Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Amol Dixit"'
Autor:
Amol Dixit, Nitin J. Deshmukh, Shivaji Kandre, Jessy Anthony, Amol Gupte, Julie Bose, M. Mahesh Kumar Reddy, Roda Dalal, Raghuram Anupindi, Pundlik Rambhau Bhagat, Rajiv P. Sharma
Publikováno v:
European Journal of Medicinal Chemistry. 79:203-215
Diacylglycerol acyltransferase 1 (DGAT1) is known to play an important catalytic role in the final step of triglyceride biosynthesis. High fat diet fed DGAT1 knockout mice were resistant to weight gain and exhibited increased insulin and leptin sensi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4aca871d56f5d7abc26a1258d279de52
https://doi.org/10.1016/j.ejmech.2014.03.077
https://doi.org/10.1016/j.ejmech.2014.03.077
Autor:
Usha Ghosh, Smriti Khanna, Asha Kulkarni-Almeida, Ankita Srivastava, Komal Bajaj, Chandrika B-Rao, Prashant Tannu, Ashish P. Keche, Kumar V.S. Nemmani, Pranay Shah, Sandeep Burudkar, Rajiv Sharma, Yogesh Suresh Ahire, H. Sivaramakrishnan, Amol Dixit, Anagha Damre, Nitin J. Deshmukh
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:834-838
We report our attempts at improving the oral efficacy of low-nanomolar inhibitors of xanthine oxidase from isocytosine series through chemical modifications. Our lead compound had earlier shown good in vivo efficacy when administered intraperitoneall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::866072cdc89ac5f3a8aa3b0daba5e338
https://doi.org/10.1016/j.bmcl.2012.11.057
https://doi.org/10.1016/j.bmcl.2012.11.057
Autor:
Rajiv Sharma, Smriti Khanna, Umakant Ashok Bahirat, Asha Kulkarni-Almeida, Pranay Shah, Amol Dixit, Kamlesh V. Katkar, Kumar V.S. Nemmani, Ashish P. Keche, H. Sivaramakrishnan, Vaidehi Korde, Chandrika B-Rao, Ankita Srivastava, Nitin J. Deshmukh, Manoja K. Brahma, Lalit S. Doshi, Usha Ghosh
Publikováno v:
Bioorganic & Medicinal Chemistry. 20:2930-2939
In recent years, xanthine oxidase has emerged as an important target not only for gout but also for cardiovascular and metabolic disorders involving hyperuricemia. Contrary to popular belief, recent clinical trials with uricosurics have demonstrated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f36cd3ab923720ed9f3033ad523d3d5
https://doi.org/10.1016/j.bmc.2012.03.019
https://doi.org/10.1016/j.bmc.2012.03.019
Publikováno v:
Expert Opinion on Investigational Drugs. 19:489-512
PPARgamma full agonists (pioglitazone and rosiglitazone) are the mainstay drugs for the treatment of type 2 diabetes; however, mechanism-based side effects have limited their full therapeutic potential. In recent years, much progress has been achieve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91b9452d901c11f9d55675597fef4886
https://doi.org/10.1517/13543781003640169
https://doi.org/10.1517/13543781003640169
Autor:
Sufyan G. Sayyed, Rathinasabapathy Anandharajan, Muralidhara Padigaru, Anagha Damre, Prakash G. Chandak, Ravindra Dattatraya Gupte, Amol Dixit, Manoja K. Brahma, Somesh Sharma, Kumar V.S. Nemmani, Jaspreet Suthar, Nitin J. Deshmukh, Lalit S. Doshi, Pooja Dixit
Publikováno v:
Metabolism. 58:1503-1516
Insulin resistance is central to the pathogenesis of type 2 diabetes mellitus. Previous studies have demonstrated that compounds that cause adipogenesis and improve glucose uptake in 3T3-L1 cells are potential insulin sensitizers. Therefore, we evalu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2edc5d69f126b4c787c7e9d356a7bed7
https://doi.org/10.1016/j.metabol.2009.04.036
https://doi.org/10.1016/j.metabol.2009.04.036
Autor:
Lalit S. Doshi, Kumar V.S. Nemmani, Amol Dixit, Nitin J. Deshmukh, Manoja K. Brahma, Amol Gupte, Kishorkumar Shivajirao Kadam, Anagha Damre, Shaila Srinivasan, Tandra Guha, Shivaji Kandre, Rajiv Sharma, Ravindra Dnyandev Jadhav, M. Mahesh Kumar Reddy, Jayendra Devle
