Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Amr H. Wardeh"'
Autor:
Viktoria Gusarova, Colm O’Dushlaine, Tanya M. Teslovich, Peter N. Benotti, Tooraj Mirshahi, Omri Gottesman, Cristopher V. Van Hout, Michael F. Murray, Anubha Mahajan, Jonas B. Nielsen, Lars Fritsche, Anders Berg Wulff, Daniel F. Gudbjartsson, Marketa Sjögren, Connor A. Emdin, Robert A. Scott, Wen-Jane Lee, Aeron Small, Lydia C. Kwee, Om Prakash Dwivedi, Rashmi B. Prasad, Shannon Bruse, Alexander E. Lopez, John Penn, Anthony Marcketta, Joseph B. Leader, Christopher D. Still, H. Lester Kirchner, Uyenlinh L. Mirshahi, Amr H. Wardeh, Cassandra M. Hartle, Lukas Habegger, Samantha N. Fetterolf, Teresa Tusie-Luna, Andrew P. Morris, Hilma Holm, Valgerdur Steinthorsdottir, Patrick Sulem, Unnur Thorsteinsdottir, Jerome I. Rotter, Lee-Ming Chuang, Scott Damrauer, David Birtwell, Chad M. Brummett, Amit V. Khera, Pradeep Natarajan, Marju Orho-Melander, Jason Flannick, Luca A. Lotta, Cristen J. Willer, Oddgeir L. Holmen, Marylyn D. Ritchie, David H. Ledbetter, Andrew J. Murphy, Ingrid B. Borecki, Jeffrey G. Reid, John D. Overton, Ola Hansson, Leif Groop, Svati H. Shah, William E. Kraus, Daniel J. Rader, Yii-Der I. Chen, Kristian Hveem, Nicholas J. Wareham, Sekar Kathiresan, Olle Melander, Kari Stefansson, Børge G. Nordestgaard, Anne Tybjærg-Hansen, Goncalo R. Abecasis, David Altshuler, Jose C. Florez, Michael Boehnke, Mark I. McCarthy, George D. Yancopoulos, David J. Carey, Alan R. Shuldiner, Aris Baras, Frederick E. Dewey, Jesper Gromada
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Genetic variation in ANGPTL4 is associated with lipid traits. Here, the authors find that predicted loss-of-function variants in ANGPTL4 are associated with glucose homeostasis and reduced risk of type 2 diabetes and that Angptl4 −/− mice on a hi
Externí odkaz:
https://doaj.org/article/a3d832a109514250b3a42f9eaa1a1b95
Autor:
Anatoliy Vaysberg, Prateek Prasanna, Vadim Spektor, Amr H. Wardeh, Niha Beig, Nicole M Sakla, Gagandeep Singh, Sunil Manjila, John Matthews, Alan True
Publikováno v:
British Journal of Cancer
The natural history and treatment landscape of primary brain tumours are complicated by the varied tumour behaviour of primary or secondary gliomas (high-grade transformation of low-grade lesions), as well as the dilemmas with identification of radia
Autor:
Teresa Tusié-Luna, Svati H. Shah, Wen-Jane Lee, Amit Khera, Gonçalo R. Abecasis, Olle Melander, Alan R. Shuldiner, Connor A. Emdin, Kari Stefansson, Jesper Gromada, Andrew P. Morris, Lee-Ming Chuang, Omri Gottesman, Lars G. Fritsche, Pradeep Natarajan, Marju Orho-Melander, Daniel F. Gudbjartsson, Anubha Mahajan, Marylyn D. Ritchie, William E. Kraus, Tooraj Mirshahi, Colm O'Dushlaine, Jason Flannick, Nicholas J. Wareham, Anne Tybjærg-Hansen, Anders Berg Wulff, Rashmi B. Prasad, Aris Baras, Jonas B. Nielsen, Valgerdur Steinthorsdottir, Yii-Der