Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Amudha Deivasigamani"'
Autor:
Cunjie Chang, Muthukumar Rajasekaran, Yiting Qiao, Heng Dong, Yu Wang, Hongping Xia, Amudha Deivasigamani, Minjie Wu, Karthik Sekar, Hengjun Gao, Mengqing Sun, Yuqin Niu, Qian Li, Lin Tao, Zhen Yan, Menglan Wang, Shasha Chen, Shujuan Zhao, Dajing Chen, Lina Li, Fan Yang, Haojin Gao, Baodong Chen, Ling Su, Liang Xu, Ye Chen, Veerabrahma Pratap Seshachalam, Gongxing Chen, Jayantha Gunaratne, Wanjin Hong, Junping Shi, Gongying Chen, David S. Grierson, Benoit Chabot, Tian Xie, Kam Man Hui, Jianxiang Chen
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Alternative splicing is dysregulated in hepatocellular carcinoma. Here, the authors investigate the role of the splice variant of Splicing Regulatory Glutamic Acid and Lysine Rich Protein 1 (SREK1) and its upstream regulator, Serine/arginine-rich spl
Externí odkaz:
https://doaj.org/article/899e96a6dffd4ad49c98b29c783e660e
Autor:
Ser Yue Loo, Nicholas L. Syn, Angele Pei-Fern Koh, Janet Cheng-Fei Teng, Amudha Deivasigamani, Tuan Zea Tan, Aye Aye Thike, Shireen Vali, Shweta Kapoor, Xiaoyuan Wang, Jiong Wei Wang, Puay Hoon Tan, George W. Yip, Gautam Sethi, Ruby Yun-Ju Huang, Kam Man Hui, Lingzhi Wang, Boon Cher Goh, Alan Prem Kumar
Publikováno v:
Cell Death Discovery, Vol 7, Iss 1, Pp 1-15 (2021)
Abstract Clinical trials repurposing peroxisome proliferator-activated receptor-gamma (PPARγ) agonists as anticancer agents have exhibited lackluster efficacy across a variety of tumor types. Here, we report that increased PPARG expression is associ
Externí odkaz:
https://doaj.org/article/82fb2ea92fce4d45b46ee3f019c45a37
Autor:
Jong Hyun Lee, Chakrabhavi Dhananjaya Mohan, Amudha Deivasigamani, Young Yun Jung, Shobith Rangappa, Salundi Basappa, Arunachalam Chinnathambi, Tahani Awad Alahmadi, Sulaiman Ali Alharbi, Manoj Garg, Zhi-Xiu Lin, Kanchugarakoppal S. Rangappa, Gautam Sethi, Kam Man Hui, Kwang Seok Ahn
Publikováno v:
Journal of Advanced Research, Vol 26, Iss , Pp 83-94 (2020)
Introduction: Epithelial-mesenchymal transition (EMT) is a process of transdifferentiation where epithelial cells attain mesenchymal phenotype to gain invasive properties and thus, can contribute to metastasis of tumor cells. Objectives: The antimeta
Externí odkaz:
https://doaj.org/article/b49452f32a3546068e13458d992b5aa4
Autor:
Chakrabhavi Dhananjaya Mohan, Min Hee Yang, Shobith Rangappa, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Tahani Awad Alahmadi, Amudha Deivasigamani, Kam Man Hui, Gautam Sethi, Kanchugarakoppal S. Rangappa, Kwang Seok Ahn
Publikováno v:
Biology, Vol 11, Iss 1, p 29 (2021)
Hepatocellular carcinoma (HCC) is one of the leading cancers that contribute to a large number of deaths throughout the globe. The signal transducer and activator of transcription 3 (STAT3) is a tumorigenic protein that is overactivated in several hu
Externí odkaz:
https://doaj.org/article/647e2bc3c43e4c4d83b4d41814cdaec9
Autor:
Chakrabhavi Dhananjaya Mohan, Hanumantharayappa Bharathkumar, Dukanya, Shobith Rangappa, Muthu K. Shanmugam, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Tahani Awad Alahmadi, Atanu Bhattacharjee, Peter E. Lobie, Amudha Deivasigamani, Kam Man Hui, Gautam Sethi, Basappa, Kanchugarakoppal S. Rangappa, Alan Prem Kumar
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
