Single nucleus pituitary transcriptomic and epigenetic landscape reveals human stem cell heterogeneity with diverse regulatory mechanisms

Autor: Yianni, Zinan Zhang, Thea L. Willis, Daniel J. Bernard, Nitish Seenarine, Amper Mas, Frederique Ruf-Zamojski, Mital Vasoya, Venugopalan D. Nair, Cynthia L. Andoniadou, Olga G. Troyanskaya, Michel Zamojski, Turgeon Jl, Gregory R. Smith, Stuart C. Sealfon, Hanna Pincas, Natalia Mendelev

Despite their importance in tissue homeostasis and renewal, human pituitary stem cells (PSCs) are incompletely characterized. We describe a human single nucleus (sn) RNAseq and ATACseq resource from pediatric, adult, and aged pituitaries (snpituitary

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5df03c3de7bc89902f87d72b5539cefe
https://doi.org/10.1101/2021.06.18.449034

Protocol for high-throughput DNA methylation profiling in rat tissues using automated reduced representation bisulfite sequencing.

Autor: Nair VD; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address: venugopalan.nair@mountsinai.org., Pincas H; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Amper MAS; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Ge Y; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Vasoya M; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Raja AN; Department of Medicine, Stanford School of Medicine, Stanford, CA 94305, USA., Walsh MJ; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Sealfon SC; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address: stuart.sealfon@mssm.edu.

Publikováno v: STAR protocols [STAR Protoc] 2024 Jun 21; Vol. 5 (2), pp. 103007. Date of Electronic Publication: 2024 Apr 30.

Integrated epigenomic exposure signature discovery.

