Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Amrita Kamat"'
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
Neuronal function and their survival depend on the activation of ion channels. Loss of ion channel function is known to induce neurodegenerative diseases such as Parkinson’s that exhibit loss of dopaminergic neurons; however, mechanisms that could
Externí odkaz:
https://doaj.org/article/a8005d6fa8c74a2b9319ca19b1403297
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e32746 (2012)
Diabetic nephropathy is a serious complication of longstanding diabetes and its pathogenesis remains unclear. Oxidative stress may play a critical role in the pathogenesis and progression of diabetic nephropathy. Our previous studies have demonstrate
Externí odkaz:
https://doaj.org/article/be19d5019747463f9bfd7f421b23f9ae
Autor:
Jennifer Adjei‐Mosi, Qing Sun, Steven Blake Smithson, Gavyn Lee Shealy, Krupa Dhruvitha Amerineni, Zerong Liang, Hanqing Chen, Mei Wang, Qinggong Ping, Jingyan Han, Masahiro Morita, Amrita Kamat, Nicolas Musi, Mengwei Zang
Publikováno v:
Aging Cell. 22
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6091f0b2928a5b7dd1df06e796cddb07
https://doi.org/10.1111/acel.13811
https://doi.org/10.1111/acel.13811
Autor:
Feng Liu, Senlin Li, Huan Xu, Ye Zhang, Feng Dong, Cang Chen, Xiaoban Xin, Jared L Zhao, Jason T Hadley, Robin J. Leach, Muhammad A. Abdul-Ghani, Jiyoon Ryu, Xiaoning Guo, Zhi Li, Ralph A. DeFronzo, Lily Q. Dong, Amrita Kamat
Publikováno v:
Diabetes. 70:1303-1316
Adiponectin is an adipokine that exerts insulin-sensitizing and anti-inflammatory roles in insulin target tissues including liver. While the insulin-sensitizing function of adiponectin has been extensively investigated, the precise mechanism by which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::642f25fc2f6faac3459e719f64e3d4f3
https://doi.org/10.2337/db20-1073
https://doi.org/10.2337/db20-1073
Autor:
Jeffrey L. Barnes, Falguni Das, Yun Shi, Jason Pizzini, Hanzhou Wang, Goutam Ghosh Choudhury, Amrita Kamat, Michael S. Katz, Parveez Ahamed Abdul Azees, Chih Ko Yeh, Mengwei Zang, Susan T. Weintraub
Publikováno v:
Am J Physiol Endocrinol Metab
Nonalcoholic fatty liver disease (NAFLD) is a spectrum of disorders ranging from hepatic steatosis [excessive accumulation of triglycerides (TG)] to nonalcoholic steatohepatitis, which can progress to cirrhosis and hepatocellular carcinoma. The molec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a01d415da16e0cd59ec5654ae311abb
https://europepmc.org/articles/PMC8321826/
https://europepmc.org/articles/PMC8321826/
Autor:
Nandini Ghosh-Choudhury, Amrita Kamat, Falguni Das, Kavitha Sataranatarajan, Goutam Ghosh Choudhury, Balakuntalam S. Kasinath, Amit Bera
Publikováno v:
Cellular signalling. 86
Function of mTORC1 and mTORC2 has emerged as a driver of mesangial cell pathologies in diabetic nephropathy. The mechanism of mTOR activation is poorly understood in this disease. Deptor is a constitutive subunit and a negative regulator of both mTOR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a7c83f843b8a598a0e1754d290b592b
https://pubmed.ncbi.nlm.nih.gov/34224844
https://pubmed.ncbi.nlm.nih.gov/34224844
Autor:
Gail D. Lewis, Guangmin Li, Jun Guo, Shang-Fan Yu, Carter T. Fields, Genee Lee, Donglu Zhang, Peter S. Dragovich, Thomas Pillow, BinQing Wei, Jack Sadowsky, Douglas Leipold, Tim Wilson, Amrita Kamath, Michael Mamounas, M. Violet Lee, Ola Saad, Voleak Choeurng, Alexander Ungewickell, Sharareh Monemi, Lisa Crocker, Kevin Kalinsky, Shanu Modi, Kyung Hae Jung, Erika Hamilton, Patricia LoRusso, Ian Krop, Melissa M. Schutten, Renee Commerford, Mark X. Sliwkowski, Eunpi Cho
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Approved antibody-drug conjugates (ADCs) for HER2-positive breast cancer include trastuzumab emtansine and trastuzumab deruxtecan. To develop a differentiated HER2 ADC, we chose an antibody that does not compete with trastuzumab or pertuzuma
Externí odkaz:
https://doaj.org/article/654b41b090ea4a87be21fb42ec554dae
Autor:
Zhe Dai, Yang Xiao, Kun Dong, Zhi Li, Feng Liu, Amanda K. Galan-Davila, Qunfeng Dong, Jiyoon Ryu, Min Lu, Deling Zhang, Amanda M. Dick, Lily Q. Dong, Amrita Kamat, Kevin D. Liu
Publikováno v:
Journal of Biological Chemistry. 293:6064-6074
Adiponectin is an adipocyte-derived hormone with antidiabetic activities that include increasing the sensitivity of cells to insulin. Adaptor protein containing pleckstrin homology domain, phosphotyrosine-binding domain, and leucine zipper motif (APP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62c7e93d9efd61a2bb1b072af140fe81
https://doi.org/10.1074/jbc.ra118.002162
https://doi.org/10.1074/jbc.ra118.002162
Autor:
Jeffrey L. Barnes, Michael S. Katz, Amrita Kamat, Yun Shi, Paramita M. Ghosh, Hanzhou Wang, Chih Ko Yeh, Zhen Ju Shu
Publikováno v:
American journal of physiology. Regulatory, integrative and comparative physiology, vol 314, iss 4
Increased β-adrenergic receptor (β-AR)-mediated activation of adenylyl cyclase (AC) in rat liver during aging has been linked to age-related increases in hepatic glucose output and hepatosteatosis. In this study, we investigated the expression of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba6397e3000c959c2d4d3b029dfbb56e
https://doi.org/10.1152/ajpregu.00372.2017
https://doi.org/10.1152/ajpregu.00372.2017
Publikováno v:
Journal of the Endocrine Society
The objective of the proposed study is to investigate the feasibility of the marmoset as an animal model to study age-associated nonalcoholic fatty liver disease (NAFLD). This chronic liver disease includes a spectrum of disorders ranging from increa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22320ee6407be4da8135d6e4e188926a
http://europepmc.org/articles/PMC8266042
http://europepmc.org/articles/PMC8266042