Publikováno v:
European journal of medicinal chemistry. 65
Biphenyl carboxylic acids, exemplified by compound 5, are known potent inhibitors of diacylglycerol acyltransferase, DGAT1, an enzyme involved in the final committed step of triglyceride biosynthesis. We have synthesized and evaluated 2-phenylthiazol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01b0da61e4fa3668e35be9fd9f58c722
https://pubmed.ncbi.nlm.nih.gov/23735282
https://pubmed.ncbi.nlm.nih.gov/23735282
Autor:
Komal Bajaj, Lalit S. Doshi, Rajiv Sharma, Prashant Tannu, Ankita Srivastava, Nitin J. Deshmukh, Manoja K. Brahma, Avani Desai, Anagha Damre, Smriti Khanna, Sandeep Burudkar, Asha Kulkarni-Almeida, Pranay Shah, Usha Ghosh, Chandrika B-Rao, Ashish P. Keche, Amol Dixit, Kumar V.S. Nemmani, Umakant Ashok Bahirat, H. Sivaramakrishnan
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(24)
Structure-activity relationship studies were carried out for lead generation following structure-guided design approach from an isocytosine scaffold identified earlier for xanthine oxidase inhibition. A 470-fold improvement in in vitro IC(50) was obt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ffce995a86667308764db679b25321b
https://pubmed.ncbi.nlm.nih.gov/23122864
https://pubmed.ncbi.nlm.nih.gov/23122864
Autor:
Nitin J. Deshmukh, H. Sivaramakrishnan, Arno A. Enose, Shaila Srinivasan, Shivaji Kandre, Amol Dixit, Kishorkumar Shivajirao Kadam, Rajiv Sharma, Lalit S. Doshi, M. Mahesh Kumar Reddy, Tandra Guha, Ashok Kumar Gangopadhyay, Ram A. Vishwakarma, Ravindra Dnyandev Jadhav, Amol Gupte, Kumar V.S. Nemmani, Nisha Potdar, Manoja K. Brahma
Publikováno v:
European journal of medicinal chemistry. 54
Diacylglycerol acyltransferase, DGAT1, is a promising target enzyme for obesity due to its involvement in the committed step of triglyceride biosynthesis. Amino biphenyl carboxylic acids, exemplified by compound 4, are known potent inhibitors of hDGA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06b079e65d1764828aa1613a3dd9b730
https://pubmed.ncbi.nlm.nih.gov/22683241
https://pubmed.ncbi.nlm.nih.gov/22683241
Autor:
Hashim F. Motiwala, M. Mahesh Kumar Reddy, Mamta Sharma, Kishorkumar Shivajirao Kadam, Kumar V.S. Nemmani, Shivaji Kandre, Amol Gupte, Amol Dixit, Vishal C. Birar, Ashok Kumar Gangopadhyay, Atish Rodge, Ravindra Dnyandev Jadhav, Nitin J. Deshmukh, Shaila Srinivasan, Ram A. Vishwakarma, Lalit S. Doshi, Manoja K. Brahma, Rajiv Sharma
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(19)
The diacylglycerol acyltransferase enzyme, DGAT1, presents itself as a potential target for obesity as this enzyme is dedicated to the final committed step in triglyceride biosynthesis. Biphenyl ureas, exemplified by compound 4, have been reported to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a5d1d354c68012c2648efd6495b8f2d
https://pubmed.ncbi.nlm.nih.gov/21868220
https://pubmed.ncbi.nlm.nih.gov/21868220
Autor:
Amol Dixit, Prakash G. Chandak, Hashim F. Motiwala, Lalit S. Doshi, Somesh Sharma, Venu Pamidiboina, Sufyan G. Sayyed, Manoja K. Brahma, Kumar V.S. Nemmani
Publikováno v:
Metabolism: clinical and experimental. 58(3)
Recently, several in vitro studies have shown that GPR40 receptor activation by free fatty acids (FFAs) results in glucose-dependent insulin secretion. However, whether GPR40 receptor activation results in glucose-dependent insulin secretion in vivo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::412ac8d12dd4a31693f6b353e004eac4
https://pubmed.ncbi.nlm.nih.gov/19217448
https://pubmed.ncbi.nlm.nih.gov/19217448