Zobrazeno 1 - 10
of 108
pro vyhledávání: '"AmpliChip CYP450 Test"'
Autor:
Kristina Martens, Vasyl Yavorskyy, Ole Mors, Joshua Hague, Wolfgang Maier, Daniel Souery, Neven Henigsberg, Gerald Pfeffer, Rachael Dong, Annamaria Cattaneo, Joanna Hauser, Marcella Rietschel, Keanna Wallace, Avery Buchner, Stacey Hume, Michael Carr, Yabing Wang, Bahareh Behroozi Asl, Mojca Z. Dernovsek, Sudhakar Sivapalan, Katherine J. Aitchison, Beatriz Carvalho Henriques, Xiuying Hu
Publikováno v:
Translational Psychiatry
Carvalho Henriques, B, Buchner, A, Hu, X, Wang, Y, Yavorskyy, V, Wallace, K, Dong, R, Martens, K, Carr, M S, Behroozi Asl, B, Hague, J, Sivapalan, S, Maier, W, Dernovsek, M Z, Henigsberg, N, Hauser, J, Souery, D, Cattaneo, A, Mors, O, Rietschel, M, Pfeffer, G, Hume, S & Aitchison, K J 2021, ' Methodology for clinical genotyping of CYP2D6 and CYP2C19 ', Translational Psychiatry, vol. 11, no. 1, 596 . https://doi.org/10.1038/s41398-021-01717-9
Translational Psychiatry, Vol 11, Iss 1, Pp 1-9 (2021)
Carvalho Henriques, B, Buchner, A, Hu, X, Wang, Y, Yavorskyy, V, Wallace, K, Dong, R, Martens, K, Carr, M S, Behroozi Asl, B, Hague, J, Sivapalan, S, Maier, W, Dernovsek, M Z, Henigsberg, N, Hauser, J, Souery, D, Cattaneo, A, Mors, O, Rietschel, M, Pfeffer, G, Hume, S & Aitchison, K J 2021, ' Methodology for clinical genotyping of CYP2D6 and CYP2C19 ', Translational Psychiatry, vol. 11, no. 1, 596 . https://doi.org/10.1038/s41398-021-01717-9
Translational Psychiatry, Vol 11, Iss 1, Pp 1-9 (2021)
Many antidepressants, atomoxetine, and several antipsychotics are metabolized by the cytochrome P450 enzymes CYP2D6 and CYP2C19, and guidelines for prescribers based on genetic variants exist. Although some laboratories offer such testing, there is n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbda9fb5d1be2e4b6d723589b333df69
https://doi.org/10.1038/s41398-021-01717-9
https://doi.org/10.1038/s41398-021-01717-9
Autor:
Beatriz Carvalho Henriques, Amanda Buchner, Xiuying Hu, Vasyl Yavorskyy, Yabing Wang, Kristina Martens, Michael Carr, Bahareh Behroozi Asl, Joshua Hague, Wolfgang Maier, Mojca Z. Dernovsek, Neven Henigsberg, Daniel Souery, Annamaria Cattaneo, Joanna Hauser, Ole Mors, Marcella Rietschel, Gerald Pfeffer, Chad Bousman, Katherine J. Aitchison
BackgroundCYP2D6 and CYP2C19 are cytochrome P450 enzymes involved in the metabolism of many medications from multiple therapeutic classes. Associations between patterns of variants (known as haplotypes) in the genes encoding them (CYP2D6andCYP2C19) a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f96cced01527789c782ce44558c8321
Autor:
Seyed Yahya Anvar, Henk P. J. Buermans, Henk-Jan Guchelaar, Rolf H. A. M. Vossen, Johan T. den Dunnen, William G. Allard, Tahar van der Straaten, Stefan J. White, Jesse J. Swen
Publikováno v:
Human Mutation
Human Mutation, 38(3), 310-316
Human Mutation, 38(3), 310-316
Cytochrome P450 2D6 (CYP2D6) is among the most important genes involved in drug metabolism. Specific variants are associated with changes in the enzyme's amount and activity. Multiple technologies exist to determine these variants, like the AmpliChip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8ee17656a50a1ab9345b6ace8754fe1
http://europepmc.org/articles/PMC5324676
http://europepmc.org/articles/PMC5324676
Publikováno v:
The American Journal of Emergency Medicine. 34:245-249
Background CYP450 polymorphisms result in variable rates of drug metabolism. CYP drug-drug interactions can contribute to altered drug effectiveness and safety. Study objectives The primary objective was to determine the percentage of emergency depar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7103c56d2b70e85964cac049b17ce6a