Hepatocellular carcinoma (HCC) is a fatal disease and ranked fifth in cancer related mortality. Persistent activation of NF-κB is responsible for the oncogenesis, metastasis, tumor evasion, anti-apoptosis, angiogenesis and proliferation in HCC. Ther
Externí odkaz:
https://doaj.org/article/d5819da4373f47f6b9facf42d97c164c
Autor:
Qing-Zhe Dong, Shenling Li, Fengyun Hao, Amudha Deivasigamani, Nian-Kai Zhang, Brian K. P. Goh, Kam M. Hui, Yu Wang, Karthik Sekar, Yan Jiang, Clara Kai Ting Koh, London L.P.J. Ooi, Senbiao Luo, Xiao-Dan Jiang
Publikováno v:
Cancer Research and Treatment : Official Journal of Korean Cancer Association
Purpose NUF2 has been implicated in multiple cancers recently, suggesting NUF2 may play a role in the common tumorigenesis process. In this study, we aim to perform comprehensive meta-analysis of NUF2 expression in the cancer types included in the Ca
Autor:
Min Hee Yang, Chakrabhavi Dhananjaya Mohan, Amudha Deivasigamani, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Kanchugarakoppal S. Rangappa, Sang Hoon Jung, Hyejin Ko, Kam Man Hui, Gautam Sethi, Kwang Seok Ahn
Publikováno v:
Cancers; Volume 14; Issue 20; Pages: 4978
EMT is a critical cellular phenomenon that promotes tumor invasion and metastasis. Procaine is a local anesthetic agent used in oral surgeries and as an inhibitor of DNA methylation in some types of cancers. In this study, we have investigated whethe
Autor:
Arunachalam Chinnathambi, Young Yun Jung, Amudha Deivasigamani, Kanchugarakoppal S. Rangappa, Salundi Basappa, Kam M. Hui, Shobith Rangappa, Manoj Garg, Zhi-Xiu Lin, Sulaiman Ali Alharbi, Chakrabhavi Dhananjaya Mohan, Kwang Seok Ahn, Gautam Sethi, Jong Hyun Lee, Tahani Awad Alahmadi
Publikováno v:
Journal of Advanced Research
Journal of Advanced Research, Vol 26, Iss, Pp 83-94 (2020)
Journal of Advanced Research, Vol 26, Iss, Pp 83-94 (2020)
Graphical abstract
Highlights • Brusatol affects migration and invasion ability of HCC cells. • Brusatol affects EMT process through modulation of STAT3 activation pathway. • Brusatol mitigates tumorigenesis and metastasis in HCC preclinic
Highlights • Brusatol affects migration and invasion ability of HCC cells. • Brusatol affects EMT process through modulation of STAT3 activation pathway. • Brusatol mitigates tumorigenesis and metastasis in HCC preclinic
Autor:
Jingwen Zhang, Young Yun Jung, Chakrabhavi Dhananjaya Mohan, Amudha Deivasigamani, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Kanchugarakoppal S. Rangappa, Kam Man Hui, Gautam Sethi, Kwang Seok Ahn
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1869:119344
Prostate cancer is the second most frequent type of cancer that affects men. Docetaxel (DTX) administration is the front-line therapy for patients with advanced prostate cancer and unfortunately, half of these patients develop resistance to DTX which
Autor:
Han-Yue OuYang, Yu Wang, Brian K. P. Goh, Amudha Deivasigamani, Veerabrahma Pratap Seshachalam, London L.P.J. Ooi, Karthik Sekar, Yohana Ayupriyanti Handoko, Kam M. Hui, Ming Shi, Chan Xie, Peng Yang Tan, Bin Gao
Publikováno v:
The FASEB Journal
Hepatocellular carcinoma (HCC) is a common and deadly cancer with limited treatment options. Through genome-wide growth depletion screens using clustered regularly interspaced short palindromic repeats and expression profiling of primary HCC tumors,