Výsledky vyhledávání - "Amr M. El Zawily"

Akademický článek

Glycosylation States of Pre- and Post-synaptic Markers of 5-HT Neurons Differ With Sex and 5-HTTLPR Genotype in Cortical Autopsy Samples

Autor: Jennifer N. K. Nyarko, Maa O. Quartey, Ryan M. Heistad, Paul R. Pennington, Lisa J. Poon, Kaeli J. Knudsen, Odette Allonby, Amr M. El Zawily, Andrew Freywald, Gail Rauw, Glen B. Baker, Darrell D. Mousseau

Publikováno v: Frontiers in Neuroscience, Vol 12 (2018)

The serotonin (5-hydroxytryptamine, 5-HT) transporter (5-HTT) gene-linked polymorphic region (5-HTTLPR) is thought to alter 5-HT signaling and contribute to behavioral and cognitive phenotypes in depression as well as Alzheimer disease (AD). We explo

Externí odkaz: https://doaj.org/article/37dcd3783e7d4a3f8dae0f7bd80ea29f

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Akademický článek

The Mitochondrial Metallochaperone SCO1 Is Required to Sustain Expression of the High-Affinity Copper Transporter CTR1 and Preserve Copper Homeostasis

Autor: Christopher J. Hlynialuk, Binbing Ling, Zakery N. Baker, Paul A. Cobine, Lisa D. Yu, Aren Boulet, Timothy Wai, Amzad Hossain, Amr M. El Zawily, Pamela J. McFie, Scot J. Stone, Francisca Diaz, Carlos T. Moraes, Deepa Viswanathan, Michael J. Petris, Scot C. Leary

Publikováno v: Cell Reports, Vol 10, Iss 6, Pp 933-943 (2015)

Human SCO1 fulfills essential roles in cytochrome c oxidase (COX) assembly and the regulation of copper (Cu) homeostasis, yet it remains unclear why pathogenic mutations in this gene cause such clinically heterogeneous forms of disease. Here, we esta

Externí odkaz: https://doaj.org/article/0340b7e99d004b629b58872104cbc6a2

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The EphB6 receptor is overexpressed in pediatric T cell acute lymphoblastic leukemia and increases its sensitivity to doxorubicin treatment

Autor: Frederick S. Vizeacoumar, Behzad M. Toosi, Andrew Freywald, Emily J McEwen, Franco J. Vizeacoumar, Amr M. El Zawily, Tanya Freywald

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Scientific Reports

While impressive improvements have been achieved in T-ALL therapy, current treatment approaches fail in approximately 25% of patients and these patients have limited treatment options. Another significant group of patients is being overtreated, which

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec2366ff574c3c9950f9dbcaa861ff24
http://link.springer.com/article/10.1038/s41598-017-15200-3

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The mitochondrial metallochaperone SCO1 maintains CTR1 at the plasma membrane to preserve copper homeostasis in the murine heart

Autor: Aren Boulet, Byung-Eun Kim, Zakery N. Baker, Glen F. Tibbits, Kimberly A. Jett, Amr M. El Zawily, Ling Lee, Paul A. Cobine, Scot C. Leary, Amzad Hossain, Michael J. Petris

Publikováno v: Human Molecular Genetics

SCO1 is a ubiquitously expressed, mitochondrial protein with essential roles in cytochrome c oxidase (COX) assembly and the regulation of copper homeostasis. SCO1 patients present with severe forms of early onset disease, and ultimately succumb from

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc7903af6f9b26dea3d83c4678d69449
https://doi.org/10.1093/hmg/ddx344

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The intrinsically kinase-inactive EPHB6 receptor predisposes cancer cells to DR5-induced apoptosis by promoting mitochondrial fragmentation

Autor: Vijaya Indukuri, Amr M. El Zawily, Andrew Freywald, Franco J. Vizeacoumar, Behzad M. Toosi, Scot C. Leary, Tanya Freywald

Publikováno v: Oncotarget

// Amr M. El Zawily 1, 2 , Behzad M. Toosi 1 , Tanya Freywald 3 , Vijaya V. Indukuri 4 , Franco J. Vizeacoumar 1, 3 , Scot C. Leary 4 , Andrew Freywald 1 1 Department of Pathology and Laboratory Medicine, College of Medicine, University of Saskatchew

