Zobrazeno 1 - 10
of 84
pro vyhledávání: '"Amr M Ghaleb"'
Autor:
Amr M Ghaleb, Agnieszka B Bialkowska, Ashley J Snider, Dmitri V Gnatenko, Yusuf A Hannun, Vincent W Yang, Valentina A Schmidt
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0129314 (2015)
IQ motif-containing GTPase-activating protein 2 (IQGAP2) is a multidomain scaffolding protein that plays a role in cytoskeleton regulation by juxtaposing Rho GTPase and Ca2+/calmodulin signals. While IQGAP2 suppresses tumorigenesis in liver, its role
Externí odkaz:
https://doaj.org/article/e1e963824a714414990feb147a2811a1
Autor:
Ashley J Snider, Wahida H Ali, Jonathan A Sticca, Nicolas Coant, Amr M Ghaleb, Toshihiko Kawamori, Vincent W Yang, Yusuf A Hannun, Lina M Obeid
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e113998 (2014)
Sphingosine kinase 1 (SK1), one of two SK enzymes, is highly regulated and has been shown to act as a focal point for the action of many growth factors and cytokines. SK1 leads to generation of sphingosine-1-phosphate (S1P) and potentially the activa
Externí odkaz:
https://doaj.org/article/ee8575fa4dc74a55a293c690bc7704c7
Supplementary Figure Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b8f2a9b56f5dab23c93c886e3271409e
https://doi.org/10.1158/1541-7786.22515156.v1
https://doi.org/10.1158/1541-7786.22515156.v1
Klf4ΔIS/ApcMin/+ mice have stronger beta-catenin, Ki67 and cyclin D1 staining in the small intestine than Klf4fl/fl/ApcMin/+ mice.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::337d6b7a9a80113967c62f28268cdf66
https://doi.org/10.1158/1541-7786.22515165
https://doi.org/10.1158/1541-7786.22515165
Beta-catenin, Ki67 and cyclin D1 staining in colonic adenomas of Klf4fl/fl/ApcMin/+ and Klf4ΔIS/ApcMin/+ mice.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6606f9cd0909974dc5c94114fb140339
https://doi.org/10.1158/1541-7786.22515162.v1
https://doi.org/10.1158/1541-7786.22515162.v1
Klf4ΔIS/ApcMin/+ mice develop significantly more small intestinal adenomas than Klf4fl/fl/ApcMin/+ mice.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19d956ccc5406676f93eb459a69c20cc
https://doi.org/10.1158/1541-7786.22515168
https://doi.org/10.1158/1541-7786.22515168
Klf4ΔIS mice develop micro adenomas at an earlier time point (8 weeks) following AOM treatment.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10a7d3122198f80d11d9e95c6a3e3053
https://doi.org/10.1158/1541-7786.22515159.v1
https://doi.org/10.1158/1541-7786.22515159.v1
The zinc finger-containing transcription factor, Krüppel-like factor 4 (KLF4), inhibits cell proliferation. An in vivo tumor-suppressive role for KLF4 is shown by the recent finding that Klf4 haploinsufficiency in ApcMin/+ mice promotes intestinal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::785c72160b3192fb712775f2f96514bd
https://doi.org/10.1158/1541-7786.c.6541801
https://doi.org/10.1158/1541-7786.c.6541801
Supplementary Figures S1-S8 from Notch Inhibits Expression of the Krüppel-Like Factor 4 Tumor Suppressor in the Intestinal Epithelium
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77a1160712c45d2e437bce4b54709d36
https://doi.org/10.1158/1541-7786.22517692
https://doi.org/10.1158/1541-7786.22517692
Autor:
Vincent W. Yang, Klaus H. Kaestner, Jonathan P. Katz, Mandayam O. Nandan, Beth B. McConnell, Amr M. Ghaleb
Supplementary Figure 3 from Haploinsufficiency of Krüppel-Like Factor 4 Promotes Adenomatous Polyposis Coli–Dependent Intestinal Tumorigenesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a8e4a30e2f27bf55accffcdfb80ff8a
https://doi.org/10.1158/0008-5472.22367760.v1
https://doi.org/10.1158/0008-5472.22367760.v1