Ida Chen, Jerome I. Rotter, Lukas Habegger, Samantha N. Fetterolf, David Altshuler, Om Prakash Dwivedi, Tanya M. Teslovich, Cristen J. Willer, Luca A. Lotta, Andrew J. Murphy, Joseph B. Leader, Cristopher V. Van Hout, Christopher D. Still, Ola Hansson, David Birtwell, Alexander Lopez, Daniel J. Rader, John D. Overton, Anthony Marcketta, Patrick Sulem, Peter N. Benotti, Jose C. Florez, Lydia Coulter Kwee, David J. Carey, Oddgeir L. Holmen, Kristian Hveem, Leif Groop, Sekar Kathiresan, Viktoria Gusarova, Unnur Thorsteinsdottir, Cassandra M. Hartle, Uyenlinh L. Mirshahi, H. Lester Kirchner, Shannon Bruse, Robert A. Scott, Michael F. Murray, Marketa Sjögren, Jeffrey G. Reid, Aeron Small, Børge G. Nordestgaard, Amr H. Wardeh, Chad M. Brummett, Mark I. McCarthy, Frederick E. Dewey, David H. Ledbetter, John Penn, Ingrid B. Borecki, Scott M. Damrauer, Hilma Holm, Michael Boehnke, George D. Yancopoulos
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Gusarova, V, O'Dushlaine, C, Teslovich, T M, Benotti, P N, Mirshahi, T, Gottesman, O, Van Hout, C V, Murray, M F, Mahajan, A, Nielsen, J B, Fritsche, L, Wulff, A B, Gudbjartsson, D F, Sjögren, M, Emdin, C A, Scott, R A, Lee, W-J, Small, A, Kwee, L C, Dwivedi, O P, Prasad, R B, Bruse, S, Lopez, A E, Penn, J, Marcketta, A, Leader, J B, Still, C D, Kirchner, H L, Mirshahi, U L, Wardeh, A H, Hartle, C M, Habegger, L, Fetterolf, S N, Tusie-Luna, T, Morris, A P, Holm, H, Steinthorsdottir, V, Sulem, P, Thorsteinsdottir, U, Rotter, J I, Chuang, L-M, Damrauer, S, Birtwell, D, Brummett, C M, Khera, A V, Natarajan, P, Orho-Melander, M, Flannick, J, Lotta, L A, Willer, C J, Holmen, O L, Ritchie, M D, Ledbetter, D H, Murphy, A J, Borecki, I B, Reid, J G, Overton, J D, Hansson, O, Groop, L, Shah, S H, Kraus, W E, Rader, D J, Chen, Y-D I, Hveem, K, Wareham, N J, Kathiresan, S, Melander, O, Stefansson, K, Nordestgaard, B G, Tybjærg-Hansen, A, Abecasis, G R, Altshuler, D, Florez, J C, Boehnke, M, McCarthy, M I, Yancopoulos, G D, Carey, D J, Shuldiner, A R, Baras, A, Dewey, F E & Gromada, J 2018, ' Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes ', Nature Communications, vol. 9, no. 1, pp. 2252 . https://doi.org/10.1038/s41467-018-04611-z
Gusarova, V, O'Dushlaine, C, Teslovich, T M, Benotti, P N, Mirshahi, T, Gottesman, O, Van Hout, C V, Murray, M F, Mahajan, A, Nielsen, J B, Fritsche, L, Wulff, A B, Gudbjartsson, D F, Sjögren, M, Emdin, C A, Scott, R A, Lee, W J, Small, A, Kwee, L C, Dwivedi, O P, Prasad, R B, Bruse, S, Lopez, A E, Penn, J, Marcketta, A, Leader, J B, Still, C D, Kirchner, H L, Mirshahi, U L, Wardeh, A H, Hartle, C M, Habegger, L, Fetterolf, S N, Tusie-Luna, T, Morris, A P, Holm, H, Steinthorsdottir, V, Sulem, P, Thorsteinsdottir, U, Rotter, J I, Chuang, L M, Damrauer, S, Birtwell, D, Brummett, C M, Khera, A V, Natarajan, P, Orho-Melander, M, Flannick, J, Lotta, L A, Willer, C J, Holmen, O