Cyclophilin B serum levels present variations across the menstrual cycle

Autor: Rebeca Alvariño, Cristina Gil-Mouce, Manuel A. Botana, Sandra Gegunde, Jesús González-Jartín, Mercedes R. Vieytes, Amparo Alfonso, Luis M. Botana

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-7 (2023)

Abstract Cyclophilins are a family of chaperones involved in inflammation and cell death. Cyclophilin B is released by inflammatory cells and acts through the receptor CD147, affecting matrix metalloproteases release, whilst cyclophilin D participate

Externí odkaz: https://doaj.org/article/9e7d78d6ab8b46409c514cbe04740722

Association of cyclophilins and cardiovascular risk factors in coronary artery disease

Autor: Sandra Gegunde, Amparo Alfonso, Rebeca Alvariño, Nadia Pérez-Fuentes, Jeremías Bayón-Lorenzo, Eva Alonso, Raymundo Ocaranza-Sánchez, Rosa Alba Abellás-Sequeiros, Melisa Santás-Álvarez, Mercedes R. Vieytes, Carlos Juanatey-González, Luis M. Botana

Publikováno v: Frontiers in Physiology, Vol 14 (2023)

Cyclophilins are chaperone proteins that play important roles in signal transduction. Among them, cyclophilins A, B, C, and D were widely associated with inflammation and cardiovascular diseases. Cyclophilins A and C have been proposed as coronary ar

Externí odkaz: https://doaj.org/article/2b8f360f081d4f7b97144d5083c53e4e

Marine-Derived Components: Can They Be a Potential Therapeutic Approach to Parkinson’s Disease?

Autor: Joana Silva, Celso Alves, Francisca Soledade, Alice Martins, Susete Pinteus, Helena Gaspar, Amparo Alfonso, Rui Pedrosa

Publikováno v: Marine Drugs, Vol 21, Iss 8, p 451 (2023)

The increase in the life expectancy average has led to a growing elderly population, thus leading to a prevalence of neurodegenerative disorders, such as Parkinson’s disease (PD). PD is the second most common neurodegenerative disorder and is chara

Externí odkaz: https://doaj.org/article/2ed8570108ea4d66b3e72a6d8dc6042f

Bromoditerpenes from the Red Seaweed Sphaerococcus coronopifolius as Potential Cytotoxic Agents and Proteasome Inhibitors and Related Mechanisms of Action

Autor: Celso Alves, Joana Silva, Susete Pintéus, Romina A. Guedes, Rita C. Guedes, Rebeca Alvariño, Rafaela Freitas, Márcia I. Goettert, Helena Gaspar, Amparo Alfonso, Maria C. Alpoím, Luis M. Botana, Rui Pedrosa

Publikováno v: Marine Drugs, Vol 20, Iss 10, p 652 (2022)

Seaweeds are a great source of compounds with cytotoxic properties with the potential to be used as anticancer agents. This study evaluated the cytotoxic and proteasome inhibitory activities of 12R-hydroxy-bromosphaerol, 12S-hydroxy-bromosphaerol, an

Externí odkaz: https://doaj.org/article/bc54545d70a44a7d8be2f79dfe2a9a41

Interlaboratory Evaluation of Multiple LC-MS/MS Methods and a Commercial ELISA Method for Determination of Tetrodotoxin in Oysters and Mussels

Autor: Andrew D Turner, Karl J Dean, Monika Dhanji-Rapkova, Sonia Dall’Ara, Florella Pino, Claire McVey, Simon Haughey, Natasha Logan, Christopher Elliott, Ana Gago-Martinez, Jose Manuel Leao, Jorge Giraldez, Ryan Gibbs, Krista Thomas, Ruth Perez-Calderon, Dermot Faulkner, Hugh McEneny, Veronique Savar, Damien Reveillon, Philipp Hess, Fabiola Arevalo, J Pablo Lamas, Eva Cagide, Mercedes Alvarez, Alvaro Antelo, Mirjam D Klijnstra, Michalina Oplatowska-Stachowiak, Tim Kleintjens, Nermin Sajic, Michael J Boundy, Benjamin H Maskrey, D Tim Harwood, Jesús M González Jartín, Amparo Alfonso, Luis Botana

Publikováno v: Journal of AOAC International, 106(2), 356-369
Journal Of Aoac International (1060-3271) (Oxford University Press (OUP)), 2023-03, Vol. 106, N. 2, P. 356-369
Journal of AOAC International 106 (2023) 2

BackgroundGiven the recent detection of tetrodotoxin (TTX) in bivalve molluscs but the absence of a full collaborative validation study for TTX determination in a large number of shellfish samples, interlaboratory assessment of method performance was

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::540c5c6acedc883c5d846314f24345a1
https://doi.org/10.1093/jaoacint/qsad006