Autor: Schuetter J; Health Business Unit, Battelle Memorial Institute, Columbus, OH 43201, USA., Minard-Smith A; Health Business Unit, Battelle Memorial Institute, Columbus, OH 43201, USA., Hill B; Nationwide Insurance, Columbus, OH 43215, USA., Beare JL; Health Business Unit, Battelle Memorial Institute, Columbus, OH 43201, USA., Vornholt A; Icahn School of Medicine at Mount Sinai, New York City, NY 10029, 10029USA., Burke TW; Division of Infectious Diseases, Duke University, Durham, NC 27710, USA., Murugan V; Center for Personalized Diagnostics, Biodesign Institute at Arizona State University, Tempe, AZ 85281, 85281USA., Smith AK; Health Business Unit, Battelle Memorial Institute, Columbus, OH 43201, USA., Chandrasekaran T; Center for Personalized Diagnostics, Biodesign Institute at Arizona State University, Tempe, AZ 85281, 85281USA., Shamma HJ; Health Business Unit, Battelle Memorial Institute, Columbus, OH 43201, USA., Kahaian SC; Health Business Unit, Battelle Memorial Institute, Columbus, OH 43201, USA., Fillinger KL; Health Business Unit, Battelle Memorial Institute, Columbus, OH 43201, USA., Amper MAS; Icahn School of Medicine at Mount Sinai, New York City, NY 10029, 10029USA., Cheng WS; Icahn School of Medicine at Mount Sinai, New York City, NY 10029, 10029USA., Ge Y; Icahn School of Medicine at Mount Sinai, New York City, NY 10029, 10029USA., George MC; Icahn School of Medicine at Mount Sinai, New York City, NY 10029, 10029USA., Guevara K; Icahn School of Medicine at Mount Sinai, New York City, NY 10029, 10029USA., Lovette-Okwara N; Icahn School of Medicine at Mount Sinai, New York City, NY 10029, 10029USA., Mahajan A; Icahn School of Medicine at Mount Sinai, New York City, NY 10029, 10029USA., Marjanovic N; Icahn School of Medicine at Mount Sinai, New York City, NY 10029, 10029USA., Mendelev N; Icahn School of Medicine at Mount Sinai, New York City, NY 10029, 10029USA., Fowler VG; Division of Infectious Diseases, Duke University, Durham, NC 27710, USA., McClain MT; Division of Infectious Diseases, Duke University, Durham, NC 27710, USA., Miller CM; Icahn School of Medicine at Mount Sinai, New York City, NY 10029, 10029USA., Mofsowitz S; Icahn School of Medicine at Mount Sinai, New York City, NY 10029, 10029USA., Nair VD; Icahn School of Medicine at Mount Sinai, New York City, NY 10029, 10029USA., Nudelman G; Icahn School of Medicine at Mount Sinai, New York City, NY 10029, 10029USA., Evans TG; Barinthus Biotherapeutics, Harwell, Oxfordshire, UK., Castellino F; Biomedical Advanced Research & Development Authority-Administration for Strategic Preparedness & Response,Washington, DC 20201, USA., Ramos I; Icahn School of Medicine at Mount Sinai, New York City, NY 10029, 10029USA., Rirak S; Icahn School of Medicine at Mount Sinai, New York City, NY 10029, 10029USA., Ruf-Zamojski F; Icahn School of Medicine at Mount Sinai, New York City, NY 10029, 10029USA., Seenarine N; Icahn School of Medicine at Mount Sinai, New York City, NY 10029, 10029USA., Soares-Shanoski A; Icahn School of Medicine at Mount Sinai, New York City, NY 10029, 10029USA., Vangeti S; Icahn School of Medicine at Mount Sinai, New York City, NY 10029, 10029USA., Vasoya M; Icahn School of Medicine at Mount Sinai, New York City, NY 10029, 10029USA., Yu X; Icahn School of Medicine at Mount Sinai, New York City, NY 10029, 10029USA., Zaslavsky E; Icahn School of Medicine at Mount Sinai, New York City, NY 10029, 10029USA., Ndhlovu LC; Division of Infectious Diseases, Department of Medicine, Weill Cornell Medicine, New York, NY 10021, USA., Corley MJ; Division of Infectious Diseases, Department of Medicine, Weill Cornell Medicine, New York, NY 10021, USA., Bowler S; Division of Infectious Diseases, Department of Medicine, Weill Cornell Medicine, New York, NY 10021, USA., Deeks SG; University of California San Francisco, San Francisco, CA 94143, 94143USA., Letizia AG; Naval Medical Research Unit INDO PACIFIC, Singapore., Sealfon SC; Icahn School of Medicine at Mount Sinai, New York City, NY 10029, 10029USA., Woods CW; Division of Infectious Diseases, Duke University, Durham, NC 27710, USA., Spurbeck RR; Health Business Unit, Battelle Memorial Institute, Columbus, OH 43201, USA.

Publikováno v: Epigenomics [Epigenomics] 2024; Vol. 16 (14), pp. 1013-1029. Date of Electronic Publication: 2024 Sep 03.

Integrated single-cell multiome analysis reveals muscle fiber-type gene regulatory circuitry modulated by endurance exercise.

