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Akademický článek

Heterozygous knockout of Synaptotagmin13 phenocopies ALS features and TP53 activation in human motor neurons

Autor: Johannes Lehmann, Amr Aly, Christina Steffke, Luca Fabbio, Valentin Mayer, Natalie Dikwella, Kareen Halablab, Francesco Roselli, Simone Seiffert, Tobias M. Boeckers, David Brenner, Edor Kabashi, Medhanie Mulaw, Ritchie Ho, Alberto Catanese

Publikováno v: Cell Death and Disease, Vol 15, Iss 8, Pp 1-12 (2024)

Abstract Spinal motor neurons (MNs) represent a highly vulnerable cellular population, which is affected in fatal neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA). In this study, we show that th

Externí odkaz: https://doaj.org/article/7716fd763a5e4ff6b0567b3fb8f2622d

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Akademický článek

Narrow band endoscopic diagnosis of portal hypertensive gastropathy in cirrhotic patients

Autor: Randa Salah Eldin Abdelmoneim Ibrahim, Amr Aly Abdelmoety, Nahed Baddour, Perihan Salem, Marwa Metawea

Publikováno v: Alexandria Journal of Medicine, Vol 58, Iss 1, Pp 38-43 (2022)

Background Portal hypertensive gastropathy (PHG) is an overlooked complication of liver cirrhosis, as it is a source of acute upper gastrointestinal bleeding and cause of chronic blood loss.Objective To assess the role of narrow band endoscopy in the

Externí odkaz: https://doaj.org/article/1b0ac22a210a4cd0b8716bba6497d4fb

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Akademický článek

The classification of gastric antral vascular ectasia in cirrhotic patients by Versatile Intelligent Staining Technology

Autor: Randa Salah Eldin Abdelmoneim, Amr Aly Abdelmoety, Nahed Baddour, Perihan Salem, Marwa Metawea

Publikováno v: Egyptian Liver Journal, Vol 12, Iss 1, Pp 1-6 (2022)

Abstract Background Portal hypertensive gastropathy (PHG) and gastric antral vascular ectasia (GAVE) are two different pathologies that cause bleeding in cirrhotic patients. These two pathologies are still difficult to be distinguished by white light

Externí odkaz: https://doaj.org/article/cf9f911ebe0d4edc9870d73ff2741049

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Akademický článek

Synaptic disruption and CREB‐regulated transcription are restored by K+ channel blockers in ALS

Autor: Alberto Catanese, Sandeep Rajkumar, Daniel Sommer, Dennis Freisem, Alexander Wirth, Amr Aly, David Massa‐López, Andrea Olivieri, Federica Torelli, Valentin Ioannidis, Joanna Lipecka, Ida Chiara Guerrera, Daniel Zytnicki, Albert Ludolph, Edor Kabashi, Medhanie A Mulaw, Francesco Roselli, Tobias M Böckers

Publikováno v: EMBO Molecular Medicine, Vol 13, Iss 7, Pp 1-16 (2021)

Abstract Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease, which is still missing effective therapeutic strategies. Although manipulation of neuronal excitability has been tested in murine and human ALS models, it is still und

Externí odkaz: https://doaj.org/article/9f44870789f04f35b7c34f0133d28f07

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Akademický článek

Aging-Dependent Altered Transcriptional Programs Underlie Activity Impairments in Human C9orf72-Mutant Motor Neurons

Autor: Daniel Sommer, Sandeep Rajkumar, Mira Seidel, Amr Aly, Albert Ludolph, Ritchie Ho, Tobias M. Boeckers, Alberto Catanese

Publikováno v: Frontiers in Molecular Neuroscience, Vol 15 (2022)

Amyotrophic Lateral Sclerosis (ALS) is an incurable neurodegenerative disease characterized by dysfunction and loss of upper and lower motor neurons (MN). Despite several studies identifying drastic alterations affecting synaptic composition and func

Externí odkaz: https://doaj.org/article/bd190b2000864ddcbbde57f658f6cbe2

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Akademický článek

Imaging guided streptokinase injected through small bore pigtail tail catheter in management of complicated empyema in pediatrics

Autor: Sherif El-Sayed Mahmoud Hegab, Maged Mohamed El-Sayed Eissa, Amr Aly Aly Abdel-Kerim, Mohamed Said Abel Aziz

Publikováno v: The Egyptian Journal of Radiology and Nuclear Medicine, Vol 48, Iss 1, Pp 133-139 (2017)

Purpose: This study was done targeting the role of streptokinase injected through pigtail catheter in treatment of pleural empyema in pediatric. Subjects and methods: 15 patients were involved in this study of age ranged from 5 months to 15 years wer

Externí odkaz: https://doaj.org/article/26e7bf4e828b4d8db1c9bc75a905665c

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