Zobrazeno 1 - 10
of 160
pro vyhledávání: '"Amrit, Paudel"'
Publikováno v:
Pharmaceuticals, Vol 17, Iss 10, p 1290 (2024)
Background/Objectives: This study compared two pilot scale continuous manufacturing methods of solid self-emulsifying drug delivery systems (SEDDSs) via hot melt extrusion (HME). Methods: A model poorly water-soluble drug carvedilol in low dose (0.5
Externí odkaz:
https://doaj.org/article/1108be39709042c6939e14cf53d9ac82
Publikováno v:
Pharmaceutics, Vol 16, Iss 8, p 1035 (2024)
The present study investigated the effect of different polymers and manufacturing methods (hot melt extrusion, HME, and spray drying, SD) on the solid state, stability and pharmaceutical performance of amorphous solid dispersions. In the present manu
Externí odkaz:
https://doaj.org/article/9ac1148e568642bf9178ce40c91e3879
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 11 (2023)
Over the past several decades, there has been significant growth in the design and development of more efficient and advanced biomaterials based on non-cellulosic biological macromolecules. In this context, hydrogels based on stimuli-responsive non-c
Externí odkaz:
https://doaj.org/article/07ea951458c54f5c8cc1fdcb0307dd1b
Publikováno v:
Radiology Case Reports, Vol 17, Iss 12, Pp 4652-4655 (2022)
Carcinoma prostate is the second most common cancer in men after skin cancer. It is the most common visceral malignancy in the United States of America. Like any other cancerous lesion, it has the propensity to metastasize to any part of the body; th
Externí odkaz:
https://doaj.org/article/10bdacf326624aad8086370951c3d6ee
Publikováno v:
Pharmaceutics, Vol 15, Iss 10, p 2504 (2023)
While using saccharides as stabilizers for therapeutic protein drying is common, the mechanisms underlying the stabilization during drying remain largely unexplored. Herein, we investigated the effect of different saccharides, trehalose dihydrate (TD
Externí odkaz:
https://doaj.org/article/fc1ee4d6e9c24076928b85f0efb4245a
Autor:
Jayant Iyer, Anjali Karn, Michael Brunsteiner, Andrew Ray, Adrian Davis, Isha Saraf, Amrit Paudel
Publikováno v:
Pharmaceutics, Vol 15, Iss 3, p 848 (2023)
Oxidative degradation of drugs is one of the major routes of drug substance and drug product instability. Among the diverse routes of oxidation, autoxidation is considered to be challenging to predict and control, potentially due to the multi-step me
Externí odkaz:
https://doaj.org/article/4ca6497495894bff8569175abc19a971
Autor:
Elisabeth Fink, Michael Brunsteiner, Stefan Mitsche, Hartmuth Schröttner, Amrit Paudel, Sarah Zellnitz-Neugebauer
Publikováno v:
Pharmaceutics, Vol 15, Iss 2, p 347 (2023)
Co-amorphous systems (COAMS) have raised increasing interest in the pharmaceutical industry, since they combine the increased solubility and/or faster dissolution of amorphous forms with the stability of crystalline forms. However, the choice of the
Externí odkaz:
https://doaj.org/article/0973c790c94149b094e60132fa7be065
Publikováno v:
International Journal of Pharmaceutics: X, Vol 3, Iss , Pp 100084- (2021)
Following our study on the impact of hot melt extrusion (HME) process conditions on the product quality, we expanded our investigation to assessing the effect of scale-up on the product quality. To this end, we studied the influence of process settin
Externí odkaz:
https://doaj.org/article/934bfc52759b4cbf95789c268a659fed
Autor:
Ožbej Zupančič, Aygün Doğan, Josip Matić, Varun Kushwah, Carolina Alva, Martin Spoerk, Amrit Paudel
Publikováno v:
Pharmaceutics, Vol 14, Iss 12, p 2617 (2022)
The aim of this study was to develop a continuous pilot-scale solidification and characterization of self-emulsifying drug delivery systems (SEDDSs) via hot melt extrusion (HME) using Soluplus® and Kollidon® VA-64. First, an oil-binding capacity st
Externí odkaz:
https://doaj.org/article/ea13b65e67b44a06aa91a14b448be07f
Publikováno v:
F1000Research, Vol 10 (2021)
Sarcomatoid carcinoma of the lung is an uncommon subtype of non-small-cell lung cancer (NSCLC). Even in the early stages, pulmonary sarcomatoid carcinoma (PSC) has a dismal prognosis when compared to other kinds of NSCLC with a mean survival of 9–1
Externí odkaz:
https://doaj.org/article/93b84f9e3f8f4aa79a255e8e6de5dd6e