Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Amr H. Allam"'
Autor:
Anne Huber, Amr H. Allam, Christine Dijkstra, Stefan Thiem, Jennifer Huynh, Ashleigh R. Poh, Joshua Konecnik, Saumya P. Jacob, Rita Busuttil, Yang Liao, David Chisanga, Wei Shi, Mariah G. Alorro, Stephen Forrow, Daniele V.F. Tauriello, Eduard Batlle, Alex Boussioutas, David S. Williams, Michael Buchert, Matthias Ernst, Moritz F. Eissmann
Publikováno v:
Cell Reports, Vol 43, Iss 8, Pp 114616- (2024)
Summary: Although aberrant activation of the KRAS and PI3K pathway alongside TP53 mutations account for frequent aberrations in human gastric cancers, neither the sequence nor the individual contributions of these mutations have been clarified. Here,
Externí odkaz:
https://doaj.org/article/bcbb4c19d532433d8228119f5febdeda
Autor:
Amr H. Allam, Sarah M. Russell
Publikováno v:
STAR Protocols, Vol 3, Iss 3, Pp 101472- (2022)
Summary: Multiplexed immunohistochemistry enables analysis of cellular and signaling events in the context of an intact organ. Here, we describe protocols for applying multiplexed immunohistochemistry to the mouse thymus. In particular, we describe h
Externí odkaz:
https://doaj.org/article/340094d1dd014076974bd98f5b0d2b08
Autor:
Riley J. Morrow, Amr H. Allam, Josh Konecnik, David Baloyan, Christine Dijkstra, Moritz F. Eissmann, Saumya P. Jacob, Megan O’Brien, Ashleigh R. Poh, Matthias Ernst
Publikováno v:
Cells, Vol 11, Iss 24, p 4104 (2022)
Aberrant expression of the oncoprotein c-Myc (Myc) is frequently observed in solid tumors and is associated with reduced overall survival. In addition to well-recognized cancer cell-intrinsic roles of Myc, studies have also suggested tumor-promoting
Externí odkaz:
https://doaj.org/article/e07f1bdc3de4487b93a8929e1842ee67
A critical stage of T cell development is β-selection; at this stage, the T cell receptor β (TCRβ) chain is generated, and the developing T cell starts to acquire antigenic specificity. Progression through β-selection is assisted by low-affinity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5348f471d8bcc631fc77ec5fe52efd14
Autor:
Riley J. Morrow, Amr H. Allam, Belinda Yeo, Siddhartha Deb, Carmel Murone, Elgene Lim, Cameron N. Johnstone, Matthias Ernst
Publikováno v:
Cancers; Volume 14; Issue 9; Pages: 2292
Inflammatory breast cancer (IBC) describes a highly aggressive form of breast cancer of diverse molecular subtypes and clonal heterogeneity across individual tumors. Accordingly, IBC is recognized by its clinical signs of inflammation, associated wit
Publikováno v:
The Journal of Cell Biology
During T cell development, genomic rearrangement must create a T cell receptor capable of transmitting signals. Allam et al. show that passage through the β-selection checkpoint requires the assembly of a platform to support TCR signaling, similar t
The β-selection checkpoint of T cell development tests whether the cell has recombined its genomic DNA to produce a functional T Cell Receptor β (TCRβ) receptor. Passage through the β-selection checkpoint requires the nascent TCRβ protein to med
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1255c3e7d0e7aae453c27d934a7da20
Publikováno v:
Journal of molecular biology. 430(19)
Cell polarity is an essential process shared by almost all animal tissues. Moreover, cell polarity enables cells to sense and respond to the cues provided by the neighboring cells and the surrounding microenvironment. These responses play a critical
Autor:
Amr H. Allam, Maija R.J. Kohonen-Corish, Fahad Benthani, Paul Timpson, Nicola Currey, Sam Al-Sohaily, T. Phuong, Janindra Warusavitarne, Morghan C. Lucas, David Herrmann
Publikováno v:
ESMO Open. 3:A86-A87
Introduction The ‘Mutated in colorectal cancer’ (MCC) gene was originally discovered due to its linkage with the APC gene. MCC is silenced through gene promoter methylation in colorectal cancer (CRC) but its significance has been poorly understoo
Autor:
Laurent Pangon, Amr H. Allam, Paul Timpson, F A Benthani, Janindra Warusavitarne, David Herrmann, Morghan C. Lucas, Phuong N. Tran, Nicola Currey, Sam Al-Sohaily, Maija R.J. Kohonen-Corish, Marc Giry-Laterriere
Publikováno v:
Oncogene. 37(5)
E-cadherin and β-catenin are key proteins that are essential in the formation of the epithelial cell layer in the colon but their regulatory pathways that are disrupted in cancer metastasis are not completely understood. Mutated in colorectal cancer