Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Amol V Shivange"'
Autor:
Aaron L Nichols, Zack Blumenfeld, Chengcheng Fan, Laura Luebbert, Annet EM Blom, Bruce N Cohen, Jonathan S Marvin, Philip M Borden, Charlene H Kim, Anand K Muthusamy, Amol V Shivange, Hailey J Knox, Hugo Rego Campello, Jonathan H Wang, Dennis A Dougherty, Loren L Looger, Timothy Gallagher, Douglas C Rees, Henry A Lester
Publikováno v:
eLife, Vol 11 (2022)
Externí odkaz:
https://doaj.org/article/098460172c5e405ebfd89ac4744a4398
Autor:
Aaron L Nichols, Zack Blumenfeld, Chengcheng Fan, Laura Luebbert, Annet EM Blom, Bruce N Cohen, Jonathan S Marvin, Philip M Borden, Charlene H Kim, Anand K Muthusamy, Amol V Shivange, Hailey J Knox, Hugo Rego Campello, Jonathan H Wang, Dennis A Dougherty, Loren L Looger, Timothy Gallagher, Douglas C Rees, Henry A Lester
Publikováno v:
eLife, Vol 11 (2022)
Nicotinic partial agonists provide an accepted aid for smoking cessation and thus contribute to decreasing tobacco-related disease. Improved drugs constitute a continued area of study. However, there remains no reductionist method to examine the cell
Externí odkaz:
https://doaj.org/article/4b4e86491b454335b0724b76381431a8
Publikováno v:
PLoS ONE, Vol 6, Iss 10, p e26222 (2011)
Focused mutant library generation methods have been developed to improve mainly "localizable" enzyme properties such as activity and selectivity. Current multi-site saturation methods are restricted by the gene sequence, require subsequent PCR steps
Externí odkaz:
https://doaj.org/article/5e3e714e6b2648028332b834bf2f1569
Autor:
Kallol Bera, Aron Kamajaya, Amol V. Shivange, Anand K. Muthusamy, Aaron L. Nichols, Philip M. Borden, Stephen Grant, Janice Jeon, Elaine Lin, Ishak Bishara, Theodore M. Chin, Bruce N. Cohen, Charlene H. Kim, Elizabeth K. Unger, Lin Tian, Jonathan S. Marvin, Loren L. Looger, Henry A. Lester
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 13 (2019)
The target for the “rapid” (100-fold selectivity over other ligands tested, including R-ketamine. We targeted each of the sensors to either the plasma membrane (PM) or the endoplasmic reticulum (ER). Measurements on these biosensors expressed in
Externí odkaz:
https://doaj.org/article/4397d649b8754ebaa97c121f59eaa73b
Autor:
Zoe G, Beatty, Anand K, Muthusamy, Elizabeth K, Unger, Dennis A, Dougherty, Lin, Tian, Loren L, Looger, Amol V, Shivange, Kallol, Bera, Henry A, Lester, Aaron L, Nichols
Publikováno v:
Bio Protoc
Subcellular pharmacokinetic measurements have informed the study of central nervous system (CNS)–acting drug mechanisms. Recent investigations have been enhanced by the use of genetically encoded fluorescent biosensors for drugs of interest at the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9580feacb1a6314be6428bdfaea0719d
https://doi.org/10.21769/bioprotoc.4551
https://doi.org/10.21769/bioprotoc.4551
Autor:
Laura Luebbert, Chengcheng Fan, Zack Blumenfeld, Aaron L Nichols, Annet EM Blom, Bruce N Cohen, Jonathan S Marvin, Philip M Borden, Charlene H Kim, Anand K Muthusamy, Amol V Shivange, Hailey J Knox, Hugo Rego Campello, Jonathan H Wang, Dennis A Dougherty, Loren L Looger, Timothy Gallagher, Douglas C Rees, Henry A Lester
Publikováno v:
eLife, Vol 11 (2022)
Nicotinic partial agonists provide an accepted aid for smoking cessation and thus contribute to decreasing tobacco-related disease. Improved drugs constitute a continued area of study. However, there remains no reductionist method to examine the cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db5443311f3c81c64be58edbae07c241
https://elifesciences.org/articles/74648
https://elifesciences.org/articles/74648
Autor:
Laura Luebbert, Chengcheng Fan, Zack Blumenfeld, Aaron L Nichols, Annet EM Blom, Bruce N Cohen, Jonathan S Marvin, Philip M Borden, Charlene H Kim, Anand K Muthusamy, Amol V Shivange, Hailey J Knox, Hugo Rego Campello, Jonathan H Wang, Dennis A Dougherty, Loren L Looger, Timothy Gallagher, Douglas C Rees, Henry A Lester
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ba6d7547914bb271a0936a614e02ac3
https://doi.org/10.7554/elife.74648.sa2
https://doi.org/10.7554/elife.74648.sa2
Autor:
Jonathan S. Marvin, Amol V. Shivange, Hailey J. Knox, Loren L. Looger, Henry A. Lester, Charlene H. Kim, Annet E. M. Blom, C. Fan, Timothy Gallagher, Laura Luebbert, Philip M. Borden, Bruce N. Cohen, Aaron L. Nichols, Hugo Rego Campello, Dennis A. Dougherty, Jonathan H. Wang, Zack Blumenfeld, Douglas C. Rees, Anand K. Muthusamy
Nicotinic partial agonists provide an accepted aid for smoking cessation and thus contribute to decreasing tobacco-related disease. Improved drugs constitute a continued area of study. However, there remains no reductionist method to examine the cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::10a55da369175a588f45fdc48dd3e8e5
https://doi.org/10.1101/2021.10.04.463082
https://doi.org/10.1101/2021.10.04.463082
Autor:
Amol V. Shivange, Mamatha B. Nijaguna, Gayathri Sadasivam, Vadiraj Kurdekar, Vijay Potluri, Muralidhara Padigaru, Kavitha Bharatham, Jasti Subbarao, Saranya Giridharan, Ashok R. Venkitaraman, Jayaprakash Periasamy, Sanjana Boggaram
Publikováno v:
ChemMedChem. 14:1620-1632
The tandem BRCT domains (tBRCT) of BRCA1 engage phosphoserine-containing motifs in target proteins to propagate intracellular signals initiated by DNA damage, thereby controlling cell cycle arrest and DNA repair. Recently, we identified Bractoppin, t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbd2b15dd22a1f73a9aee11998c51fa0
https://doi.org/10.1002/cmdc.201900300
https://doi.org/10.1002/cmdc.201900300
Autor:
Philip M. Borden, Kallol Bera, Huan Bao, Bruce N. Cohen, Edwin R. Chapman, Ishak Bishara, Anand K. Muthusamy, Aaron L. Nichols, Jonathan S. Marvin, Amol V. Shivange, Loren L. Looger, Dennis A. Dougherty, Matthew J. Mulcahy, Charlene Kim, Janice Jeon, Saidhbhe L. O'Riordan, Henry A. Lester
Publikováno v:
The Journal of General Physiology
Nicotine dependence is thought to arise in part because nicotine permeates into the endoplasmic reticulum (ER), where it binds to nicotinic receptors (nAChRs) and begins an “inside-out” pathway that leads to up-regulation of nAChRs on the plasma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2c564a1cc8ddc98e43ee965c71f998b
https://doi.org/10.1085/jgp.201812201
https://doi.org/10.1085/jgp.201812201