A sulfonimide derivative of bezafibrate as a dual inhibitor of cyclooxygenase-2 and PPARα.

Autor: Ammazzalorso A; Department of Pharmacy, 'G. d'Annunzio' University, Chieti, Italy., Tacconelli S; Systems Pharmacology and Translational Therapeutics Laboratory, at the Center for Advanced Studies and Technology (CAST), and Department of Neuroscience, Imaging and Clinical Science, 'G. d'Annunzio' University, Chieti, Italy., Contursi A; Systems Pharmacology and Translational Therapeutics Laboratory, at the Center for Advanced Studies and Technology (CAST), and Department of Neuroscience, Imaging and Clinical Science, 'G. d'Annunzio' University, Chieti, Italy., Hofling U; Systems Pharmacology and Translational Therapeutics Laboratory, at the Center for Advanced Studies and Technology (CAST), and Department of Neuroscience, Imaging and Clinical Science, 'G. d'Annunzio' University, Chieti, Italy., Cerchia C; Department of Pharmaceutical and Toxicological Chemistry, University of Naples 'Federico II', Naples, Italy., Di Berardino S; Systems Pharmacology and Translational Therapeutics Laboratory, at the Center for Advanced Studies and Technology (CAST), and Department of Neuroscience, Imaging and Clinical Science, 'G. d'Annunzio' University, Chieti, Italy., De Michele A; Systems Pharmacology and Translational Therapeutics Laboratory, at the Center for Advanced Studies and Technology (CAST), and Department of Neuroscience, Imaging and Clinical Science, 'G. d'Annunzio' University, Chieti, Italy., Amoroso R; Department of Pharmacy, 'G. d'Annunzio' University, Chieti, Italy., Lavecchia A; Department of Pharmaceutical and Toxicological Chemistry, University of Naples 'Federico II', Naples, Italy., Patrignani P; Systems Pharmacology and Translational Therapeutics Laboratory, at the Center for Advanced Studies and Technology (CAST), and Department of Neuroscience, Imaging and Clinical Science, 'G. d'Annunzio' University, Chieti, Italy.

Publikováno v: Frontiers in pharmacology [Front Pharmacol] 2024 Nov 26; Vol. 15, pp. 1488722. Date of Electronic Publication: 2024 Nov 26 (Print Publication: 2024).

A novel life for antitumor combretastatins: Recent developments of hybrids, prodrugs, combination therapies, and antibody-drug conjugates.

Autor: Fantacuzzi M; Department of Pharmacy, 'G. d'Annunzio' University of Chieti-Pescara, Via dei Vestini 31, 66100, Chieti, Italy., Carradori S; Department of Pharmacy, 'G. d'Annunzio' University of Chieti-Pescara, Via dei Vestini 31, 66100, Chieti, Italy., Giampietro L; Department of Pharmacy, 'G. d'Annunzio' University of Chieti-Pescara, Via dei Vestini 31, 66100, Chieti, Italy., Maccallini C; Department of Pharmacy, 'G. d'Annunzio' University of Chieti-Pescara, Via dei Vestini 31, 66100, Chieti, Italy., De Filippis B; Department of Pharmacy, 'G. d'Annunzio' University of Chieti-Pescara, Via dei Vestini 31, 66100, Chieti, Italy., Amoroso R; Department of Pharmacy, 'G. d'Annunzio' University of Chieti-Pescara, Via dei Vestini 31, 66100, Chieti, Italy., Ammazzalorso A; Department of Pharmacy, 'G. d'Annunzio' University of Chieti-Pescara, Via dei Vestini 31, 66100, Chieti, Italy. Electronic address: alessandra.ammazzalorso@unich.it.

Publikováno v: European journal of medicinal chemistry [Eur J Med Chem] 2025 Jan 05; Vol. 281, pp. 117021. Date of Electronic Publication: 2024 Oct 31.

Advancements in the Research of New Modulators of Nitric Oxide Synthases Activity.

Autor: Maccallini C; Department of Pharmacy, University 'G. d'Annunzio' of Chieti-Pescara, Via dei Vestini 31, 66100 Chieti, Italy., Budriesi R; Department of Pharmacy and Biotechnology, Food Chemistry and Nutraceutical Lab, Alma Mater Studiorum-University of Bologna, 40126 Bologna, Italy., De Filippis B; Department of Pharmacy, University 'G. d'Annunzio' of Chieti-Pescara, Via dei Vestini 31, 66100 Chieti, Italy., Amoroso R; Department of Pharmacy, University 'G. d'Annunzio' of Chieti-Pescara, Via dei Vestini 31, 66100 Chieti, Italy.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2024 Aug 03; Vol. 25 (15). Date of Electronic Publication: 2024 Aug 03.

Neuronal Nitric Oxide Synthase and Post-Translational Modifications in the Development of Central Nervous System Diseases: Implications and Regulation.

Autor: Maccallini C; Department of Pharmacy, University 'G. d'Annunzio' of Chieti-Pescara, Via dei Vestini 31, 66100 Chieti, Italy., Amoroso R; Department of Pharmacy, University 'G. d'Annunzio' of Chieti-Pescara, Via dei Vestini 31, 66100 Chieti, Italy.

Publikováno v: Molecules (Basel, Switzerland) [Molecules] 2023 Sep 19; Vol. 28 (18). Date of Electronic Publication: 2023 Sep 19.

Anti-Inflammatory, Antioxidant, and WAT/BAT-Conversion Stimulation Induced by Novel PPAR Ligands: Results from Ex Vivo and In Vitro Studies.

Autor: Recinella L; Department of Pharmacy, G. d'Annunzio University, 66100 Chieti, Italy., De Filippis B; Department of Pharmacy, G. d'Annunzio University, 66100 Chieti, Italy., Libero ML; Department of Pharmacy, G. d'Annunzio University, 66100 Chieti, Italy., Ammazzalorso A; Department of Pharmacy, G. d'Annunzio University, 66100 Chieti, Italy., Chiavaroli A; Department of Pharmacy, G. d'Annunzio University, 66100 Chieti, Italy., Orlando G; Department of Pharmacy, G. d'Annunzio University, 66100 Chieti, Italy., Ferrante C; Department of Pharmacy, G. d'Annunzio University, 66100 Chieti, Italy., Giampietro L; Department of Pharmacy, G. d'Annunzio University, 66100 Chieti, Italy., Veschi S; Department of Pharmacy, G. d'Annunzio University, 66100 Chieti, Italy., Cama A; Department of Pharmacy, G. d'Annunzio University, 66100 Chieti, Italy., Mannino F; Department of Clinical and Experimental Medicine, University of Messina, 98122 Messina, Italy., Gasparo I; Department of Clinical and Experimental Medicine, University of Messina, 98122 Messina, Italy., Bitto A; Department of Clinical and Experimental Medicine, University of Messina, 98122 Messina, Italy., Amoroso R; Department of Pharmacy, G. d'Annunzio University, 66100 Chieti, Italy., Brunetti L; Department of Pharmacy, G. d'Annunzio University, 66100 Chieti, Italy., Leone S; Department of Pharmacy, G. d'Annunzio University, 66100 Chieti, Italy.

Publikováno v: Pharmaceuticals (Basel, Switzerland) [Pharmaceuticals (Basel)] 2023 Feb 24; Vol. 16 (3). Date of Electronic Publication: 2023 Feb 24.