Autor: Rubenstein AB; Department of Neurology, Icahn School of Medicine at Mount Sinai (ISMMS), New York, NY 10029, USA., Smith GR; Department of Neurology, Icahn School of Medicine at Mount Sinai (ISMMS), New York, NY 10029, USA., Zhang Z; Department of Neurology, Icahn School of Medicine at Mount Sinai (ISMMS), New York, NY 10029, USA.; Lewis-Sigler Institute of Integrative Genomics, Princeton University, Princeton, NJ 08544, USA., Chen X; Center for Computational Biology, Flatiron Institute, Simons Foundation, New York, NY 10010, USA., Chambers TL; Human Performance Laboratory, Ball State University, Muncie, IN 47306, USA., Ruf-Zamojski F; Department of Neurology, Icahn School of Medicine at Mount Sinai (ISMMS), New York, NY 10029, USA.; Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA., Mendelev N; Department of Neurology, Icahn School of Medicine at Mount Sinai (ISMMS), New York, NY 10029, USA., Cheng WS; Department of Neurology, Icahn School of Medicine at Mount Sinai (ISMMS), New York, NY 10029, USA., Zamojski M; Department of Neurology, Icahn School of Medicine at Mount Sinai (ISMMS), New York, NY 10029, USA.; Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA., Amper MAS; Department of Neurology, Icahn School of Medicine at Mount Sinai (ISMMS), New York, NY 10029, USA., Nair VD; Department of Neurology, Icahn School of Medicine at Mount Sinai (ISMMS), New York, NY 10029, USA., Marderstein AR; Department of Genetics, Stanford University, Stanford, CA 94305, USA.; Department of Pathology, Stanford University, Stanford, CA 94305, USA., Montgomery SB; Department of Genetics, Stanford University, Stanford, CA 94305, USA.; Department of Pathology, Stanford University, Stanford, CA 94305, USA., Troyanskaya OG; Lewis-Sigler Institute of Integrative Genomics, Princeton University, Princeton, NJ 08544, USA.; Center for Computational Biology, Flatiron Institute, Simons Foundation, New York, NY 10010, USA.; Department of Computer Science, Princeton University, Princeton, NJ 08544, USA., Zaslavsky E; Department of Neurology, Icahn School of Medicine at Mount Sinai (ISMMS), New York, NY 10029, USA., Trappe T; Human Performance Laboratory, Ball State University, Muncie, IN 47306, USA., Trappe S; Human Performance Laboratory, Ball State University, Muncie, IN 47306, USA.; Senior author., Sealfon SC; Department of Neurology, Icahn School of Medicine at Mount Sinai (ISMMS), New York, NY 10029, USA.; Department of Computer Science, Princeton University, Princeton, NJ 08544, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Oct 09. Date of Electronic Publication: 2023 Oct 09.

Pre-infection antiviral innate immunity contributes to sex differences in SARS-CoV-2 infection.

Autor: Sauerwald N; Center for Computational Biology, Flatiron Institute, New York, NY 10010, USA., Zhang Z; Center for Computational Biology, Flatiron Institute, New York, NY 10010, USA., Ramos I; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Nair VD; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Soares-Schanoski A; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Ge Y; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Mao W; Department of Computational and Systems Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA., Alshammary H; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Gonzalez-Reiche AS; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., van de Guchte A; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Goforth CW; Naval Medical Research Center, Silver Spring, MD 20910, USA., Lizewski RA; Naval Medical Research Unit 6, Lima 34031, Peru., Lizewski SE; Naval Medical Research Unit 6, Lima 34031, Peru., Amper MAS; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Vasoya M; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Seenarine N; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Guevara K; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Marjanovic N; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Miller CM; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Nudelman G; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Schilling MA; Naval Medical Research Center, Silver Spring, MD 20910, USA., Sealfon RSG; Center for Computational Biology, Flatiron Institute, New York, NY 10010, USA., Termini MS; Navy Medicine Readiness and Training Command Beaufort, Beaufort, SC 29902, USA., Vangeti S; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Weir DL; Naval Medical Research Center, Silver Spring, MD 20910, USA., Zaslavsky E; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Chikina M; Department of Computational and Systems Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA., Wu YN; Department of Statistics, University of California, Los Angeles, Los Angeles, CA 90095, USA., Van Bakel H; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Letizia AG; Naval Medical Research Center, Silver Spring, MD 20910, USA., Sealfon SC; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address: stuart.sealfon@mssm.edu., Troyanskaya OG; Center for Computational Biology, Flatiron Institute, New York, NY 10010, USA; Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08540, USA; Department of Computer Science, Princeton University, Princeton, NJ 08540, USA. Electronic address: ogt@genomics.princeton.edu.

Publikováno v: Cell systems [Cell Syst] 2022 Nov 16; Vol. 13 (11), pp. 924-931.e4. Date of Electronic Publication: 2022 Nov 01.