Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Amol Mhetre"'
Herein, we report a selection approach to enrich ligands from DNA-encoded libraries (DELs) based on proximity to an enzymatic tag on the target protein. This method involves uncaging or installation of a biotin purification tag on the DNA construct e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::134aa2776e9a38e5757ec946e7d89fc6
https://doi.org/10.26434/chemrxiv-2022-l097f
https://doi.org/10.26434/chemrxiv-2022-l097f
Publikováno v:
Biochemistry. 60:1312-1324
The serine hydrolase (SH) superfamily is, perhaps, one of the largest functional enzyme classes in all forms of life and consists of proteases, peptidases, lipases, and carboxylesterases as representative members. Consistent with the name of this sup
Autor:
Neelay Mehendale, Abinaya Rajendran, Ajay Sharma, Amol Mhetre, G. Ravikumar, Siddhesh S. Kamat, Alaumy Joshi, Shubham Singh, Dhanashree S. Kelkar, Harinath Chakrapani
Publikováno v:
Nature chemical biology
Reactive oxygen species (ROS) are transient, highly reactive intermediates or byproducts produced during oxygen metabolism. However, when innate mechanisms are unable to cope with sequestration of surplus ROS, oxidative stress results, in which exces
Autor:
Dongyeol Lim, Rashmi Dubey, Ganesh A. Sable, Amol Mhetre, Heekyoung Yang, Kyoungmin Lee, Hangeun Lee, Do-Hyun Nam, Eppakayala Sreedhar
Publikováno v:
RSC Advances. 9:29023-29036
A diverse series of compounds (18a–x) were synthesized from (S)-1-(chloromethyl)-8-methoxy-2,3-dihydro-1H-benzo[e]indol-5-ol (seco-MCBI) and benzoselenophene or heteroaromatic acids. These new compounds were evaluated for their cytotoxicity against
Autor:
Alaumy Joshi, Siddhesh S. Kamat, Minhaj Shaikh, Abinaya Rajendran, Shubham Singh, Amol Mhetre
Publikováno v:
The Journal of Biological Chemistry
Polyneuropathy, hearing loss, ataxia, retinitis pigmentosa, and cataract (PHARC) is a rare genetic human neurological disorder caused by null mutations to the Abhd12 gene, which encodes the integral membrane serine hydrolase enzyme ABHD12. Although t
Publikováno v:
Biochemistry
The serine hydrolase (SH) superfamily is perhaps, one of the largest functional enzyme classes in all forms of life, and consists of proteases, peptidases, lipases, and carboxylesterases as representative members. Consistent with the name of this sup
Publikováno v:
J Membr Biol
Lysophospholipids are potent hormone-like signalling biological lipids that regulate many important biological processes in mammals (including humans). Lysophosphatidic acid and sphingosine-1-phosphate represent the best studied examples for this lip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5266cbe5c8a6eb047ee233e2b2c7bbb
https://europepmc.org/articles/PMC7116134/
https://europepmc.org/articles/PMC7116134/
Autor:
Ketan D. Patel, Murali Krishna Madduri, Priyadarshan Kinatukara, Avinash Soundararajan, P. Chandra Shekar, Siddhesh S. Kamat, Amol Mhetre, Purnima Sailasree Subramaniyan, Gajanan S. Patil, Rajan Sankaranarayanan, Shubham Singh, Satish Kumar, Sakshi Shambhavi
Publikováno v:
Transgenic research. 29(5-6)
Disco-interacting protein 2 is a highly conserved three-domain protein with two tandem Adenylate-forming domains. It is proposed to influence the processes involved in neuronal development by influencing lipid metabolism and remains to be characteriz
Autor:
Alaumy Joshi, Harinath Chakrapani, Siddhesh S. Kamat, Shubham Singh, Kithiganahalli Narayanaswamy Balaji, Amol Mhetre, Neha Khandelwal, Minhaj Shaikh, Theja Sajeevan
Publikováno v:
Cell Chem Biol
In humans, lysophosphatidylserines (lyso-PSs) are potent lipid regulators of important immunological processes. Given their structural diversity and commercial paucity, here, we report the synthesis of methyl-esters of lyso-PS (Me-lyso-PS), containin
Publikováno v:
Organic & Biomolecular Chemistry. 15:1198-1208
The current study reports the synthesis of different derivatives of benzoselenophene analogs as well as a diverse series of compounds (14a-p, 15 and 16) from 1,2,9,9a-tetrahydrocyclopropa[c]benzo[e]indol-4-one (CBI) and benzoselenophene or heteroarom