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08199ba85814eb443ed1f727cacfc10f
https://doi.org/10.18632/oncotarget.12838

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Targeting synthetic lethality between the SRC kinase and the EPHB6 receptor may benefit cancer treatment

Autor: Yue Li, Courtney Gerger, Behzad M. Toosi, Frederick S. Vizeacoumar, Rani Kanthan, Amr M. El Zawily, Darrell D. Mousseau, Kalpana Kalyanasundaram Bhanumathy, James M. Paul, Tanya Freywald, Deborah H. Anderson, Franco J. Vizeacoumar, Zhaolei Zhang, Andrew Freywald

Publikováno v: Oncotarget

// James M. Paul 1, * , Behzad Toosi 2, * , Frederick S. Vizeacoumar 2, * , Kalpana Kalyanasundaram Bhanumathy 2 , Yue Li 3, 4, 5 , Courtney Gerger 2 , Amr El Zawily 2, 6 , Tanya Freywald 7 , Deborah H. Anderson 7 , Darrell Mousseau 8 , Rani Kanthan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c4bcacbec8fe51f77b5a11126e8a7ee
http://europepmc.org/articles/PMC5226566

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Glycosylation States of Pre- and Post-synaptic Markers of 5-HT Neurons Differ With Sex and 5-HTTLPR Genotype in Cortical Autopsy Samples

Autor: Gail Rauw, Lisa J Poon, Odette Allonby, Darrell D. Mousseau, Maa O. Quartey, Ryan M. Heistad, Amr M. El Zawily, Glen B. Baker, Andrew Freywald, Kaeli J. Knudsen, Jennifer N. K. Nyarko, Paul R. Pennington

Publikováno v: Frontiers in Neuroscience, Vol 12 (2018)
Frontiers in Neuroscience

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78fa94c2a130bc9dca1c40e0c07817d3
https://www.frontiersin.org/article/10.3389/fnins.2018.00545/full

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The Mitochondrial Metallochaperone SCO1 Is Required to Sustain Expression of the High-Affinity Copper Transporter CTR1 and Preserve Copper Homeostasis

Autor: Scot C. Leary, Francisca Diaz, Michael J. Petris, Chris Hlynialuk, Timothy Wai, Amr M. El Zawily, Paul A. Cobine, S. Stone, Amzad Hossain, Pamela J. McFie, Lisa D. Yu, Deepa Viswanathan, Aren Boulet, Binbing Ling, Carlos T. Moraes, Zakery N. Baker

Publikováno v: Cell Reports
Cell Reports, Elsevier Inc, 2015, 10 (6), pp.933-943. ⟨10.1016/j.celrep.2015.01.019⟩
Cell Reports, Vol 10, Iss 6, Pp 933-943 (2015)

Summary Human SCO1 fulfills essential roles in cytochrome c oxidase (COX) assembly and the regulation of copper (Cu) homeostasis, yet it remains unclear why pathogenic mutations in this gene cause such clinically heterogeneous forms of disease. Here,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ce67bbaae583bfa15162eb09dee343c
https://doi.org/10.1016/j.celrep.2015.01.019

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Ligand stimulation induces clathrin- and Rab5-dependent downregulation of the kinase-dead EphB6 receptor preceded by the disruption of EphB6-Hsp90 interaction

Autor: Andrew Freywald, Jennifer Chlan, John F. DeCoteau, Mohan Babu, Tanya Freywald, Darrell D. Mousseau, Deborah H. Anderson, Odette Allonby, Vishaldeep Sidhu, Amr M. El Zawily, Alexandre Benmerah

Publikováno v: Cellular Signalling. 26:2645-2657

Ligand-induced internalisation and subsequent downregulation of receptor tyrosine kinases (RTKs) serve to determine biological outputs of their signalling. Intrinsically kinase-deficient RTKs control a variety of biological responses, however, the me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3d340146153d793d23f87ba5c75ae2f
https://doi.org/10.1016/j.cellsig.2014.08.007

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