Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Amruta Ronghe"'
Autor:
Gaurav Sharma, Rani Ojha, Estela Noguera-Ortega, Vito W. Rebecca, John Attanasio, Shujing Liu, Shengfu Piao, Jennifer J. Lee, Michael C. Nicastri, Sandra L. Harper, Amruta Ronghe, Vaibhav Jain, Jeffrey D. Winkler, David W. Speicher, Jerome Mastio, Phyllis A. Gimotty, Xiaowei Xu, E. John Wherry, Dmitry I. Gabrilovich, Ravi K. Amaravadi
Publikováno v:
JCI Insight, Vol 7, Iss 20 (2022)
Externí odkaz:
https://doaj.org/article/643236f5ac4b4d019428d52c84e9657d
Autor:
Gaurav Sharma, Rani Ojha, Estela Noguera-Ortega, Vito W. Rebecca, John Attanasio, Shujing Liu, Shengfu Piao, Jennifer J. Lee, Michael C. Nicastri, Sandra L. Harper, Amruta Ronghe, Vaibhav Jain, Jeffrey D. Winkler, David W. Speicher, Jerome Mastio, Phyllis A. Gimotty, Xiaowei Xu, E. John Wherry, Dmitry I. Gabrilovich, Ravi K. Amaravadi
Publikováno v:
JCI Insight, Vol 5, Iss 17 (2020)
New strategies are needed to enhance the efficacy of anti–programmed cell death protein antibody (anti–PD-1 Ab) in cancer. Here, we report that inhibiting palmitoyl-protein thioesterase 1 (PPT1), a target of chloroquine derivatives like hydroxych
Externí odkaz:
https://doaj.org/article/1eb69c668c3c47a4ac86a114612e04f4
Autor:
Ravi K. Amaravadi, Jeffrey D. Winkler, David W. Speicher, Donita C. Brady, Roberto Zoncu, Meenhard Herlyn, Xiaowei Xu, Shujing Liu, Qin Liu, Ronen Marmorstein, Joshua Rabinowitz, Yiling Lu, Gordon B. Mills, Maureen E. Murphy, Julie S. Barber-Rotenberg, Zhi Wei, Samuel M. Levi, Rani Ojha, Sengottuvelan Murugan, Shengfu Piao, Gretchen M. Alicea, Gao Zhang, Cynthia I. Chude, Eric Witze, Chun-Yan Lim, Michel Nofal, Amruta Ronghe, Quentin McAfee, Colin Fennelly, Noel McLaughlin, Michael C. Nicastri, Vito W. Rebecca
Supplemental Chemical Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21a73a32df39358814d1916585f5a9c6
https://doi.org/10.1158/2159-8290.22532497.v1
https://doi.org/10.1158/2159-8290.22532497.v1
Autor:
Ravi K. Amaravadi, Jeffrey D. Winkler, David W. Speicher, Donita C. Brady, Roberto Zoncu, Meenhard Herlyn, Xiaowei Xu, Shujing Liu, Qin Liu, Ronen Marmorstein, Joshua Rabinowitz, Yiling Lu, Gordon B. Mills, Maureen E. Murphy, Julie S. Barber-Rotenberg, Zhi Wei, Samuel M. Levi, Rani Ojha, Sengottuvelan Murugan, Shengfu Piao, Gretchen M. Alicea, Gao Zhang, Cynthia I. Chude, Eric Witze, Chun-Yan Lim, Michel Nofal, Amruta Ronghe, Quentin McAfee, Colin Fennelly, Noel McLaughlin, Michael C. Nicastri, Vito W. Rebecca
Supplemental Figures and Table
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::757ddfcdc3c0b0e67e8ed83b0beed685
https://doi.org/10.1158/2159-8290.22532494
https://doi.org/10.1158/2159-8290.22532494
Autor:
Ravi K. Amaravadi, Jeffrey D. Winkler, David W. Speicher, Phyllis A. Gimotty, Ronen Marmorstein, Meenhard Herlyn, Xiaowei Xu, Lynn M. Schuchter, Jennifer J. Lee, Gretchen M. Alicea, Alessandra Martorella, Estela Noguera-Ortega, Shengfu Piao, Rani Ojha, Aaron R. Goldman, Gao Zhang, Noel P. McLaughlin, Quentin McAfee, Amruta Ronghe, Julie S. Barber-Rotenberg, Cynthia I. Chude, Colin Fennelly, Michael C. Nicastri, Vito W. Rebecca
Supplementary Figures S1-S4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34ca2788b50fc025f26327d0ffe171ee
https://doi.org/10.1158/2159-8290.22532723.v1
https://doi.org/10.1158/2159-8290.22532723.v1
Autor:
