Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Amro M Abdelrahman"'
Autor:
Linsey E. Jackson, Jennifer L. Tomlinson, Roberto Alva-Ruiz, Lindsey A. Gregory, Seul Kee Byeon, Amro M. Abdelrahman, Dong-Gi Mun, Caroline W. Grant, Zachary C. Fogarty, Chen Wang, Lewis R. Roberts, Rondell P. Graham, Mitesh J. Borad, Sumera I. Ilyas, Gregory J. Gores, Akhilesh Pandey, Arjun P. Athreya, Rory L. Smoot
Publikováno v:
JHEP Reports, Vol 6, Iss 6, Pp 101068- (2024)
Background & Aims: Metabolomic and lipidomic analyses provide an opportunity for novel biological insights. Cholangiocarcinoma (CCA) remains a highly lethal cancer with limited response to systemic, targeted, and immunotherapeutic approaches. Using a
Externí odkaz:
https://doaj.org/article/2c99399c263347e3bad6c6dcc1769f86
Autor:
Jaena Park, Janet E. Sorrells, Eric J. Chaney, Amro M. Abdelrahman, Jennifer A. Yonkus, Jennifer L. Leiting, Heidi Nelson, Jonathan J. Harrington, Edita Aksamitiene, Marina Marjanovic, Peter D. Groves, Colleen Bushell, Mark J. Truty, Stephen A. Boppart
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-12 (2023)
Abstract Pancreatic cancer is a devastating disease often detected at later stages, necessitating swift and effective chemotherapy treatment. However, chemoresistance is common and its mechanisms are poorly understood. Here, label-free multi-modal no
Externí odkaz:
https://doaj.org/article/caa8ab88d08344c5ae72a4306c96e8da
Autor:
Faizal Z. Asumda, Nellie A. Campbell, Mohamed A. Hassan, Reza Fathi, Daniella F. Vasquez Rico, Melanie Kiem, Ethan V. Vang, Yo Han Kim, Xin Luo, Daniel R. O’Brien, Sarah A. Buhrow, Joel M. Reid, Michael J. Moore, Vered Katz Ben-Yair, Mark L. Levitt, Jennifer L. Leiting, Amro M. Abdelrahman, Xinli Zhu, Fabrice Lucien, Mark J. Truty, Lewis R. Roberts
Publikováno v:
Cancers, Vol 16, Iss 5, p 1050 (2024)
Upamostat is an orally available small-molecule serine protease inhibitor that is a highly potent inhibitor of trypsin 1, trypsin 2, trypsin 3 (PRSS1/2/3), and the urokinase-type plasminogen activator (uPA). These enzymes are expressed in many cancer
Externí odkaz:
https://doaj.org/article/b28f6e53a90c47cf8ff9a1d3118f22b6
Autor:
Amro M. Abdelrahman, Jun Yin, Roberto Alva-Ruiz, Jennifer A. Yonkus, Jennifer L. Leiting, Isaac T. Lynch, Alessandro Fogliati, Nellie A. Campbell, Danielle M. Carlson, Lewis R. Roberts, Gregory J. Gores, Rory L. Smoot, Rondell P. Graham, Thorvardur R. Halfdanarson, Mark J. Truty
Publikováno v:
Cancers, Vol 15, Iss 3, p 840 (2023)
Mixed acinar neuroendocrine carcinoma of the pancreas (MANEC-P) is an extremely rare malignancy with a poor prognosis. However, epidemiological estimates of MANEC-P remain unknown. This study aimed to estimate and compare the incidence, prevalence, a
Externí odkaz:
https://doaj.org/article/3f8332a3d41c4fbaa4d6634738c0e703
Autor:
Feda H Hamdan, Amro M Abdelrahman, Ana Patricia Kutschat, Xin Wang, Thomas L Ekstrom, Nidhi Jalan-Sakrikar, Catherine Wegner Wippel, Negar Taheri, Liezel Tamon, Waltraut Kopp, Joana Aggrey-Fynn, Aditya V Bhagwate, Roberto Alva-Ruiz, Isaac Lynch, Jennifer Yonkus, Robyn Laura Kosinsky, Jochen Gaedcke, Stephan A Hahn, Jens T Siveke, Rondell Graham, Zeynab Najafova, Elisabeth Hessmann, Mark J Truty, Steven A Johnsen
