Zobrazeno 1 - 10
of 138
pro vyhledávání: '"Amro, Aboukameel"'
Autor:
Md. Hafiz Uddin, Mohammad Najeeb Al‐Hallak, Husain Yar Khan, Amro Aboukameel, Yiwei Li, Sahar F. Bannoura, Gregory Dyson, Seongho Kim, Yosef Mzannar, Ibrahim Azar, Tanya Odisho, Amr Mohamed, Yosef Landesman, Steve Kim, Rafic Beydoun, Ramzi M. Mohammad, Philip A. Philip, Anthony F. Shields, Asfar S. Azmi
Publikováno v:
Clinical and Translational Medicine, Vol 13, Iss 12, Pp n/a-n/a (2023)
Abstract Background The majority of pancreatic ductal adenocarcinoma (PDAC) patients experience disease progression while on treatment with gemcitabine and nanoparticle albumin‐bound (nab)‐paclitaxel (GemPac) necessitating the need for a more eff
Externí odkaz:
https://doaj.org/article/746a7f24c49c48c5878e393d3f6d9f55
Autor:
Husain Yar Khan, PhD, Mandana Kamgar, MD, Amro Aboukameel, MS, Sahar Bannoura, MS, Brian Y. Chung, PhD, Yiwei Li, MD, Mohammed Najeeb Al Hallak, MD, Philip A. Philip, MD, PhD, Susan Tsai, MD, Sanjeev Luther, MBA, William A. Hall, MD, Asfar S. Azmi, PhD
Publikováno v:
Advances in Radiation Oncology, Vol 8, Iss 1, Pp 101122- (2023)
Purpose: Local tumor progression is a cause of significant morbidity and mortality in patients with pancreatic ductal adenocarcinoma (PDAC) with surgically unresectable disease. Novel and effective approaches to accomplish durable local control are u
Externí odkaz:
https://doaj.org/article/ee77f111869b4d7c8620b432196590f6
Autor:
Irfana Muqbil, Mahmoud Chaker, Amro Aboukameel, Ramzi M. Mohammad, Asfar S. Azmi, Radhakrishanan Ramchandren
Publikováno v:
Heliyon, Vol 5, Iss 8, Pp e02290- (2019)
Bruton's Tyrosine Kinase (BTK) is a member of the TEC family and plays a central role in B-cell signaling, activation, proliferation and differentiation. Here we evaluated the impact of BTK inhibitor Ibrutinib on a panel of HL models in vitro and in
Externí odkaz:
https://doaj.org/article/b8d409bca9604bfd9934100210309533
Autor:
Asfar S. Azmi, Anthony F. Shields, Ramzi M. Mohammad, Philip A. Philip, Dipesh Uprety, Hirva Mamdani, Yosef Landesman, Rafic Beydoun, Steve Kim, Mohammed Najeeb Al-Hallak, Yousef Mzannar, Sahar Bannoura, Rachel Sexton, Md. Hafiz Uddin, Amro Aboukameel, Yiwei Li, Misako Nagasaka, Husain Yar Khan
Supplementary Figure 1. XPO1-KRAS synthetic lethal interaction identified using the Slorth database. Supplementary Figure 2. KRAS WT, KRAS G12D and KRAS G12V MEF cell lines were refractory to growth inhibition by selinexor or MRTX1257 or their combin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b8baa9b3cbc288ae8a6d95ae6fcdd3d
https://doi.org/10.1158/2767-9764.22544132.v1
https://doi.org/10.1158/2767-9764.22544132.v1
Autor:
Asfar S. Azmi, Anthony F. Shields, Ramzi M. Mohammad, Philip A. Philip, Dipesh Uprety, Hirva Mamdani, Yosef Landesman, Rafic Beydoun, Steve Kim, Mohammed Najeeb Al-Hallak, Yousef Mzannar, Sahar Bannoura, Rachel Sexton, Md. Hafiz Uddin, Amro Aboukameel, Yiwei Li, Misako Nagasaka, Husain Yar Khan
The identification of molecules that can bind covalently to KRAS G12C and lock it in an inactive GDP-bound conformation has opened the door to targeting KRAS G12C selectively. These agents have shown promise in preclinical tumor models and clinical t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::718acd53ed3f4593886fb1335899dd3c