https://doi.org/10.1016/j.ajem.2015.10.055
https://doi.org/10.1016/j.ajem.2015.10.055
Autor:
Natchaya Vanwong, Chonlaphat Sukasem, Monpat Chamnanphon, Nopphadol Nuntamool, Apichaya Puangpetch, Andrea Gaedigk, Yaowaluck Hongkaew
Publikováno v:
Pharmacogenomics. 19(12)
The highly polymorphic CYP2D6 gene locus leads to a wide range of enzyme activity. Since there are limited data for Thai, the major aim was to investigate CYP2D6 genetic variation in a large Thai population (n = 920). CYP2D6 genotyping was performed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d645cf39fd0b11e3545fc178f602029e
https://pubmed.ncbi.nlm.nih.gov/29992861
https://pubmed.ncbi.nlm.nih.gov/29992861
Autor:
Spencer B Chau, Roger E. Thomas
Publikováno v:
Current Drug Safety. 10:113-124
Background In 2005, the FDA approved the Roche AmpliChip™ for clinical application. The AmpliChip is a microarray chip that has the capability to play an important role in clinical pharmacogenetics. Objective Because of the possible influence the A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58e32711c43aab12f1444e312088cf04
https://doi.org/10.2174/1574886309666140428121036
https://doi.org/10.2174/1574886309666140428121036
Autor:
Ata Secilmis, Berksoy Sahin, Berna Bozkurt Duman, Abdullah Tuli, Meral Gunaldi, Cigdem Usul Afsar, Vehbi Ercolak, Ismail Oguz Kara, Semra Paydas, Melek Erkisi
Publikováno v:
International Journal of Hematology and Oncology. 24:157-162
In this study we investigated the role of the polymorphic types of CYP2D6 in the Turkish population for therapeutic efficacy among patients with early stage breast cancer who treated with tamoxifen. CYP2D6 plays an important role in tamoxifen metabol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ed070b5fb237254b84289839bd4d66c9
https://doi.org/10.4999/uhod.14453
https://doi.org/10.4999/uhod.14453
Publikováno v:
International Journal of Legal Medicine. 127:395-404
Genetic polymorphisms in cytochrome P 450 (CYP) enzymes could lead to a phenotype with altered enzyme activity. In pharmacotherapy, genotype-based dose recommendations achieved great importance for several drugs. In our pilot study, we ask if these g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcc8b9635621ff30f081734c0c31c809
https://doi.org/10.1007/s00414-012-0759-6
https://doi.org/10.1007/s00414-012-0759-6
Autor:
Jeffrey A. Lieberman, Margaret A. Richter, Rudi Hwang, Arun K. Tiwari, Jessica E. Sturgess, James L. Kennedy, Clement C. Zai, Eva J. Brandl, Daniel J. Müller
Publikováno v:
Genetic Testing and Molecular Biomarkers. 16:897-903
Genetic factors can result in variance in drug metabolism enzyme function, which is one major mechanism impacting on interindividual variability in response and side effects. We therefore performed a pilot study to investigate genetic variants in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1034581852b889995147139b8e10ffd2
https://doi.org/10.1089/gtmb.2011.0327
https://doi.org/10.1089/gtmb.2011.0327
Publikováno v:
Pharmacogenomics, 16(7), 681-687
Aim: The aim of this study was to investigate the concordance between the novel GenoChip CYP2D6 macroarray and the AmpliChip, which is considered the gold standard in CYP2D6 genotyping. Materials & methods: Germline DNA of 200 patients was genotyped
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a65fdbe55127f51f176b4fb636254f39
https://doi.org/10.2217/pgs.15.30
https://doi.org/10.2217/pgs.15.30