Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Amol A. Raje"'
Autor:
Ashutosh Gavali, Amol A. Raje, Vallabh Mahajan, Ashwani Gaur, Vishal V Pathade, Kaushal Joshi, Vishwottam Kandikere
Publikováno v:
Xenobiotica. 50:663-669
Pharmacokinetic studies are an integral part of drug discovery and development. Mice are the commonly used species for pharmacokinetics studies during early discovery studies. Conventionally, composite PK profiles are obtained from mice studies due t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81decb86a995e868dec3f1ab26265b66
https://doi.org/10.1080/00498254.2019.1683259
https://doi.org/10.1080/00498254.2019.1683259
Autor:
Vikram Ramanathan, Ajit R. Gadekar, Rakshit Ameta, Bhavesh D. Patel, Amol A. Raje, Nageswararao Pulakundam
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 174:396-405
A specific liquid chromatography–tandem mass spectrometry (LC-ESI-MS/MS) assay was developed and validated for simultaneous determination of two active metabolites of isosorbide dinitrate (ISDN), namely, isosorbide 2-mononitrate (IS 2-MN) and isoso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cd3fe1f5ff191ae9eb075022a38c572
https://doi.org/10.1016/j.jpba.2019.06.007
https://doi.org/10.1016/j.jpba.2019.06.007
Autor:
Madhu bala, Partha P. Mukhopadhyay, Kasim A. Mookhtiar, Bheemashankar Kulkarni, Nadim S. Shaikh, Amol A. Raje, Dhananjay N. Umrani, Debnath Bhuniya, Prasad Sherkar, Yogesh Munot, Sachin Joshi, Satyanarayan Reddy, Vishwottam Kandikere, Mahendra Lohote, Jitesh P. Iyer, Vijay Jamdar, Rajkanth Petla, Ranganayaki Nagaraj, Ravindra Gavhane, Ashwinkumar V. Meru, Sreekanth R. Rouduri
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 29:2208-2217
Targeting nuclear receptor RORγ is recognized to be beneficial in multiple autoimmune disorders. We disclosed new indole analogues as potent RORγ inverse agonists. RO-2 as one of the potent and orally bioavailable compounds was evaluated in various
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0a67352535118055ef6001475eb59fc
https://doi.org/10.1016/j.bmcl.2019.06.044
https://doi.org/10.1016/j.bmcl.2019.06.044
Autor:
Ashwinkumar V. Meru, Siddhartha De, Debnath Bhuniya, Nadim S. Shaikh, Kasim A. Mookhtiar, Kaushal Joshi, Rashmi Barbhaiya, Vamsi Madgula, Sandeep Bhosale, Amol A. Raje, Rajendra K. Kharul, Dhananjay Joshi, Amol Magdum, Fouzia Begum, Sonalee Athavankar, Hajare Atul Kashinath, Sandip Balwe
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 29:238-243
Conceptual design and modification of urea moiety in chemotype PF-3845/04457845, the bench marking irreversible inhibitor of fatty acid amide hydrolase (FAAH), led to discovery of a novel nicotinamide-based lead 12a having reversible mechanism of act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee8afc28b56fce6740f7cbc39ee182d1
https://doi.org/10.1016/j.bmcl.2018.11.048
https://doi.org/10.1016/j.bmcl.2018.11.048
Autor:
Atul Wavhal, Yogesh Waman, Siddhartha De, Anil M. Deshpande, Manoj Joshi, Sachin Kandalkar, Dinesh A. Barawkar, Amol A. Raje, Venkata P. Palle, Kasim A. Mookhtiar, Ashwini Tambe, Shariq S. Ansari, Parimi Atchuta Ramaiah
Publikováno v:
Bioorganic & Medicinal Chemistry. 25:5799-5819
A series of terminal nonyl chain and nucleobase modified analogues of (+)-EHNA (III) were synthesized and evaluated for their ability to inhibit adenosine deaminase (ADA). The constrained carbon analogues of (+)-EHNA, 7a-7h, 10a-c, 12, 13, 14 and 17a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c08c834ecbb90ab20b8a462fd69e7cbd
