Zobrazeno 1 - 10 of 22 pro vyhledávání: '"Amreena, Suri"'
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Akademický článek
Reversal of cancer gene expression identifies repurposed drugs for diffuse intrinsic pontine glioma
Autor: Guisheng Zhao, Patrick Newbury, Yukitomo Ishi, Eugene Chekalin, Billy Zeng, Benjamin S. Glicksberg, Anita Wen, Shreya Paithankar, Takahiro Sasaki, Amreena Suri, Javad Nazarian, Michael E. Pacold, Daniel J. Brat, Theodore Nicolaides, Bin Chen, Rintaro Hashizume
Publikováno v: Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-15 (2022)
Abstract Diffuse intrinsic pontine glioma (DIPG) is an aggressive incurable brainstem tumor that targets young children. Complete resection is not possible, and chemotherapy and radiotherapy are currently only palliative. This study aimed to identify
Externí odkaz: https://doaj.org/article/f3332d0634814614963f2bd110095917
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2
Intranasal delivery of nanoliposomal SN-38 for treatment of diffuse midline glioma
Autor: Takahiro, Sasaki, Jun, Watanabe, Xingyao, He, Hiroaki, Katagi, Amreena, Suri, Yukitomo, Ishi, Kouki, Abe, Manabu, Natsumeda, William H, Frey, Peng, Zhang, Rintaro, Hashizume
Publikováno v: Journal of Neurosurgery. :1-10
OBJECTIVE Diffuse midline gliomas, including diffuse intrinsic pontine gliomas (DIPGs), are among the most malignant and devastating childhood brain cancers. Despite aggressive treatment, nearly all children with these tumors succumb to their disease
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3b0c66b7ec580c5c1f1c611285690ea
https://doi.org/10.3171/2022.9.jns22715
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3
Data from Therapeutic Targeting of EZH2 and BET BRD4 in Pediatric Rhabdoid Tumors
Autor: Rintaro Hashizume, Ali Shilatifard, Lihua Zou, Manabu Natsumeda, Pankaj Bhalla, Hiroaki Katagi, Xingyao He, Kouki Abe, Jun Watanabe, Amreena Suri, Andrea Piunti, Takahiro Sasaki, Ali Zhang, Yongzhan Zhang, Yukitomo Ishi
Aberrant activity of the H3K27 modifiers EZH2 and BRD4 is an important oncogenic driver for atypical teratoid/rhabdoid tumor (AT/RT), and each is potentially a possible therapeutic target for treating AT/RT. We, therefore, determined whether targetin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fb7901f818e8683a1c0dffc1b6ae96b
https://doi.org/10.1158/1535-7163.c.6543226.v1
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6
Therapeutic Targeting of EZH2 and BET BRD4 in Pediatric Rhabdoid Tumors
Autor: Yukitomo Ishi, Yongzhan Zhang, Ali Zhang, Takahiro Sasaki, Andrea Piunti, Amreena Suri, Jun Watanabe, Kouki Abe, Xingyao He, Hiroaki Katagi, Pankaj Bhalla, Manabu Natsumeda, Lihua Zou, Ali Shilatifard, Rintaro Hashizume
Publikováno v: Mol Cancer Ther
Aberrant activity of the H3K27 modifiers EZH2 and BRD4 is an important oncogenic driver for atypical teratoid/rhabdoid tumor (AT/RT), and each is potentially a possible therapeutic target for treating AT/RT. We, therefore, determined whether targetin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ab24cec9b1731f3857f748ebff79d17
https://doi.org/10.1158/1535-7163.mct-21-0646
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7
Design, synthesis and evaluation of novel indole-2-carboxamides for growth inhibition of Mycobacterium tuberculosis and paediatric brain tumour cells
Autor: Chiang Ching Huang, Shahinda S.R. Alsayed, Mauro Mocerino, Anders W. Bailey, Simone Treiger Sredni, Amreena Suri, William R. Bishai, Hendra Gunosewoyo, Alan D. Payne, Shichun Lun
Publikováno v: RSC Advances. 11:15497-15511
The omnipresent threat of tuberculosis (TB) and the scant treatment options thereof necessitate the development of new antitubercular agents, preferably working via a novel mechanism of action distinct from the current drugs. Various studies identifi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7bd1b920cc35180da9b59f3c8a73dc27
https://doi.org/10.1039/d0ra10728j
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8
EXTH-29. RADIOSENSITIZATION BY BRD4 INHIBITION IN DIFFUSE INTRINSIC PONTINE GLIOMA
Autor: Jun Watanabe, Matt Clutter, Amreena Suri, Koki Abe, Yukitomo Ishi, Oren Becher, Rintaro Hashizume
Publikováno v: Neuro-Oncology. 24:vii215-vii216
Diffuse intrinsic pontine glioma (DIPG), the most frequent brainstem tumor in pediatrics, is one of the devastating childhood cancers, and virtually all patients die within two years after diagnosis. Since these tumors occur in the brainstem which is
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f876471c4f338bed20feee19dc001537
https://doi.org/10.1093/neuonc/noac209.828
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9
Akademický článek
Polo-Like Kinase 4 (PLK4) Is Overexpressed in Central Nervous System Neuroblastoma (CNS-NB)
Autor: Anders W. Bailey, Amreena Suri, Pauline M. Chou, Tatiana Pundy, Samantha Gadd, Stacey L. Raimondi, Tadanori Tomita, Simone Treiger Sredni
Publikováno v: Bioengineering, Vol 5, Iss 4, p 96 (2018)
Neuroblastoma (NB) is the most common extracranial solid tumor in pediatrics, with rare occurrences of primary and metastatic tumors in the central nervous system (CNS). We previously reported the overexpression of the polo-like kinase 4 (PLK4) in em
Externí odkaz: https://doaj.org/article/11ff6acefb154c15bbb4c8121a6cac3a
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10
EXTH-08. DEVELOPMENT OF NOVEL HISTONE DEMETHYLASE INHIBITOR AGAINST DIPG
Autor: Amreena Suri, Srinivasan Venkatesan, Takahiro Sasaki, Yukitomo Ishi, Jun Watanabe, Kouki Abe, Frank H Ebetino, Alison J Frontier, Rintaro Hashizume
Publikováno v: Neuro-Oncology. 24:vii210-vii210
BACKGROUND Diffuse intrinsic pontine glioma (DIPG) is one of most the devastating pediatric brain tumors, and virtually all patients die within two years after diagnosis. It has been shown that targeted inhibition of JMJD3 demethylase activity by GSK
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c2a025e4d9add1314d103edfd5062ae4
https://doi.org/10.1093/neuonc/noac209.807
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