https://doi.org/10.1158/2767-9764.c.6550541
https://doi.org/10.1158/2767-9764.c.6550541
Autor:
Asfar S. Azmi, Ramzi M. Mohammad, Philip A. Philip, Michael Kauffman, Sharon Shacham, Yosef Landesman, Erkan Baloglu, William Senapedis, Irfana Muqbil, Amro Aboukameel
Supplementary Figure1. IC50 analysis for PAM activity across a panel of cell lines. MTT assay was performed at 72 hrs; Supplementary Figure 2. PDAC cell lines were grown at a density of 50,000 cells per well overnight and exposed to PAMs (at 5000 nM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cea604e2f0c5f600d777bee8f0f5b66
https://doi.org/10.1158/1535-7163.22508211
https://doi.org/10.1158/1535-7163.22508211
Autor:
Asfar S. Azmi, Ramzi M. Mohammad, Philip A. Philip, Bassel F. El-Rayes, Nerissa T. Viola, Kay-Uwe Wagner, Yosef Landesman, William T. Senapedis, Erkan Baloglu, Gregory Dyson, Rafic Beydoun, Steve H. Kim, Yiwei Li, Amro Aboukameel, Mohammed N. Al-Hallak, Md. Hafiz Uddin, Gabriel B. Mpilla
Metastatic pancreatic neuroendocrine tumors (PNET) remain an unmet clinical problem. Chronologic treatment in PNETs includes observation (watchful protocol), surgery, targeted therapy, and chemotherapy. However, increasing evidence illustrates that t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::174f2675208c5e838760dd90c77538d9
https://doi.org/10.1158/1535-7163.c.6542856.v1
https://doi.org/10.1158/1535-7163.c.6542856.v1
Autor:
Zaneta Nikolovska-Coleska, Ramzi M. Mohammad, Jeanne A. Stuckey, Duxin Sun, Tao Zhang, Scott Owens, Tomasz Cierpicki, Thippeswamy Gulappa, Ahmed S.A. Mady, Amro Aboukameel, Asfar S. Azmi, Meilan Liu, Chenzhong Liao, Fardokht Abulwerdi
PDF - 3347KB, Synthesis and characterization of the lead compound 1 (UMI-59) and its analog 2 (UMI-77), additional details for used methods, and nine supplementary figures.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d2ebe7752694e8e0d74d2d706ad75de
https://doi.org/10.1158/1535-7163.22500082.v1
https://doi.org/10.1158/1535-7163.22500082.v1
Autor:
Asfar S. Azmi, Ramzi M. Mohammad, Philip A. Philip, Bassel F. El-Rayes, Nerissa T. Viola, Kay-Uwe Wagner, Yosef Landesman, William T. Senapedis, Erkan Baloglu, Gregory Dyson, Rafic Beydoun, Steve H. Kim, Yiwei Li, Amro Aboukameel, Mohammed N. Al-Hallak, Md. Hafiz Uddin, Gabriel B. Mpilla
Supplementary Figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c97be78d8516026844611d31d8514695
https://doi.org/10.1158/1535-7163.22520970
https://doi.org/10.1158/1535-7163.22520970
Autor:
Zaneta Nikolovska-Coleska, Ramzi M. Mohammad, Jeanne A. Stuckey, Duxin Sun, Tao Zhang, Scott Owens, Tomasz Cierpicki, Thippeswamy Gulappa, Ahmed S.A. Mady, Amro Aboukameel, Asfar S. Azmi, Meilan Liu, Chenzhong Liao, Fardokht Abulwerdi
Using a high-throughput screening (HTS) approach, we have identified and validated several small-molecule Mcl-1 inhibitors (SMI). Here, we describe a novel selective Mcl-1 SMI inhibitor, 2 (UMI-77), developed by structure-based chemical modifications
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::486b43ad56418f83c2937c579d90f8f3
https://doi.org/10.1158/1535-7163.c.6536347
https://doi.org/10.1158/1535-7163.c.6536347