Zobrazeno 1 - 10
of 75
pro vyhledávání: '"Amro M Abdelrahman"'
Autor:
Roberto Alva‐Ruiz, Ryan D. Watkins, Jennifer L. Tomlinson, Jennifer A. Yonkus, Amro M. Abdelrahman, Caitlin B. Conboy, Erik Jessen, Nathan W. Werneburg, Hendrien Kuipers, Jack W. Sample, Gregory J. Gores, Sumera I. Ilyas, Mark J. Truty, Rory L. Smoot
Publikováno v:
FEBS Open Bio, Vol 14, Iss 11, Pp 1873-1887 (2024)
Cholangiocarcinoma (CCA) is a highly aggressive form of liver cancer and is an increasing cause of cancer‐related death worldwide. Despite its increasing incidence globally and alarming mortality, treatment options for CCA have largely remained unc
Externí odkaz:
https://doaj.org/article/c06dce51bdf6443f86bb9d8ffcc1a4dc
Autor:
Linsey E. Jackson, Jennifer L. Tomlinson, Roberto Alva-Ruiz, Lindsey A. Gregory, Seul Kee Byeon, Amro M. Abdelrahman, Dong-Gi Mun, Caroline W. Grant, Zachary C. Fogarty, Chen Wang, Lewis R. Roberts, Rondell P. Graham, Mitesh J. Borad, Sumera I. Ilyas, Gregory J. Gores, Akhilesh Pandey, Arjun P. Athreya, Rory L. Smoot
Publikováno v:
JHEP Reports, Vol 6, Iss 6, Pp 101068- (2024)
Background & Aims: Metabolomic and lipidomic analyses provide an opportunity for novel biological insights. Cholangiocarcinoma (CCA) remains a highly lethal cancer with limited response to systemic, targeted, and immunotherapeutic approaches. Using a
Externí odkaz:
https://doaj.org/article/2c99399c263347e3bad6c6dcc1769f86
Autor:
Jaena Park, Janet E. Sorrells, Eric J. Chaney, Amro M. Abdelrahman, Jennifer A. Yonkus, Jennifer L. Leiting, Heidi Nelson, Jonathan J. Harrington, Edita Aksamitiene, Marina Marjanovic, Peter D. Groves, Colleen Bushell, Mark J. Truty, Stephen A. Boppart
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-12 (2023)
Abstract Pancreatic cancer is a devastating disease often detected at later stages, necessitating swift and effective chemotherapy treatment. However, chemoresistance is common and its mechanisms are poorly understood. Here, label-free multi-modal no
Externí odkaz:
https://doaj.org/article/caa8ab88d08344c5ae72a4306c96e8da
Autor:
Feda H Hamdan, Amro M Abdelrahman, Ana Patricia Kutschat, Xin Wang, Thomas L Ekstrom, Nidhi Jalan-Sakrikar, Catherine Wegner Wippel, Negar Taheri, Liezel Tamon, Waltraut Kopp, Joana Aggrey-Fynn, Aditya V Bhagwate, Roberto Alva-Ruiz, Isaac Lynch, Jennifer Yonkus, Robyn Laura Kosinsky, Jochen Gaedcke, Stephan A Hahn, Jens T Siveke, Rondell Graham, Zeynab Najafova, Elisabeth Hessmann, Mark J Truty, Steven A Johnsen
Publikováno v:
Gut. 72:1174-1185
ObjectivePancreatic ductal adenocarcinoma (PDAC) displays a remarkable propensity towards therapy resistance. However, molecular epigenetic and transcriptional mechanisms enabling this are poorly understood. In this study, we aimed to identify novel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96374b93a79c5dd82550264fe249126b
https://doi.org/10.1136/gutjnl-2022-328154
https://doi.org/10.1136/gutjnl-2022-328154
Autor:
Jennifer L. Leiting, Stephen J. Murphy, John R. Bergquist, Matthew C. Hernandez, Tommy Ivanics, Amro M. Abdelrahman, Lin Yang, Isaac Lynch, James B. Smadbeck, Sean P. Cleary, David M. Nagorney, Michael S. Torbenson, Rondell P. Graham, Lewis R. Roberts, Gregory J. Gores, Rory L. Smoot, Mark J. Truty
Publikováno v:
JHEP Reports, Vol 2, Iss 2, Pp - (2020)
Background & Aims: Biliary tract tumors are uncommon but highly aggressive malignancies with poor survival outcomes. Due to their low incidence, research into effective therapeutics has been limited. Novel research platforms for pre-clinical studies
Externí odkaz:
https://doaj.org/article/7980e146ca6b421f8c918ff7b4197c82
Autor:
Roberto Alva-Ruiz, Amro M. Abdelrahman, Patrick P. Starlinger, Jennifer A. Yonkus, David N. Moravec, Joel J. Busch, Chad J. Fleming, James C. Andrews, Bernardo C. Mendes, Jill J. Colglazier, Rory L. Smoot, Sean P. Cleary, David M. Nagorney, Michael L. Kendrick, Mark J. Truty
Publikováno v:
HPB. 24:1957-1966
Arterial resection (AR) for pancreatic adenocarcinoma is increasingly considered at specialized centers. We aimed to examine the incidence, risk factors, and outcomes of hepatic artery (HA) occlusion after revascularization.We included patients under
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37158bce2294f11ef78d31644efec669
https://doi.org/10.1016/j.hpb.2022.06.005
https://doi.org/10.1016/j.hpb.2022.06.005
Autor:
Alessandro Fogliati, Guido Fiorentini, Roberto Alva-Ruiz, Amro M Abdelrahman, Andrea Zironda, Isaac T Lynch, Rory L Smoot, Patrick P Starlinger, Sean P Cleary, Michael L Kendrick, Mark J Truty
Publikováno v:
Journal of the American College of Surgeons.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be4bedb0270c79d87434763cdac011c5
https://doi.org/10.1097/xcs.0000000000000744
https://doi.org/10.1097/xcs.0000000000000744
Autor:
Jennifer A. Yonkus, Emma Whittle, Roberto Alva-Ruiz, Amro M. Abdelrahman, Susan E. Horsman, Gina A. Suh, Scott A. Cunningham, Heidi Nelson, Travis E. Grotz, Rory L. Smoot, Sean P. Cleary, David M. Nagorney, Michael L. Kendrick, Robin Patel, Mark J. Truty, Nicholas Chia
Publikováno v:
Surgery. 171:693-702
Surgical site infection is a major source of morbidity in patients undergoing pancreatic head resection and is often from organisms in intraoperative bile duct cultures. As such, many institutions use prolonged prophylactic antibiotics and tailor bas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69fd85e01090250827f82fe933db7ec8
https://doi.org/10.1016/j.surg.2021.09.037
https://doi.org/10.1016/j.surg.2021.09.037
Autor:
Roberto Alva-Ruiz, Robert R. McWilliams, Michael L. Kendrick, Jennifer A. Yonkus, David M. Nagorney, Wen Wee Ma, Travis E. Grotz, Christopher L. Hallemeier, Rondell P. Graham, Lavanya Yohanathan, Thorvadur R. Halfdanarson, Sean P. Cleary, Amit Mahipal, Rory L. Smoot, Lindsey A. Gregory, Amro M. Abdelrahman, Mark J. Truty
Publikováno v:
Annals of Surgical Oncology. 29:1579-1591
Background Neoadjuvant chemotherapy (NAC) is an integral part of preoperative treatment for patients with borderline resectable/locally advanced (BR/LA) pancreatic ductal adenocarcinoma (PDAC). The identification of a chemotherapeutic regimen that is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::85012df1fc0fbb01e8395b882ec46e8f
https://doi.org/10.1245/s10434-021-10991-2
https://doi.org/10.1245/s10434-021-10991-2
Autor:
Aradhana Kasimsetty, Elzbieta Lenkiewicz, James M Bogenberger, Jan B. Egan, Bolni Marius Nagalo, Smriti Malasi, Mitesh J. Borad, Pedro L.S. Uson, Heidi E. Kosiorek, Jennifer L. Leiting, Marcela Salomao, Amro M. Abdelrahman, Mark J. Truty, Mansi Arora, Michael T. Barrett, Esteban Braggio, Yumei Zhou, Xianfeng Chen
Publikováno v:
Cancer Chemotherapy and Pharmacology. 85:1063-1078
NUC1031 is a first-in-class ProTide, that is a gemcitabine pro-drug designed to overcome putative mechanisms of resistance, including decreased expression of hENT/hCNT transporters, absence of activating enzymes such as deoxycytidine kinase (dCK) and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2b97e5bb82889445d5fa8b8904ed3131
https://doi.org/10.1007/s00280-020-04079-z
https://doi.org/10.1007/s00280-020-04079-z