L, Ritchie, M D, Ledbetter, D H, Murphy, A J, Borecki, I B, Reid, J G, Overton, J D, Hansson, O, Groop, L, Shah, S H, Kraus, W E, Rader, D J, Chen, Y D I, Hveem, K, Wareham, N J, Kathiresan, S, Melander, O, Stefansson, K, Nordestgaard, B G, Tybjærg-Hansen, A, Abecasis, G R, Altshuler, D, Florez, J C, Boehnke, M, McCarthy, M I, Yancopoulos, G D, Carey, D J, Shuldiner, A R, Baras, A, Dewey, F E & Gromada, J 2018, ' Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes ', Nature Communications, vol. 9, no. 1, 2252 . https://doi.org/10.1038/s41467-018-04611-z
Nature Communications
Nature communications, vol 9, iss 1
Gusarova, V, O'Dushlaine, C, Teslovich, T M, Benotti, P N, Mirshahi, T, Gottesman, O, Van Hout, C V, Murray, M F, Mahajan, A, Nielsen, J B, Fritsche, L, Wulff, A B, Gudbjartsson, D F, Sjögren, M, Emdin, C A, Scott, R A, Lee, W-J, Small, A, Kwee, L C, Dwivedi, O P, Prasad, R B, Bruse, S, Lopez, A E, Penn, J, Marcketta, A, Leader, J B, Still, C D, Kirchner, H L, Mirshahi, U L, Wardeh, A H, Hartle, C M, Habegger, L, Fetterolf, S N, Tusie-Luna, T, Morris, A P, Holm, H, Steinthorsdottir, V, Sulem, P, Thorsteinsdottir, U, Rotter, J I, Chuang, L-M, Damrauer, S, Birtwell, D, Brummett, C M, Khera, A V, Natarajan, P, Orho-Melander, M, Flannick, J, Lotta, L A, Willer, C J, Holmen, O L, Ritchie, M D, Ledbetter, D H, Murphy, A J, Borecki, I B, Reid, J G, Overton, J D, Hansson, O, Groop, L, Shah, S H, Kraus, W E, Rader, D J, Chen, Y-D I, Hveem, K, Wareham, N J, Kathiresan, S, Melander, O, Stefansson, K, Nordestgaard, B G, Tybjærg-Hansen, A, Abecasis, G R, Altshuler, D, Florez, J C, Boehnke, M, McCarthy, M I, Yancopoulos, G D, Carey, D J, Shuldiner, A R, Baras, A, Dewey, F E & Gromada, J 2018, ' Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes ', Nature Communications, vol. 9, no. 1, pp. 2252 . https://doi.org/10.1038/s41467-018-04611-z
Gusarova, V, O'Dushlaine, C, Teslovich, T M, Benotti, P N, Mirshahi, T, Gottesman, O, Van Hout, C V, Murray, M F, Mahajan, A, Nielsen, J B, Fritsche, L, Wulff, A B, Gudbjartsson, D F, Sjögren, M, Emdin, C A, Scott, R A, Lee, W J, Small, A, Kwee, L C, Dwivedi, O P, Prasad, R B, Bruse, S, Lopez, A E, Penn, J, Marcketta, A, Leader, J B, Still, C D, Kirchner, H L, Mirshahi, U L, Wardeh, A H, Hartle, C M, Habegger, L, Fetterolf, S N, Tusie-Luna, T, Morris, A P, Holm, H, Steinthorsdottir, V, Sulem, P, Thorsteinsdottir, U, Rotter, J I, Chuang, L M, Damrauer, S, Birtwell, D, Brummett, C M, Khera, A V, Natarajan, P, Orho-Melander, M, Flannick, J, Lotta, L A, Willer, C J, Holmen, O L, Ritchie, M D, Ledbetter, D H, Murphy, A J, Borecki, I B, Reid, J G, Overton, J D, Hansson, O, Groop, L, Shah, S H, Kraus, W E, Rader, D J, Chen, Y D I, Hveem, K, Wareham, N J, Kathiresan, S, Melander, O, Stefansson, K, Nordestgaard, B G, Tybjærg-Hansen, A, Abecasis, G R, Altshuler, D, Florez, J C, Boehnke, M, McCarthy, M I, Yancopoulos, G D, Carey, D J, Shuldiner, A R, Baras, A, Dewey, F E & Gromada, J 2018, ' Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes ', Nature Communications, vol. 9, no. 1, 2252 . https://doi.org/10.1038/s41467-018-04611-z
