Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Amr Ellaithy"'
Autor:
Amr Ellaithy, Nandakumar S. Narayanan
Publikováno v:
Neurology
From Alexander Fleming's discovery of penicillin in 1928 to the recent awarding of the 2018 Nobel Prize in Medicine and Physiology to Tasuku Honjo for his work with James Allison on immune checkpoints, physician-scientists have made and continue to m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6d8f0be316e8a197ee9e0510b862fda
https://europepmc.org/articles/PMC6598794/
https://europepmc.org/articles/PMC6598794/
Autor:
Kelsey S. Hideshima, Diomedes E. Logothetis, Jose M. Eltit, Jason Younkin, Lia Baki, Amr Ellaithy, Supriya A Gaitonde, Javier González-Maeso, Malgorzata Dukat, José L. Moreno, Rakesh H. Vekariya, Sneha Shah, Richard A. Glennon, Peter Drossopoulos
Publikováno v:
ACS Chemical Neuroscience. 7:1292-1299
Several pharmacophore models have been proposed for 5-HT2A serotonin receptor antagonists. These typically consist of two aromatic/hydrophobic moieties separated by a given distance from each other, and from a basic amine. Although specified distance
Autor:
Hailin Zhang, Jason Younkin, Guoqing Xiang, George Liapakis, Katerina Spyridaki, Meng Cui, Miguel Fribourg, Amr Ellaithy, Candice Hatcher-Solis, Javier González-Maeso, Diomedes E. Logothetis
Publikováno v:
Current Pharmaceutical Biotechnology. 15:987-995
Kir3 (or GIRK) channels have been known for nearly three decades to be activated by direct interactions with the βγ subunits of heterotrimeric G (Gαβγ) proteins in a membrane-delimited manner. Gα also interacts with GIRK channels and since PTX-
Autor:
Balatsoukas Agisilaos, Takeharu Kawano, Meng Cui, Guoqing Xiang, Manolakou Danai, Amr Ellaithy, Yu Xu, Diomedes E. Logothetis
Publikováno v:
Biophysical Journal. 110(3)
Background: Metabotropic glutamate type 2 receptor (mGlu2R) is a Class C G-protein coupled receptor (GPCR), widely distributed in the brain where it mainly functions to limit excess glutamate release. mGlu2R positive allosteric modulators (PAMs) prov
Publikováno v:
Trends in neurosciences. 38(8)
The past two decades have witnessed a rise in the ‘NMDA receptor hypofunction’ hypothesis for schizophrenia, a devastating disorder that affects around 1% of the population worldwide. A variety of presynaptic, postsynaptic, and regulatory protein
Publikováno v:
Biophysical Journal. 112:530a
Autor:
Mohamed El-Gamal, Basem Helmy, Mie A. Mohamed, Amr Ellaithy, Dina Tantawy, Mohamed A. Sobh, Mohamed Salama, Hussein Sheashaa, Amr Reda, Aya El-Gamal
Publikováno v:
Environmental toxicology and pharmacology. 35(2)
A key feature of Parkinson's disease is the dopaminergic neuronal cell loss in the substantia nigra pars compacta. Many triggering pathways have been incriminated in the pathogenesis of this disease including inflammation, oxidative stress, excitotox
Autor:
Mie A. Mohamed, Dina Tantawy, Oscar Arias-Carrión, Mohamed El-Gamal, Amr Ellaithy, Mohamed Salama, Hussein Sheashaa, Basem Helmy, Mohamed A. Sobh
Publikováno v:
CNSneurological disorders drug targets. 11(7)
A key feature of Parkinson’s disease is the dopaminergic neuronal cell loss in the substantia nigra pars compacta. Besides inflammation, oxidative stress and apoptosis, a recent hypothesis suggested that degeneration of dopaminergic neurons occurs
Autor:
Zhanna V. Vysotskaya, Miguel Fribourg, Gyu Park, Amr Ellaithy, Jason Younkin, Jose M. Eltit, Diomedes E. Logothetis, Lia Baki
Publikováno v:
Biophysical Journal. 108:416a
Atypical antipsychotic drugs targeting the 5-HT2A receptor (2AR) are widely used in the treatment of schizophrenia and psychosis. Recent studies point to a new class of potential antipsychotic drugs targeting the metabotropic glutamate receptor 2 (mG