Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Amr Al-Zain"'
Publikováno v:
bioRxiv
Inverted duplications, also known as foldback inversions, are commonly observed in cancers and are the major class of chromosome rearrangement recovered from yeast cells lacking Mre11 nuclease. Foldback priming at naturally occurring inverted repeats
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27efb2d23ef207837a0042c64a036064
https://doi.org/10.1101/2023.01.24.525421
https://doi.org/10.1101/2023.01.24.525421
Autor:
Weixing Zhao, Zhi Qi, Lorraine S. Symington, Ondrej Beláň, Eric C. Greene, Patrick Sung, Simon J. Boulton, Amr Al-Zain, Tsuyoshi Terakawa, Youngho Kwon, Rodney Rothstein, Justin B. Steinfeld, J. Brooks Crickard, Michael J. Smith
Publikováno v:
Genes & Development
The vast majority of eukaryotes possess two DNA recombinases: Rad51, which is ubiquitously expressed, and Dmc1, which is meiosis-specific. The evolutionary origins of this two-recombinase system remain poorly understood. Interestingly, Dmc1 can stabi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::204b5455f419591e8b30495acaed412f
https://doi.org/10.1101/gad.328062.119
https://doi.org/10.1101/gad.328062.119
Autor:
Denis Lazarev, James L. Manley, Takashi Yamazaki, Stuart M. Chambers, Lizhi Liu, Amr Al-Zain, Lorenz Studer, Percy Luk Yeung, Vitalay Fomin, Chi Wei Lu
Publikováno v:
Genes & Development. 33:733-736
Alternative splicing (AS) plays important roles in embryonic stem cell (ESC) differentiation. In this study, we first identified transcripts that display specific AS patterns in pluripotent human ESCs (hESCs) relative to differentiated cells. One of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c41b5f3b4de65bc1f08d1591a246cb98
https://doi.org/10.1101/gad.326983.119
https://doi.org/10.1101/gad.326983.119
Autor:
Stuart M. Chambers, Chi-Wei Lu, James L. Manley, Vitalay Fomin, Percy Luk Yeung, Lorenz Studer, Takashi Yamazaki, Denis Lazarev, Lizhi Liu, Amr Al-Zain
Publikováno v:
Genes & Development. 32:1161-1174
Alternative splicing (AS) plays important roles in embryonic stem cell (ESC) differentiation. In this study, we first identified transcripts that display specific AS patterns in pluripotent human ESCs (hESCs) relative to differentiated cells. One of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ddf4a83d52d985998837b6e13c2476f
https://doi.org/10.1101/gad.316984.118
https://doi.org/10.1101/gad.316984.118
Autor:
Amr Al-Zain, Lorraine S. Symington
Publikováno v:
DNA Repair. 106:103181
DNA double strand breaks (DSB) are cytotoxic lesions that can lead to genome rearrangements and genomic instability, which are hallmarks of cancer. The two main DSB repair pathways are non-homologous end joining and homologous recombination (HR). Whi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b79aaa89569a9300505c03054d0e22d2
https://doi.org/10.1016/j.dnarep.2021.103181
https://doi.org/10.1016/j.dnarep.2021.103181
Autor:
Zhi-Xiong Zhou, Roberto A. Donnianni, Eleanor Glancy, Valerie E Garcia, Thomas A. Kunkel, Adam B. Burkholder, Scott A. Lujan, Amr Al-Zain, Lorraine S. Symington
Publikováno v:
Molecular cell. 76(3)
Break-induced replication (BIR) is a pathway of homology-directed repair that repairs one-ended DNA breaks, such as those formed at broken replication forks or uncapped telomeres. In contrast to conventional S phase DNA synthesis, BIR proceeds by a m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f497d596370c2c271d76a34dfb97a24a
https://pubmed.ncbi.nlm.nih.gov/31495565
https://pubmed.ncbi.nlm.nih.gov/31495565
Publikováno v:
Molecular Biology of the Cell
DNA replication has to be tightly regulated to ensure genome integrity such that DNA replication takes place only once per cell cycle. The Cdc6 sequential phosphorylation by GSK-3 and Cdk1 creates a binding site for Cdc4 ubiquitin ligase to promote C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89a24456fe6c21717c2440cc1489c167
https://doi.org/10.1091/mbc.e14-07-1213
https://doi.org/10.1091/mbc.e14-07-1213
Cellular wound healing or the repair of plasma membrane/cell wall damage (plasma membrane damage) occurs frequently in nature. Although various cellular perturbations, such as DNA damage, spindle misalignment, and impaired daughter cell formation, ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6d2485cf18ea9c4ffa0bf13ccdda01f
https://europepmc.org/articles/PMC4922162/
https://europepmc.org/articles/PMC4922162/
Publikováno v:
Molecular cell
The Mre11-Rad50-Xrs2/Nbs1 (MRX/N) complex orchestrates the cellular response to DSBs through its structural, enzymatic, and signaling roles. Xrs2/Nbs1 is essential for nuclear translocation of Mre11, but its role as a component of the complex is not
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e55e92f2b4c12cc90aec526c9206041
https://pubmed.ncbi.nlm.nih.gov/27746018
https://pubmed.ncbi.nlm.nih.gov/27746018