Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Amol D. Deshpande"'
Autor:
Rajeshkumar Badange, Mukkanti Khagga, Renny Abraham, Amol D. Deshpande, Nageswararao Muddana, Ramasastri Kambhampati, Vishwottam Kandikere, Ramakrishna Nirogi, Vinaykumar Tiriveedhi, Anil Kashinath Chindhe
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:7431-7435
4-(Piperazin-1-yl methyl)-N1-arylsulfonyl indole derivatives were designed and synthesized as 5-HT6 receptor (5-HT6R) ligands. The lead compound 6a, from this series shows potent in vitro binding affinity, good PK profile, no CYP liabilities and acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e1b04e6c8234289869682ff93ad8c82e
https://doi.org/10.1016/j.bmcl.2012.10.057
https://doi.org/10.1016/j.bmcl.2012.10.057
Autor:
Shinde Anil Karbhari, Narasimha Reddy G. Pamuleti, Kameswara Rao Karturi, Sobhanadri Arepalli, Ramasastri Kambhampati, Prabhakar Kothmirkar, Ramakrishna Nirogi, Amol D. Deshpande
Publikováno v:
Synthetic Communications. 38:2419-2428
A series of novel tetracyclic 6-thia-5a-aza-acephenanthrylene derivatives 7 were synthesized by rigidization of the arylsulfonyl/carbonyl/methyl moiety through C7 of indole, which was achieved under Heck conditions. The strategy of altering the palla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d6c157816b3b0c8dedd0691785fd9d1a
https://doi.org/10.1080/00397910802139205
https://doi.org/10.1080/00397910802139205
Autor:
Ramakrishna Nirogi, Amol D. Deshpande, Prabhakar Kothmirkar, Vijay Benade, Renny Abraham, Medapati Rajesh Babu, Gopinadh Bhyrapuneni, Nageswara Rao Muddana, Vishwottam Kandikere, Pradeep Jayarajan, Ravichandra Bhadravathi Vedamurthy, Raghava Chowdary Palacharla, Vinod Kumar Goyal
Publikováno v:
Alzheimer's & Dementia. 9
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d7ef5633924c531e32fc850b4bd277c
https://doi.org/10.1016/j.jalz.2013.05.1750
https://doi.org/10.1016/j.jalz.2013.05.1750
Autor:
Ramakrishna V S, Nirogi, Rajeshkumar, Badange, Ramasastri, Kambhampati, Anil, Chindhe, Amol D, Deshpande, Vinaykumar, Tiriveedhi, Vishwottam, Kandikere, Nageswararao, Muddana, Renny, Abraham, Mukkanti, Khagga
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(24)
4-(Piperazin-1-yl methyl)-N(1)-arylsulfonyl indole derivatives were designed and synthesized as 5-HT(6) receptor (5-HT(6)R) ligands. The lead compound 6a, from this series shows potent in vitro binding affinity, good PK profile, no CYP liabilities an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7b7d49382f7f31d10609d963b717966a
https://pubmed.ncbi.nlm.nih.gov/23141912
https://pubmed.ncbi.nlm.nih.gov/23141912
Autor:
Saravana Kumar Marimuthu, Anil Shinde, Arunkumar Manoharan, Swayam Sampurna Mohanty, Rama Mohan Garikapati, Nageswararao Muddana, Mohammed Abdul Faheem, Abinash Das, Devender Reddy Ajjala, Shantaveer Irappanavar, Dhanalakshmi Shanmuganathan, Vishwottam Kandikere, Ramasastri Kambhampati, Venkat Reddy Mekala, Ramakrishna Nirogi, Amol D. Deshpande, Inderjeet Singh Bhatia, Kancharla Baburao, Ramoji Kosuru
Publikováno v:
Alzheimer's & Dementia. 8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fbb7bf4e815fe1616e0b1b70f62256fb
https://doi.org/10.1016/j.jalz.2012.05.1940