Nature Communications
Nature communications, vol 9, iss 1
Angiopoietin-like 4 (ANGPTL4) is an endogenous inhibitor of lipoprotein lipase that modulates lipid levels, coronary atherosclerosis risk, and nutrient partitioning. We hypothesize that loss of ANGPTL4 function might improve glucose homeostasis and d
Autor:
Amr H. Wardeh, Ying S. Hu, Catarina B. Manney, Alan R. Shuldiner, Joseph B. Leader, Janet L. Williams, David J. Carey, Toni I. Pollin, Jeffrey Staples, Jessica M. Goehringer, Uyenlinh L. Mirshahi
Publikováno v:
Diabetes. 68
Maturity onset diabetes of the young (MODY) is a monogenic form of diabetes attributed to a highly penetrant variant in one of several genes, including GCK. GCK-MODY rarely requires pharmacotherapy, however, the clinical management of pregnant mother
Autor:
Kandamurugu Manickam, Uyenlinh L. Mirshahi, Jonathan Z. Luo, Tooraj Mirshahi, Amr H. Wardeh, David J. Carey, Michael F. Murray
Publikováno v:
Genetics in medicine : official journal of the American College of Medical Genetics. 21(6)
Precision health initiatives and reduced sequencing costs are driving large-scale human genome analyses. Genetic variant curation is a bottleneck in clinical applications. The burden of variant curation can be high for newly discovered variants becau
Autor:
Rong Chen, Uyenlinh L. Mirshahi, David J. Carey, Shuyu Li, Michael F. Murray, Ke Hao, Kristin L. Ayers, Amr H. Wardeh, Benjamin S. Glicksberg
Publikováno v:
BMC Genomics
Background Alzheimer’s disease (AD) represents the most common form of dementia in elder populations with approximately 30 million cases worldwide. Genome wide genotyping and sequencing studies have identified many genetic variants associated with
Autor:
Ingrid B. Borecki, Frederick E. Dewey, Dustin N. Hartzel, D’Andra M. Lindbuchler, H. Lester Kirchner, Marci L Barr, Joseph B. Leader, David H. Ledbetter, Aris Baras, Omri Gottesman, Eric A. Wright, Michael F. Murray, David J. Carey, Amr H. Wardeh, Jeffrey G. Reid, Alan R. Shuldiner, Claudia Gonzaga-Jauregui, Noura S. Abul-Husn, Laney K. Jones, John D. Overton, Raghu Metpally, Monica A. Giovanni, Marylyn D. Ritchie, Colm O'Dushlaine, Kandamurugu Manickam, George D. Yancopoulos
Publikováno v:
Science (New York, N.Y.). 354(6319)
Unleashing the power of precision medicine Precision medicine promises the ability to identify risks and treat patients on the basis of pathogenic genetic variation. Two studies combined exome sequencing results for over 50,000 people with their elec
Autor:
Jaya Prakash Sugunaraj, Uyenlinh L. Mirshahi, David J. Carey, Michael F. Murray, Jason Stamm, Catarina B. Manney, Kandamurugu Manickam, Amr H. Wardeh
Publikováno v:
Chest. 150:1132A