Transformation of Amorphadiene Synthase and Antisilencing P19 Genes into Artemisia annua L. and its Effect on Antimalarial Artemisinin Production

Autor: Elfahmi Elfahmi, Fany Mutia Cahyani, Tati Kristianti, Sony Suhandono

Publikováno v: Advanced Pharmaceutical Bulletin, Vol 10, Iss 3, Pp 464-471 (2020)

Purpose: The low content of artemisinin related to the biosynthetic pathway is influenced by the role of certain enzymes in the formation of artemisinin. The regulation of genes involved in artemisinin biosynthesis through genetic engineering is a ch

Externí odkaz: https://doaj.org/article/88508ab7c8674c859e5c0209b07d524f

Debottlenecking mevalonate pathway for antimalarial drug precursor amorphadiene biosynthesis in Yarrowia lipolytica

Autor: Monireh Marsafari, Peng Xu

Publikováno v: Metabolic Engineering Communications, Vol 10, Iss , Pp e00121- (2020)

World Health Organization reports that half of the population in developing countries are at risk of malaria infection. Artemisinin, the most potent anti-malaria drug, is a sesquiterpene endoperoxide extracted from the plant Artemisia annua. Due to s

Externí odkaz: https://doaj.org/article/3234b524f4054a119f7b515a10bce549

Engineering of Multiple Modules to Improve Amorphadiene Production in Bacillus subtilis Using CRISPR-Cas9

Autor: Ingy I Abdallah, Wim J. Quax, Ronald van Merkerk, Siqi He, Pieter G. Tepper, Anita Jopkiewicz, Yafeng Song, Rita Setroikromo

Publikováno v: Journal of Agricultural and Food Chemistry
Journal of Agricultural and Food Chemistry, 69(16), 4785-4794. AMER CHEMICAL SOC

Engineering strategies to improve terpenoids production in Bacillus subtilis mainly focus on 2C-methyl-D-erythritol-4-phosphate (MEP) pathway overexpression. To systematically engineer the chassis strain for higher amorphadiene (precursor of artemisi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::553dd0157271f5e7cf0ba6b541b5460b
https://doi.org/10.1021/acs.jafc.1c00498

Harnessing enzyme plasticity for the synthesis of oxygenated sesquiterpenoids

Autor: Rudolf Konrad Allemann, Melodi Demiray, David James Miller

Publikováno v: Beilstein Journal of Organic Chemistry
Beilstein Journal of Organic Chemistry, Vol 15, Iss 1, Pp 2184-2190 (2019)

8-Methoxy-γ-humulene, (E)-8-methoxy-β-farnesene, 12-methoxy-β-sesquiphellandrene and 12-methoxyzingiberene can be synthesised in amorphadiene synthase-catalysed reactions from 8- and 12-methoxyfarnesyl diphosphates due to the highly plastic yet ti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7699b647f5f8a53c54391547fec142f2
http://europepmc.org/articles/PMC6774066

Palladium-Catalyzed Regioselective Allylic Oxidation of Amorphadiene, a Precursor of Artemisinin

Autor: Geoffrey Schwertz, Mario Andrés Gomez Fernandez, Janine Cossy, Zacharias Amara, Marllon Nascimento de Oliveira, Andrea Zanetti

Publikováno v: Journal of Organic Chemistry
Journal of Organic Chemistry, American Chemical Society, 2021, 86 (11), pp.7603-7608. ⟨10.1021/acs.joc.1c00653⟩

This is the accepted manuscript version of the work published in its final form as Zanetti, A., Schwertz, G., Marllon Nascimento de Oliveira., Fernandez, M. A. G., Amara, Z., & Cossy, J. (2021). Palladium-Catalyzed Regioselective Allylic Oxidation of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05364dd0e2b6cbfa33f73fbf0bad3f06
https://hal.archives-ouvertes.fr/hal-03407657