https://doi.org/10.1016/j.jalz.2012.05.1940
Autor:
Ramasastri Kambhampati, Pramod Kumar Dubey, Amol D. Deshpande, Parandhama Gudla, Sobhanadri Arepalli, Prabhakar Kothmirkar, Narasimhareddy P Gangadasari, Adireddy Dwarampudi, Anil Kashinath Chindhe, Ramakrishna Nirogi, Thrinath Reddy Bandyala, Jagadishbabu Konda, Shinde Anil Karbhari
Publikováno v:
Journal of enzyme inhibition and medicinal chemistry. 27(3)
5-Hydroxytryptamine 6 receptors (5-HT(6)R) are being perceived as the possible target for treatment of cognitive disorders as well as obesity. The present article deals with the design, synthesis, in vitro binding and structure-activity relationship
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e20d84a9eb074e7f64e677a39055d803
https://pubmed.ncbi.nlm.nih.gov/21774748
https://pubmed.ncbi.nlm.nih.gov/21774748
Autor:
Nageswararao Muddana, Swayam Sampurna Mohanty, Ganesh Budige, Kancharla Baburao, Mohammed Abdul Faheem, Ram Mohan Garikapati, Ramakrishna Nirogi, Anil Shinde, Vishwottam Kandikere, Sugin Lal Jabaris, Pradeep Jayarajan, Medapati Rajesh Babu, Ramanatha Saralaya, Ishtiyaque Ahmad, Namala Rambabu, Dhanalakshmi Shanmuganathan, Venkat Reddy Mekala, Amol D. Deshpande
Publikováno v:
Alzheimer's & Dementia. 7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e5bd18b17149bdea6cf83e4637687326
https://doi.org/10.1016/j.jalz.2011.05.2282
https://doi.org/10.1016/j.jalz.2011.05.2282
Autor:
Laxman Kota, Amol D. Deshpande, Shinde Anil Karbhari, Ramakrishna Nirogi, Ishtiyaque Ahmad, P. K. Dubey, Anand V. Daulatabad, Pradeep Jayarajan, Rajesh Kumar Badange, Ramasastri Kambhampati, Vishwottam Kandikere
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(1)
N1-Arylsulfonyl-3-piperazinyl indole derivatives were designed and identified as a novel class of 5-HT6 receptors ligands. All the compounds have high affinity and antagonist activity towards 5-HT6 receptor. The compound 7a (Ki = 3.4 nM, functional a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f2e518f6055bef9f7b8a83ab237c0f2
https://pubmed.ncbi.nlm.nih.gov/21134749
https://pubmed.ncbi.nlm.nih.gov/21134749
Autor:
Vishwottam Kandikere, Shinde Anil Karbhari, Vijay Marshall, Dhanalakshmi Shanmuganathan, Pradeep Jayarajan, Rama Moham Garikapati, Ramakrishna Nirogi, Dwarampudi Adi Reddy, Amol D. Deshpande, Gopinadh Bhyrapuneni, Nageshwara Rao Muddana, Ishtiyaque Ahmad
Publikováno v:
Alzheimer's & Dementia. 6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::38c577995c48336139a98910633d2251
https://doi.org/10.1016/j.jalz.2010.05.1917
https://doi.org/10.1016/j.jalz.2010.05.1917
Autor:
Jagadish Babu Konda, Ramakrishna Nirogi, Shinde Anil Karbhari, Sobhanadri Arepalli, Ramasastri Kambhampati, Trinathreddy Bandyala, Pramod Kumar Dubey, Narasimhareddy G. Pamuleti, Amol D. Deshpande, Prabhakar Kothmirkar
The exclusive distribution of 5-HT6 receptors in the brain regions associated with learning and memory makes it an ideal target for cognitive disorders. A novel series of 5-piperazinyl methyl-N 1-aryl sulfonyl indoles were designed and synthesized as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca262c39e23ced82d76238cf91c68a96
https://europepmc.org/articles/PMC4007800/
https://europepmc.org/articles/PMC4007800/
