doaj.org/article/df6f8d7c84984156a9146f7f86548334
Publikováno v:
MethodsX, Vol 8, Iss , Pp 101197- (2021)
We describe here a simple method to enrich mitochondrial fractions from mammalian cells for downstream analyses in the lab. Mitochondria purification involves cell lysis followed by separation of the organelles from the rest of the cellular component
Externí odkaz:
https://doaj.org/article/38c7b777d5e34bf9beaebceacbf8b11c
Autor:
Caitlin J. Lewis, Bhavna Dixit, Elizabeth Batiuk, Carter J. Hall, Matthew S. O'Connor, Amutha Boominathan
Publikováno v:
Redox Biology, Vol 30, Iss , Pp - (2020)
Mutations in mitochondrial DNA can be inherited or occur de novo leading to several debilitating myopathies with no curative option and few or no effective treatments. Allotopic expression of recoded mitochondrial genes from the nucleus has potential
Externí odkaz:
https://doaj.org/article/1395d5af9a194fd0b46dc6897419b1dc
Autor:
Sanjana Saravanan, Caitlin J. Lewis, Bhavna Dixit, Matthew S. O’Connor, Alexandra Stolzing, Amutha Boominathan
Publikováno v:
Biomedicines, Vol 10, Iss 2, p 490 (2022)
Mitochondria are intracellular organelles that utilize nutrients to generate energy in the form of ATP by oxidative phosphorylation. Mitochondrial DNA (mtDNA) in humans is a 16,569 base pair double-stranded circular DNA that encodes for 13 vital prot
Externí odkaz:
https://doaj.org/article/409bea393f7144ba82b88627923cd094
Publikováno v:
In Methods in Enzymology 2009 456:247-266
Autor:
Amutha, Boominathan, Gordon, Donna M., Gu, Yajuan, Lyver, Elise R., Dancis, Andrew, Pain, Debkumar
Publikováno v:
In Journal of Biological Chemistry 18 January 2008 283(3):1362-1371
Publikováno v:
In Journal of Biological Chemistry 13 May 2005 280(19):18604-18609
Autor:
Amutha Boominathan, Carter J. Hall, Elizabeth Batiuk, Caitlin J. Lewis, Bhavna Dixit, Matthew S. O'Connor
Publikováno v:
Redox Biology
Redox Biology, Vol 30, Iss, Pp-(2020)
Redox Biology, Vol 30, Iss, Pp-(2020)
Mutations in mitochondrial DNA can be inherited or occur de novo leading to several debilitating myopathies with no curative option and few or no effective treatments. Allotopic expression of recoded mitochondrial genes from the nucleus has potential
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1854fe5b580e451f444bb837e232253d
https://doi.org/10.1016/j.redox.2020.101429
https://doi.org/10.1016/j.redox.2020.101429
Publikováno v:
In BBA - General Subjects 1999 1427(1):121-132
Autor:
Disha Dayal, Prabhat C. Goswami, Sean M. Martin, Yueming Zhu, Debkumar Pain, Kjerstin M. Owens, Douglas R. Spitz, Charles L. Limoli, Frederick E. Domann, Nukhet Aykin-Burns, Amutha Boominathan
Publikováno v:
Radiation Research. 172:737-745
Ionizing radiation induces chronic metabolic oxidative stress and a mutator phenotype in hamster fibroblasts that is mediated by H(2)O(2), but the intracellular source of H(2)O(2) is not well defined. To determine the role of mitochondria in the radi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b51f555c301a7358e6b9eef61ceaf16
https://doi.org/10.1667/rr1617.1
https://doi.org/10.1667/rr1617.1