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Akademický článek

Nivolumab and ipilimumab with concurrent stereotactic radiosurgery for intracranial metastases from non-small cell lung cancer: analysis of the safety cohort for non-randomized, open-label, phase I/II trial

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 11, Iss 7 (2023)

Background Up to 20% of patients with non-small cell lung cancer (NSCLC) develop brain metastasis (BM), for which the current standard of care is radiation therapy with or without surgery. There are no prospective data on the safety of stereotactic r

Externí odkaz: https://doaj.org/article/51e050d61d114362ab9f5637b2331ad5

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Akademický článek

Phase 1 study of spinal cord constraint relaxation with single session spine stereotactic radiosurgery in the primary management of patients with inoperable, previously irradiated metastatic epidural spinal cord compression

Autor: Amol J Ghia, Nandita Guha-Thakurta, Juhee Song, Peter Thall, Tina M Briere, Stephen H Settle, Hadley J Sharp, Jing Li, MaryFrances McAleer, Eric L Chang, Claudio E Tatsui, Paul D Brown, Laurence D Rhines

Publikováno v: North American Spine Society Journal, Vol 6, Iss , Pp 100066- (2021)

Background: Patients with previously irradiated metastatic epidural spinal cord compression (MESCC) who are not surgical candidates are at high risk of neurologic deterioration due to disease in the setting of limited treatment options. We seek to es

Externí odkaz: https://doaj.org/article/1648ca4f321543d7ac18e2248bdefc9f

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Akademický článek

Response of treatment-naive brain metastases to stereotactic radiosurgery

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)

Abstract With improvements in survival for patients with metastatic cancer, long-term local control of brain metastases has become an increasingly important clinical priority. While consensus guidelines recommend surgery followed by stereotactic radi

Externí odkaz: https://doaj.org/article/e8e236bc0bdc4fe488f94bae47c605e4

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Definitive Local Consolidative Therapy for Oligometastatic Solid Tumors: Results From the Lead-in Phase of the Randomized Basket Trial EXTEND

Autor: Alexander D. Sherry, Tharakeswara K. Bathala, Suyu Liu, Bryan M. Fellman, Stephen G. Chun, Nikesh Jasani, B. Ashleigh Guadagnolo, Anuja Jhingran, Jay P. Reddy, Paul G. Corn, Amishi Y. Shah, Kelsey W. Kaiser, Amol J. Ghia, Daniel R. Gomez, Chad Tang

Publikováno v: International Journal of Radiation Oncology*Biology*Physics. 114:910-918

The benefit of local consolidative therapy (LCT) for oligometastasis across histologies remains uncertain. EXTernal beam radiation to Eliminate Nominal metastatic Disease (EXTEND; NCT03599765) is a randomized phase 2 basket trial evaluating the effec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f210bcfdce82fa972bbaf61d6a7a872c
https://doi.org/10.1016/j.ijrobp.2022.05.023

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Development and validation of a unifying pre-treatment decision tool for intracranial and extracranial metastasis-directed radiotherapy

Publikováno v: Frontiers in Oncology. 13

BackgroundThough metastasis-directed therapy (MDT) has the potential to improve overall survival (OS), appropriate patient selection remains challenging. We aimed to develop a model predictive of OS to refine patient selection for clinical trials and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1d8583335c4fb63ba50fd1b2b76b4ccb
https://doi.org/10.3389/fonc.2023.1095170

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Cardiac Angiosarcomas

Autor: Andrew J. Bishop, Jing Zheng, Aparna Subramaniam, Amol J. Ghia, Chenyang Wang, Susan L. McGovern, Shreyaskumar Patel, B. Ashleigh Guadagnolo, Devarati Mitra, Ahsan Farooqi, Michael J. Reardon, Betty Kim, Nandita Guha-Thakurta, Jing Li, Vinod Ravi

Publikováno v: Am J Clin Oncol

We evaluated a cohort of patients with cardiac angiosarcomas (CA) who developed brain metastases (BM) to define outcomes and intracranial hemorrhage (IH) risk.We reviewed 26 consecutive patients with BM treated between 1988 and 2020 identified from a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35ac70bd736f837b1a44633b2d99f008
https://doi.org/10.1097/coc.0000000000000913

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Comparison of setup accuracy and efficiency between the Klarity system and BodyFIX system for spine stereotactic body radiation therapy

Autor: Enzhuo Quan, Shane P. Krafft, Tina M. Briere, Marissa J. Vaccarelli, Amol J. Ghia, Andrew J. Bishop, Debra N. Yeboa, Todd A. Swanson, Eun Young Han

Publikováno v: Journal of applied clinical medical physics. 23(11)

Spine stereotactic body radiation therapy (SBRT) uses highly conformal dose distributions and sharp dose gradients to cover targets in proximity to the spinal cord or cauda equina, which requires precise patient positioning and immobilization to deli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae9d5f7deaca2ad059f8075665e8bbdf
https://pubmed.ncbi.nlm.nih.gov/36210179

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A Prospective Study of Conventionally Fractionated Dose Constraints for Re-Irradiation of Primary Brain Tumors in Adults

Autor: Susan L. McGovern, Dershan Luo, Jason Johnson, Kham Nguyen, Jing Li, Mary Frances McAleer, Debra Yeboa, David R. Grosshans, Amol J. Ghia, Caroline Chung, Andrew J. Bishop, Juhee Song, Peter F. Thall, Paul D. Brown, Anita Mahajan

Publikováno v: Practical radiation oncology.

Dose constraints for reirradiation of recurrent primary brain tumors are not well-established. This study was conducted to prospectively evaluate composite dose constraints for conventionally-fractionated brain reirradiation.A single-institution, pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cca23230135eb48704e5bd821d7c0a3f
https://pubmed.ncbi.nlm.nih.gov/36596356

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