Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Amoolya H. Singh"'
Autor:
Russell A. Judge, Janani Sridar, Kathryn Tunyasunvunakool, Rinku Jain, John C. K. Wang, Christna Ouch, Jun Xu, Amirhossein Mafi, Aaron H. Nile, Clint Remarcik, Corey L. Smith, Crystal Ghosh, Chen Xu, Vincent Stoll, John Jumper, Amoolya H. Singh, Dan Eaton, Qi Hao
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
PAPP-A substrate selectivity underlies the tight regulation of IGF signaling. Here, the authors report cryo-EM structures of dimeric PAPP-A in its substrate-free form and in complex with a peptide substrate, which combined with biochemical assays pro
Externí odkaz:
https://doaj.org/article/b5c3045813c44acc833427452b1f8434
Autor:
Russell A. Judge, Janani Sridar, Kathryn Tunyasuvunakool, Rinku Jain, John C. K. Wang, Christna Ouch, Jun Xu, Amirhossein Mafi, Aaron H. Nile, Clint Remarcik, Corey L. Smith, Crystal Ghosh, Chen Xu, Vincent Stoll, John Jumper, Amoolya H. Singh, Dan Eaton, Qi Hao
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/10c8d248d14e4e0f9396d0a4fdf025d6
Autor:
Amoolya H. Singh, Benjamin B. Kaufmann-Malaga, Joshua A. Lerman, Daniel P. Dougherty, Yang Zhang, Alexander L. Kilbo, Erin H. Wilson, Chiam Yu Ng, Onur Erbilgin, Kate A. Curran, Christopher D. Reeves, John E. Hung, Simone Mantovani, Zachary A. King, Marites J. Ayson, Judith R. Denery, Chia-Wei Lu, Phillip Norton, Carol Tran, Darren M. Platt, Joel R. Cherry, Sunil S. Chandran, Adam L. Meadows
Engineering microbes to synthesize molecules of societal value has historically been a time consuming and artisanal process, with the synthesis of each new non-native molecule typically warranting its own separate publication. Because most microbial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::494b4676c035c6da704381c0cce91660
https://doi.org/10.1101/2023.01.03.521657
https://doi.org/10.1101/2023.01.03.521657
Publikováno v:
Current opinion in biotechnology. 62
High-throughput screening is a critical part of any industrial strain engineering effort, helping ensure the lowest cost product is produced in the shortest amount of time. Small-scale testing that correlates to manufacturing scale allows rapid strai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::971149ec48477fa5d7a48e41a746112a
https://pubmed.ncbi.nlm.nih.gov/31513989
https://pubmed.ncbi.nlm.nih.gov/31513989
Publikováno v:
Metabolic Syndrome and Related Disorders. 8:355-363
Signaling events associated with diabetic nephropathy are not well understood. Triangulation of events triggered by unrelated bioactive peptides nephrilin and anephril, both of which inhibit albuminuria in diabetic mice, could reveal a common subset
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59a8bdcf39baeec39d6786eaa7791ae5
https://doi.org/10.1089/met.2010.0011
https://doi.org/10.1089/met.2010.0011
Autor:
Tobias Doerks, Eoghan D. Harrington, Lars Juhl Jensen, Jeroen Raes, Peer Bork, Amoolya H. Singh, Ivica Letunic, C. von Mering
Publikováno v:
Proceedings of the National Academy of Sciences. 104:13913-13918
To assess the potential of protein function prediction in environmental genomics data, we analyzed shotgun sequences from four diverse and complex habitats. Using homology searches as well as customized gene neighborhood methods that incorporate inte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e753826ebb0897a2402d9800622fec11
https://doi.org/10.1073/pnas.0702636104
https://doi.org/10.1073/pnas.0702636104
Publikováno v:
Journal of bacteriology. 191(1)
The emerging coverage of diverse habitats by metagenomic shotgun data opens new avenues of discovering functional novelty using computational tools. Here, we apply three different concepts for predicting novel functions within light-mediated microbia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d12200f1a6e9a87837a361c2fd472c3e
https://pubmed.ncbi.nlm.nih.gov/18849420
https://pubmed.ncbi.nlm.nih.gov/18849420
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 105(21)
Responses to extracellular stress directly confer survival fitness by means of complex regulatory networks. Despite their complexity, the networks must be evolvable because of changing ecological and environmental pressures. Although the regulatory n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::001d045dab27c9ac7001673d628e793a
https://pubmed.ncbi.nlm.nih.gov/18495925
https://pubmed.ncbi.nlm.nih.gov/18495925
Publikováno v:
Critical pathways in cardiology. 6(1)
The influence of continuing medical education (CME) on the adoption of new treatments is widely regarded as self-evident. Less well understood is how the dynamics of dissemination of new healthcare practices are influenced by the intersection of educ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be99576635a56857f4826d1194ab260e
https://pubmed.ncbi.nlm.nih.gov/17667885
https://pubmed.ncbi.nlm.nih.gov/17667885
Publikováno v:
Current opinion in structural biology. 17(3)
Given that the number of protein functions on earth is finite, the rapid expansion of biological knowledge and the concomitant exponential increase in the number of protein sequences should, at some point, enable the estimation of the limits of prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46bdb12fdff4ac1fa3f870e56c2179ba
https://pubmed.ncbi.nlm.nih.gov/17574832
https://pubmed.ncbi.nlm.nih.gov/17574832