Publikováno v:
Gut. 72:1174-1185
ObjectivePancreatic ductal adenocarcinoma (PDAC) displays a remarkable propensity towards therapy resistance. However, molecular epigenetic and transcriptional mechanisms enabling this are poorly understood. In this study, we aimed to identify novel
Autor:
Roberto Alva-Ruiz, Amro M. Abdelrahman, Patrick P. Starlinger, Jennifer A. Yonkus, David N. Moravec, Joel J. Busch, Chad J. Fleming, James C. Andrews, Bernardo C. Mendes, Jill J. Colglazier, Rory L. Smoot, Sean P. Cleary, David M. Nagorney, Michael L. Kendrick, Mark J. Truty
Publikováno v:
HPB. 24:1957-1966
Arterial resection (AR) for pancreatic adenocarcinoma is increasingly considered at specialized centers. We aimed to examine the incidence, risk factors, and outcomes of hepatic artery (HA) occlusion after revascularization.We included patients under
Autor:
Jennifer L. Leiting, Stephen J. Murphy, John R. Bergquist, Matthew C. Hernandez, Tommy Ivanics, Amro M. Abdelrahman, Lin Yang, Isaac Lynch, James B. Smadbeck, Sean P. Cleary, David M. Nagorney, Michael S. Torbenson, Rondell P. Graham, Lewis R. Roberts, Gregory J. Gores, Rory L. Smoot, Mark J. Truty
Publikováno v:
JHEP Reports, Vol 2, Iss 2, Pp - (2020)
Background & Aims: Biliary tract tumors are uncommon but highly aggressive malignancies with poor survival outcomes. Due to their low incidence, research into effective therapeutics has been limited. Novel research platforms for pre-clinical studies
Externí odkaz:
https://doaj.org/article/7980e146ca6b421f8c918ff7b4197c82
Autor:
Alessandro Fogliati, Guido Fiorentini, Roberto Alva-Ruiz, Amro M Abdelrahman, Andrea Zironda, Isaac T Lynch, Rory L Smoot, Patrick P Starlinger, Sean P Cleary, Michael L Kendrick, Mark J Truty
Publikováno v:
Journal of the American College of Surgeons.
Autor:
Jennifer A. Yonkus, Emma Whittle, Roberto Alva-Ruiz, Amro M. Abdelrahman, Susan E. Horsman, Gina A. Suh, Scott A. Cunningham, Heidi Nelson, Travis E. Grotz, Rory L. Smoot, Sean P. Cleary, David M. Nagorney, Michael L. Kendrick, Robin Patel, Mark J. Truty, Nicholas Chia
Publikováno v:
Surgery. 171:693-702
Surgical site infection is a major source of morbidity in patients undergoing pancreatic head resection and is often from organisms in intraoperative bile duct cultures. As such, many institutions use prolonged prophylactic antibiotics and tailor bas
Autor:
Roberto Alva-Ruiz, Robert R. McWilliams, Michael L. Kendrick, Jennifer A. Yonkus, David M. Nagorney, Wen Wee Ma, Travis E. Grotz, Christopher L. Hallemeier, Rondell P. Graham, Lavanya Yohanathan, Thorvadur R. Halfdanarson, Sean P. Cleary, Amit Mahipal, Rory L. Smoot, Lindsey A. Gregory, Amro M. Abdelrahman, Mark J. Truty
Publikováno v:
Annals of Surgical Oncology. 29:1579-1591
Background Neoadjuvant chemotherapy (NAC) is an integral part of preoperative treatment for patients with borderline resectable/locally advanced (BR/LA) pancreatic ductal adenocarcinoma (PDAC). The identification of a chemotherapeutic regimen that is