Zobrazeno 1 - 10
of 496
pro vyhledávání: '"Amrik Sahota"'
Autor:
Lei Chen, Shirley Luo, Abigail Dupre, Roshan P. Vasoya, Aditya Parthasarathy, Rohit Aita, Raj Malhotra, Joseph Hur, Natalie H. Toke, Eric Chiles, Min Yang, Weihuan Cao, Juan Flores, Christopher E. Ellison, Nan Gao, Amrik Sahota, Xiaoyang Su, Edward M. Bonder, Michael P. Verzi
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Brush border gene regulation in various different tissues is incompletely understood. Here, the authors show HNF4 regulates the brush border gene program in multiple organs, such as intestine, kidney and yolk sac, and also intestinal chromatin loopin
Externí odkaz:
https://doaj.org/article/5b2c764533374b2391e6fb24a9437a11
Autor:
Lauren E. Woodard, Richard C. Welch, Ruth Ann Veach, Thomas M. Beckermann, Feng Sha, Edward J. Weinman, Talat Alp Ikizler, Jay A. Tischfield, Amrik Sahota, Matthew H. Wilson
Publikováno v:
BMC Nephrology, Vol 20, Iss 1, Pp 1-9 (2019)
Abstract Background Cystinuria is an inherited disorder of renal amino acid transport that causes recurrent nephrolithiasis and significant morbidity in humans. It has an incidence of 1 in 7000 worldwide making it one of the most common genetic disor
Externí odkaz:
https://doaj.org/article/34f494f6358f467691d7f610d71a6800
Publikováno v:
Medicinal Chemistry Research.
Publikováno v:
Accounts of Chemical Research. 55:516-525
Aberrant crystallization within the human body can lead to several disease states or adverse outcomes, yet much remains to be understood about the critical stages leading to these events, which can include crystal nucleation and growth, crystal aggre
Autor:
Diana Stachula, Amrik Sahota
Publikováno v:
Aresty Rutgers Undergraduate Research Journal. 1
This review provides an overview of the genetic aspects of cystinuria, as well as the novel pharmacotherapeutics that could potentially be used to treat the disease. Cystinuria is an inherited disorder characterized by the formation of painful stones
Autor:
Weihuan Cao, Joseph Hur, Christopher E. Ellison, Raj Malhotra, Roshan P. Vasoya, Abigail Dupre, Min Yang, Juan Flores, Michael P. Verzi, Amrik Sahota, Aditya Parthasarathy, Lei Chen, Eric Chiles, Rohit Aita, Nan Gao, Natalie H. Toke, Shirley Luo, Edward M. Bonder, Xiaoyang Su
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications
Nature Communications
The brush border is comprised of microvilli surface protrusions on the apical surface of epithelia. This specialized structure greatly increases absorptive surface area and plays crucial roles in human health. However, transcriptional regulatory netw
Autor:
Matthew H. Wilson, Jay A. Tischfield, Edward J. Weinman, Amrik Sahota, Thomas M. Beckermann, Lauren E. Woodard, Feng Sha, Talat Alp Ikizler, Ruth Ann Veach, Richard Welch
Publikováno v:
BMC Nephrology
BMC Nephrology, Vol 20, Iss 1, Pp 1-9 (2019)
BMC Nephrology, Vol 20, Iss 1, Pp 1-9 (2019)
Background Cystinuria is an inherited disorder of renal amino acid transport that causes recurrent nephrolithiasis and significant morbidity in humans. It has an incidence of 1 in 7000 worldwide making it one of the most common genetic disorders in m
Autor:
Anthony C. Yu, Nelson Garcia-Vázquez, Laura N. Poloni, David M. Connors, Michael D. Ward, Amrik Sahota, Zina Zhu, Alexander G. Shtukenberg, Longqin Hu
Publikováno v:
Crystal Growth & Design
l-Cystine kidney stones—aggregates of single crystals of the hexagonal form of l-cystine—afflict more than 20 000 individuals in the United States alone. Current therapies are often ineffective and produce adverse side effects. Recognizing that t
Publikováno v:
Urolithiasis. 47(1)
Cystinuria, a genetic disorder of cystine transport, is characterized by excessive excretion of cystine in the urine and recurrent cystine stones in the kidneys and, to a lesser extent, in the bladder. Males generally are more severely affected than
Autor:
Amrik Sahota, Jian Jie Liang, Herve Aloysius, Haifa Albanyan, Vladyslav Kholodovych, Sumi Lee, Longqin Hu, Yanhui Yang
Publikováno v:
Bioorganicmedicinal chemistry letters. 28(8)
To overcome the chemical and metabolic stability issues of L-cystine dimethyl ester (CDME) and L-cystine methyl ester (CME), a series of L-cystine diamides with or without N(α)-methylation was designed, synthesized, and evaluated for their inhibitor