Ravi K. Amaravadi, Jeffrey D. Winkler, David W. Speicher, Phyllis A. Gimotty, Ronen Marmorstein, Meenhard Herlyn, Xiaowei Xu, Lynn M. Schuchter, Jennifer J. Lee, Gretchen M. Alicea, Alessandra Martorella, Estela Noguera-Ortega, Shengfu Piao, Rani Ojha, Aaron R. Goldman, Gao Zhang, Noel P. McLaughlin, Quentin McAfee, Amruta Ronghe, Julie S. Barber-Rotenberg, Cynthia I. Chude, Colin Fennelly, Michael C. Nicastri, Vito W. Rebecca
Chemical Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2010550c1625be6ad5a3851e6f932430
https://doi.org/10.1158/2159-8290.22532726.v1
https://doi.org/10.1158/2159-8290.22532726.v1
Autor:
Ravi K. Amaravadi, Jeffrey D. Winkler, David W. Speicher, Phyllis A. Gimotty, Ronen Marmorstein, Meenhard Herlyn, Xiaowei Xu, Lynn M. Schuchter, Jennifer J. Lee, Gretchen M. Alicea, Alessandra Martorella, Estela Noguera-Ortega, Shengfu Piao, Rani Ojha, Aaron R. Goldman, Gao Zhang, Noel P. McLaughlin, Quentin McAfee, Amruta Ronghe, Julie S. Barber-Rotenberg, Cynthia I. Chude, Colin Fennelly, Michael C. Nicastri, Vito W. Rebecca
Clinical trials repurposing lysosomotropic chloroquine (CQ) derivatives as autophagy inhibitors in cancer demonstrate encouraging results, but the underlying mechanism of action remains unknown. Here, we report a novel dimeric CQ (DC661) capable of d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31fbbe3005df3dacfe5a510f4e72acce
https://doi.org/10.1158/2159-8290.c.6546812
https://doi.org/10.1158/2159-8290.c.6546812
Autor:
Noel P. McLaughlin, Ronen Marmorstein, Julie S. Barber-Rotenberg, Aaron R. Goldman, Estela Noguera-Ortega, Gao Zhang, Michael C. Nicastri, Cynthia I. Chude, Quentin McAfee, David W. Speicher, Shengfu Piao, Vito W. Rebecca, Jeffrey D. Winkler, Rani Ojha, Lynn M. Schuchter, Alessandra Martorella, Phyllis A. Gimotty, Meenhard Herlyn, Xiaowei Xu, Gretchen M. Alicea, Jennifer J. Lee, Colin Fennelly, Amruta Ronghe, Ravi K. Amaravadi
Publikováno v:
Cancer Discovery. 9:220-229
Clinical trials repurposing lysosomotropic chloroquine (CQ) derivatives as autophagy inhibitors in cancer demonstrate encouraging results, but the underlying mechanism of action remains unknown. Here, we report a novel dimeric CQ (DC661) capable of d
Autor:
David W. Speicher, Jeffrey D. Winkler, Rani Ojha, Dmitry I. Gabrilovich, Michael C. Nicastri, Vaibhav Jain, Shengfu Piao, Shujing Liu, John Attanasio, Xiaowei Xu, Phyllis A. Gimotty, Ravi K. Amaravadi, Estela Noguera-Ortega, Jennifer J. Lee, Amruta Ronghe, Vito W. Rebecca, Jérôme Mastio, E. John Wherry, Gaurav Sharma, Sandra L. Harper
Publikováno v:
JCI Insight, Vol 5, Iss 17 (2020)
JCI Insight
JCI Insight
New strategies are needed to enhance the efficacy of anti–programmed cell death protein antibody (anti–PD-1 Ab) in cancer. Here, we report that inhibiting palmitoyl-protein thioesterase 1 (PPT1), a target of chloroquine derivatives like hydroxych
Autor:
Zhi Wei, Gao Zhang, Noel P. McLaughlin, Joshua D. Rabinowitz, Xiaowei Xu, David W. Speicher, Amruta Ronghe, Jeffrey D. Winkler, Gordon B. Mills, Michael C. Nicastri, Quentin McAfee, Ravi K. Amaravadi, Julie S. Barber-Rotenberg, Sengottuvelan Murugan, Qin Liu, Cynthia I. Chude, Donita C. Brady, Meenhard Herlyn, Michel Nofal, Roberto Zoncu, Yiling Lu, Rani Ojha, Gretchen M. Alicea, Vito W. Rebecca, Shengfu Piao, Ronen Marmorstein, Chun Yan Lim, Eric S. Witze, Maureen E. Murphy, Samuel M. Levi, Colin Fennelly, Shujing Liu
Publikováno v:
Cancer Discovery. 7:1266-1283
Lysosomes serve dual roles in cancer metabolism, executing catabolic programs (i.e., autophagy and macropinocytosis) while promoting mTORC1-dependent anabolism. Antimalarial compounds such as chloroquine or quinacrine have been used as lysosomal inhi