Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Amram Torgeman"'
Autor:
Alon Ben David, Ada Barnea, Amram Torgeman, Eran Diamant, Eyal Dor, Arieh Schwartz, Osnat Rosen, Noa Caspi, Miki Saraf, Elad Lerer, Yaakov Adar, Edith Lupo, Einat Toister, Ran Zichel
Publikováno v:
Vaccines, Vol 10, Iss 9, p 1522 (2022)
Botulism is a paralytic disease caused by botulinum neurotoxins (BoNTs). Equine antitoxin is currently the standard therapy for botulism in human. The preparation of equine antitoxin relies on the immunization of horses with botulinum toxoid, which s
Externí odkaz:
https://doaj.org/article/d1103dc01bdb44bdb659a7574f5ac830
Autor:
Eyal Dor, Tseela David, Hani Dekel Jaoui, Arieh Schwartz, Tzadok Baruchi, Amram Torgeman, Alon Ben David, Osnat Rosen, Arnon Tal, Amir Rosner, Ran Zichel, Eran Diamant
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Medical treatment may require the continuous intravenous (IV) infusion of drugs to sustain the therapeutic blood concentration and to minimize dosing errors. Animal disease models that ultimately mimic the intended use of new potential drugs via a co
Externí odkaz:
https://doaj.org/article/cbe9c813cba24e6bb358cde67db683ec
Autor:
Alon Ben David, Yoel Papir, Ophir Hazan, Moses Redelman, Eran Diamant, Ada Barnea, Amram Torgeman, Ran Zichel
Publikováno v:
Toxins, Vol 14, Iss 4, p 281 (2022)
The receptor-binding domain of botulinum neurotoxin (HC fragment), is a promising botulism vaccine candidate. In the current study, fermentation strategies were evaluated to upscale HC fragment expression. A simple translation of the growth condition
Externí odkaz:
https://doaj.org/article/dc086b2aa5674e21b19844c7101e7d1c
Autor:
Adva Mechaly, Eran Diamant, Ron Alcalay, Alon Ben David, Eyal Dor, Amram Torgeman, Ada Barnea, Meni Girshengorn, Lilach Levin, Eyal Epstein, Ariel Tennenhouse, Sarel J. Fleishman, Ran Zichel, Ohad Mazor
Publikováno v:
Antibodies, Vol 11, Iss 1, p 21 (2022)
Botulinum neurotoxin type E (BoNT/E), the fastest acting toxin of all BoNTs, cleaves the 25 kDa synaptosomal-associated protein (SNAP-25) in motor neurons, leading to flaccid paralysis. The specific detection and quantification of the BoNT/E-cleaved
Externí odkaz:
https://doaj.org/article/797ceaec67d04932a171fe9845595a57
Autor:
Amram Torgeman, Eran Diamant, Eyal Dor, Arieh Schwartz, Tzadok Baruchi, Alon Ben David, Ran Zichel
Publikováno v:
Toxins, Vol 13, Iss 10, p 679 (2021)
Antitoxin, the only licensed drug therapy for botulism, neutralizes circulating botulinum neurotoxin (BoNT). However, antitoxin is no longer effective when a critical amount of BoNT has already entered its target nerve cells. The outcome is a chronic
Externí odkaz:
https://doaj.org/article/1b12d34b698546479985911a5bf24792
Autor:
Alon Ben David, Eran Diamant, Eyal Dor, Ada Barnea, Niva Natan, Lilach Levin, Shira Chapman, Lilach Cherry Mimran, Eyal Epstein, Ran Zichel, Amram Torgeman
Publikováno v:
Molecules, Vol 26, Iss 11, p 3213 (2021)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the coronavirus disease 2019 (COVID-19) global pandemic. The first step of viral infection is cell attachment, which is mediated by the binding of the SARS-CoV-2 receptor
Externí odkaz:
https://doaj.org/article/8be24612138f44aea3e3df4678089854
Autor:
Amram Torgeman, Arieh Schwartz, Eran Diamant, Tzadok Baruchi, Eyal Dor, Alon Ben David, Avi Pass, Ada Barnea, Arnon Tal, Amir Rosner, Osnat Rosen, Ran Zichel
Publikováno v:
Disease Models & Mechanisms, Vol 11, Iss 9 (2018)
Botulinum neurotoxin (BoNT) serotypes A, B and E are responsible for most cases of human botulism. The only approved therapy for botulism is antitoxin treatment administered to patients after symptom onset. However, a recent meta-analysis of antitoxi
Externí odkaz:
https://doaj.org/article/05ac6fb9ce8b420388c25b0c85055793
Publikováno v:
Toxins, Vol 7, Iss 6, Pp 1854-1881 (2015)
Monoclonal antibodies (MAbs) are among the fastest-growing therapeutics and are being developed for a broad range of indications, including the neutralization of toxins, bacteria and viruses. Nevertheless, MAbs potency is still relatively low when co
Externí odkaz:
https://doaj.org/article/73386d7fe3964f3c9e2ae235044896b1
Autor:
Amram Torgeman, Eyal Ozeri, Alon Ben David, Eran Diamant, Osnat Rosen, Arieh Schwartz, Ada Barnea, Arik Makovitzki, Avishai Mimran, Ran Zichel
Publikováno v:
Toxins, Vol 9, Iss 6, p 180 (2017)
The only approved treatment for botulism relies on passive immunity which is mostly based on antibody preparations collected from hyper‐immune horses. The IgG Fc fragment is commonly removed from these heterologous preparations to reduce the incide
Externí odkaz:
https://doaj.org/article/8fa85a5d204d434fa2620f990334a0cb
Autor:
Ron Alcalay, Meni Girshengorn, Eyal Epstein, Eran Diamant, Lilach Levin, Amram Torgeman, Ada Barnea, Ran Zichel, Eyal Dor, Alon Ben-David, Ariel Tennenhouse, Ohad Mazor, Sarel J. Fleishman, Adva Mechaly
Botulinum neurotoxin type E (BoNT/E), the fastest acting toxin of all BoNTs, cleaves the 25 kDa synaptosomal associated protein (SNAP-25) in motor neurons, leading to flaccid paralysis. Specific detection and quantification of BoNT/E-cleaved SNAP-25
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9215fb93236a0d82eecb0fcdff5cd139
https://doi.org/10.1101/2021.09.16.460610
https://doi.org/10.1101/2021.09.16.460610
