Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Amos, Baruch"'
Autor:
Chenguang Zhou, Hao Cai, Amos Baruch, Nicholas Lewin-Koh, Meng Yang, Fengxun Guo, Deming Xu, Rong Deng, Wouter Hazenbos, Amrita V Kamath
Publikováno v:
PLoS ONE, Vol 14, Iss 10, p e0224096 (2019)
Staphylococcus aureus (S. aureus) infections are a leading cause of death by an infectious agent. Survival within host phagocytic cells is one mechanism by which S. aureus evades antibiotic treatment. A novel THIOMAB™ antibody-antibiotic conjugate
Externí odkaz:
https://doaj.org/article/8846a354eb7b4b60b1c88b04faeba3db
Autor:
Ganesh Kolumam, Mark Z. Chen, Raymond Tong, Jose Zavala-Solorio, Lance Kates, Nicholas van Bruggen, Jed Ross, Shelby K. Wyatt, Vineela D. Gandham, Richard A.D. Carano, Diana Ronai Dunshee, Ai-Luen Wu, Benjamin Haley, Keith Anderson, Søren Warming, Xin Y. Rairdan, Nicholas Lewin-Koh, Yingnan Zhang, Johnny Gutierrez, Amos Baruch, Thomas R. Gelzleichter, Dale Stevens, Sharmila Rajan, Travis W. Bainbridge, Jean-Michel Vernes, Y. Gloria Meng, James Ziai, Robert H. Soriano, Matthew J. Brauer, Yongmei Chen, Scott Stawicki, Hok Seon Kim, Laëtitia Comps-Agrar, Elizabeth Luis, Christoph Spiess, Yan Wu, James A. Ernst, Owen P. McGuinness, Andrew S. Peterson, Junichiro Sonoda
Publikováno v:
EBioMedicine, Vol 2, Iss 7, Pp 730-743 (2015)
Dissipating excess calories as heat through therapeutic stimulation of brown adipose tissues (BAT) has been proposed as a potential treatment for obesity-linked disorders. Here, we describe the generation of a humanized effector-less bispecific antib
Externí odkaz:
https://doaj.org/article/acbf9281cbc1473db78d9eaceadaf5d7
Autor:
Chin Wong, Thomas Gelzleichter, Junichiro Sonoda, Amos Baruch, Linda Morrow, Suresh Dheerendra, Leslie W. Chinn, Richard Boismenu, Eric Wakshull, Maria E. Wilson, Puneet S. Arora, Shan Chen, Anjali Vaze, Johnny Gutierrez, Nicholas Lewin-Koh
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Fibroblast growth factor 21 (FGF21) controls metabolic organ homeostasis and eating behavior via FGF receptor 1/Klothoβ (FGFR1/KLB) complexes. Here we show that a bispecific anti-FGFR1/KLB agonist antibody, BFKB8488A, mimics the actions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecb1e6fc5999a3fd66bc3ad16e368b18
https://doi.org/10.1073/pnas.2012073117
https://doi.org/10.1073/pnas.2012073117
Autor:
James T. Koerber, Tracy Staton, Tangsheng Yi, Meire Bremer, Henry R. Maun, Saloumeh K Fischer, Robert A. Lazarus, Gizette Sperinde, Amos Baruch, Rajesh Vij
Publikováno v:
Bioanalysis. 12:1377-1388
Aim: Tryptase is a tetrameric trypsin-like serine protease contained within the secretory granules of mast cells and is an important mediator of allergic inflammatory responses in respiratory diseases. Detection of active tryptase in the airway may p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f116861e4dd77d7b88babbc01cb62715
https://doi.org/10.4155/bio-2020-0182
https://doi.org/10.4155/bio-2020-0182
Autor:
Amos Baruch, Kenneth J. Katschke, Victoria Pham, Shadi Toghi Eshghi, Phillip Lai, Andrew Ah Young, Wei-Ching Liang, Jennie R. Lill, Chingwei V. Lee, Wei Li, Menno Van Lookeren Campagne, Johnny Gutierrez, Daniel Kirchhofer, Isabel Figueroa, Scott J. Snipas, Guy S. Salvesen, Irene Tom, Lee Honigberg, Jitendra Kanodia
