Výsledky vyhledávání - "Amruta R. Poreddy"

Roles of Free Radicals in Type 1 Phototherapeutic Agents: Aromatic Amines, Sulfenamides, and Sulfenates

Autor: Amolkumar S Karwa, Sungho V. Park, Amruta R. Poreddy, Raghavan Rajagopalan, Tien-Sung Lin, Yuefei Shen, Bethel Asmelash, John-Stephen Taylor

Publikováno v: The Journal of Physical Chemistry A. 117:5454-5462

Detailed analyses of the electron spin resonance (ESR) spectra, cell viability, and DNA degradation studies are presented for the photolyzed Type I phototherapeutic agents: aromatic amines, sulfenamides, and sulfenates. The ESR studies provided evide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fe1818577b09daf5f6a5de5d581e2c0
https://doi.org/10.1021/jp402745m

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Exogenous fluorescent tracer agents based on pegylated pyrazine dyes for real-time point-of-care measurement of glomerular filtration rate

Autor: Richard B. Dorshow, Bethel Asmelash, William L. Neumann, Jeng-Jong Shieh, Kimberly R. Gaston, John N. Freskos, Richard M. Fitch, Amruta R. Poreddy, Raghavan Rajagopalan, Karen P. Galen

Publikováno v: Bioorganic & Medicinal Chemistry. 20:2490-2497

Novel pyrazine carboxamides bearing hydrophilic poly(ethylene glycol) (PEG) moieties were designed, synthesized, and evaluated for use as fluorescent glomerular filtration rate (GFR) tracer agents. Among these, compounds 4d and 5c that contain about

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78e837a5676a2e95ab4e99b82cc80665
https://doi.org/10.1016/j.bmc.2012.03.015

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Type 1 Phototherapeutic Agents, Part I: Preparation and Cancer Cell Viability Studies of Novel Photolabile Sulfenamides

Autor: Amolkumar Karwa, Richard B. Dorshow, Tien-Sung Lin, Bethel Asmelash, Amruta R. Poreddy, Raghavan Rajagopalan

Publikováno v: ACS Medicinal Chemistry Letters. 2:828-833

Novel type 1 phototherapeutic agents based on compounds containing S-N bonds (sulfenamides) were synthesized, assessed for free radical generation, and evaluated in vitro for cell death efficacy in four cancer cell lines (U937, HTC11, KB, and HT29).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffb90a37eafd09969ca4bb516fe51518
https://doi.org/10.1021/ml2001483

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Hydrophilic Pyrazine Dyes as Exogenous Fluorescent Tracer Agents for Real-Time Point-of-Care Measurement of Glomerular Filtration Rate

Autor: Kimberly R. Gaston, Amruta R. Poreddy, Jeng-Jong Shieh, William L. Neumann, Richard M. Fitch, Bethel Asmelash, Karen P. Galen, Raghavan Rajagopalan, Richard B. Dorshow, John N. Freskos

Publikováno v: Journal of Medicinal Chemistry. 54:5048-5058

Various hydrophilic pyrazine-bis(carboxamides) derived from 3,5-diamino-pyrazine-2,5-dicarboxylic acid bearing neutral and anionic groups were prepared and evaluated for use as fluorescent glomerular filtration rate (GFR) tracer agents. Among these,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04410b5155137c0cceaf4e9dd4eabefe
https://doi.org/10.1021/jm200257k

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Real-time point-of-care measurement of impaired renal function in a rat acute injury model employing exogenous fluorescent tracer agents

Autor: Jolette K. Wojdyla, Richard B. Dorshow, John N. Freskos, Karen P. Galen, Sevag Demirjian, Raghavan Rajagopalan, Richard M. Fitch, Jeng-Jong Shieh, Amruta R. Poreddy

Publikováno v: SPIE Proceedings.

Renal function assessment is needed for the detection of acute kidney injury and chronic kidney disease. Glomerular filtration rate (GFR) is now widely accepted as the best indicator of renal function, and current clinical guidelines advocate its use

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8b628fdcc43d5b12247e1926fc423e4a
https://doi.org/10.1117/12.2003078

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Correction to Type 1 Phototherapeutic Agents, Part I: Preparation and Cancer Cell Viability Studies of Novel Photolabile Sulfenamides

Autor: Bethel Asmelash, Raghavan Rajagopalan, Amolkumar Karwa, Richard B. Dorshow, Amruta R. Poreddy, Tien-Sung Lin

The original paper was published with a C rather than an S in the table of contents and abstract graphics. The correct structure is shown below.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4d8cb289828bba00018210fac5455e0
https://europepmc.org/articles/PMC4025766/

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Type 1 Phototherapeutic Agents. 2. Cancer Cell Viability and ESR Studies of Tricyclic Diarylamines

Autor: Amolkumar Karwa, Bethel Asmelash, Raghavan Rajagopalan, Amruta R. Poreddy, Richard B. Dorshow, Tien-Sung Lin

Publikováno v: ACS medicinal chemistry letters. 3(4)

Type 1 phototherapeutic agents based on diarylamines were assessed for free radical generation and evaluated in vitro for cell death efficacy in the U937 leukemia cancer cell line. All of the compounds were found to produce copious free radicals upon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fa9542978dff8c097c77298f1d63a83
https://pubmed.ncbi.nlm.nih.gov/24900465

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Development of fluorescent tracers for the real-time monitoring of renal function

Autor: J. Micah Wilcox, Bethel Asmelash, Rana Kumar, Richard M. Fitch, Karen P. Galen, Jeng-Jong Shieh, Jolette K. Wojdyla, Amruta R. Poreddy, James G. Kostelc, John N. Freskos, Raghavan Rajagopalan, William L. Neumann, Richard B. Dorshow, Tim A. Marzan, Kimberly R. Gaston, Martin P. Debreczeny, Tasha M. Schoenstein

Publikováno v: SPIE Proceedings.

Accurate measurement of glomerular filtration rate (GFR) at the bedside is highly desirable in order to assess renal function in real-time, which is currently an unmet clinical need. In our pursuit to develop exogenous fluorescent tracers as GFR mark

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::87fd694bf617e568f8adb4b6c01dd8f9
https://doi.org/10.1117/12.874917

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ChemInform Abstract: A Highly Efficient Method for the N-Alkylation of Aminopyrazines: Synthesis of Hydrophilic Red Fluorescent Dyes

Autor: Richard B. Dorshow, William L. Neumann, Amruta R. Poreddy, Bethel Asmelash

Publikováno v: ChemInform. 41

N,N′-Dialkylated aminopyrazines of type (V) are easily prepared by reductive alkylation with different aldehydes.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::27813da7833ebdf5f3b30454a5433c44
https://doi.org/10.1002/chin.201048155

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Novel visible light activated type 1 photosensitizers

Autor: Amolkumar Karwa, Przemyslaw Lusiak, Raghavan Rajagopalan, Gary L. Cantrell, Amruta R. Poreddy, Richard B. Dorshow, Raghoottama S. Pandurangi

Publikováno v: SPIE Proceedings.

Photodynamic therapy of tumors involving Type 2 photosenstizers has been conspicuously successful, but the Type 1 process, in contrast, has not received much attention despite its considerable potential. Accordingly, several classes of molecules cont

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7923e6e78f344149519c1d0be6c90f05
https://doi.org/10.1117/12.844970

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