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Genome-wide association studies have identified genetic variation at the ARMS2/HTRA1 locus as a risk factor for the development and progression of age-related macular degeneration (AMD). We have developed a potent anti-HtrA1 Fab inhibito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c4fe9632f4bd83a6b6e8467a0f8935b
https://doi.org/10.1073/pnas.1917608117
https://doi.org/10.1073/pnas.1917608117
Autor:
Amos Baruch, Derek Maclean
Publikováno v:
Successful Drug Discovery
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::95663a085740b570b71c70e87c67481a
https://doi.org/10.1002/9783527814695.ch5
https://doi.org/10.1002/9783527814695.ch5
Autor:
Amos Baruch, Karestan C. Koenen, Brian Tung, Janet Lo, Roger K. Pitman, Amorina Ishai, Jon T. Giles, Ahmed Tawakol, Lisa M. Shin, Ying Wang, Zahi A. Fayad, Basma Hammad, Michael T. Osborne, Steven K. Grinspoon
Publikováno v:
Psychoneuroendocrinology. 100:32-40
While it is established that psychosocial stress increases the risk of developing diabetes mellitus (DM), two key knowledge gaps remain: 1) the neurobiological mechanisms that are involved in mediating that risk, and 2) the role, if any, that adiposi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d41368021d9daf51b2f376e1da49719
https://doi.org/10.1016/j.psyneuen.2018.09.024
https://doi.org/10.1016/j.psyneuen.2018.09.024
Autor:
Sotirios Tsimikas, Amos Baruch, Harpreet S Bhatia, Erik S.G. Stroes, Calvin Yeang, Xiaohong Yang
Publikováno v:
Journal of the American College of Cardiology, 78(12), 1288-1289. Elsevier USA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d897a97bc8f37ddbe32d66fe75d3cf06
https://doi.org/10.1016/j.jacc.2021.07.031
https://doi.org/10.1016/j.jacc.2021.07.031
Autor:
Tiia Kittila, Jan Borén, Amos Baruch, Markus Perola, Juha Sinisalo, Mika Hilvo, Reijo Käkelä, Anton Gisterå, Seppo Ylä-Herttula, Kevin Jon Williams, Jenni Huusko, Markku J. Savolainen, Marc Baumann, Su Duy Nguyen, Matti Jauhiainen, Daniel F. J. Ketelhuth, Reijo Laaksonen, Matti Uusitupa, Anssi Öörni, Marja-Liisa Lokki, Pradeep Kumar Kondadi, Ursula Schwab, Lawrence L. Rudel, Tero Aittokallio, Teemu D. Laajala, Terhi Vihervaara, Katariina Öörni, Markku S. Nieminen, Antti Jula, Maija Ruuth, Hanna Lähteenmäki, Petri T. Kovanen
Publikováno v:
European Heart Journal
Aims: Low-density lipoprotein (LDL) particles cause atherosclerotic cardiovascular disease (ASCVD) through their retention, modification, and accumulation within the arterial intima. High plasma concentrations of LDL drive this disease, but LDL quali
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9529628604ada1de174beddfcf3a13c1
http://europepmc.org/articles/PMC6047440
http://europepmc.org/articles/PMC6047440
Autor:
Sharmila Rajan, Thomas Gelzleichter, Amos Baruch, Junichiro Sonoda, C. Andrew Boswell, Dale Stevens, Eric Stefanich, Danielle Mandikian, Kyra J. Cowan
Publikováno v:
mAbs. 9:1379-1388
Target receptor levels can influence pharmacokinetics (PK) or pharmacodynamics (PD) of monoclonal antibodies (mAbs), and can affect drug development of this class of molecules. We generated an effector-less humanized bispecific antibody that selectiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfe09bafc48ef65e54437fd42a8236af
https://doi.org/10.1080/19420862.2017.1373923
https://doi.org/10.1080/19420862.2017.1373923