https://doi.org/10.1016/j.bmc.2017.09.015
https://doi.org/10.1016/j.bmc.2017.09.015
Autor:
Amol Magdum, Anil Panmand, Ravi K. Bhamidipati, Amol A. Raje, Vamsi Madgula, Ganesh Bhat, Meena Patel, Sreekanth R. Rouduri, Siddhartha De, Yogesh D. Shejul, Rajesh Bonagiri, Vandna Prasad, Anita Chugh, Ashwinkumar V. Meru, Vidya Ramdas, Sujay Basu, Dinesh A. Barawkar, Venkata P. Palle, Azfar Quraishi, Narayanan Hariharan, Sumit Chaudhary, Kasim A. Mookhtiar, Indraneel Ghosh, Minakshi Naykodi, K. Kashinath, Sachin Thorat
Publikováno v:
ACS Medicinal Chemistry Letters. 8:835-840
Adenosine A2A receptor (A2AAdoR) antagonism is a nondopaminergic approach to Parkinson's disease treatment that is under development. Earlier we had reported the therapeutic potential of 7-methoxy-4-morpholino-benzothiazole derivatives as A2AAdoR ant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b859d65370dfe38949bf73f0a518820a
https://doi.org/10.1021/acsmedchemlett.7b00175
https://doi.org/10.1021/acsmedchemlett.7b00175
Autor:
Kasim A. Mookhtiar, Anita Chugh, Rahul D. Kaduskar, Siddhartha De, Dhananjay N. Umrani, Debnath Bhuniya, Keshav Naik, Santosh Kurhade, Prasad Shitole, Balasaheb Kobal, Pratima Patil, Amol A. Raje, Sandhya Chaturvedi Joshi, Vamsi Madgula, Vaibhav Jain, Satyanarayana Reddy, Vyavahare Vinod, Suhas Tambe, Venkata P. Palle, Jayasagar Gundu, Ganesh Bhat, Bhavesh Dave, Anil M. Deshpande, Sachin Kandalkar, Sujay Basu
Publikováno v:
European Journal of Medicinal Chemistry. 133:268-286
Glucokinase activators (GKAs) are among the emerging drug candidates for the treatment of type 2 diabetes (T2D). Despite effective blood glucose lowering in clinical trials, many pan-GKAs "acting both in pancreas and liver" have been discontinued fro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cc407021454742cbb5545882542a7f5
https://doi.org/10.1016/j.ejmech.2017.03.042
https://doi.org/10.1016/j.ejmech.2017.03.042
Autor:
Salunkhe Videsh, Madhu bala, Avinash Dhanave, Tanaji Mengawade, Vamsi Madgula, Mahesh Thakkar, Keshav Naik, Bheemashankar Kulkarni, Rahul D. Kaduskar, Dhananjay N. Umrani, Santosh Kurhade, Sachin Joshi, Amit Bhalerao, Sreekanth R. Rouduri, Vishal V Pathade, Rajkanth Petla, Swagatam Ray, Narayanan Hariharan, Kasim A. Mookhtiar, Satheesh Veerappa Avaragolla, Debnath Bhuniya, Jagadeesh Mavinahalli, Ashwini Tambe, Vaibhav Jain, Siddhartha De, Amol A. Raje, Ahmed Nadeem
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:1867-1873
In a pursuit to identify reversible and selective BTK inhibitors, two series based on 7H-pyrrolo[2,3-d]pyrimidine and 1H-pyrrolo[2,3-b]pyridine as the hinge binding core, have been identified. Structure activity relationship (SAR) exploration led to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59344b4bbaa9f604c182b2a0a030bcea
https://doi.org/10.1016/j.bmcl.2017.02.026
https://doi.org/10.1016/j.bmcl.2017.02.026
Autor:
Amol A. Raje, Bhavesh D. Patel, Rakshit Ameta, Ajit R. Gadekar, Rajesh Alamanda, Nageswararao Palakundam
Publikováno v:
Journal of pharmaceutical and biomedical analysis. 172
Bepridil is potent inhibitor of Na+, K+ and Ca+ channel in cardiomyocytes. It has demonstrated strong antianginal effect with type I antiarrhythmic and with minimum antihypertensive therapeutic effect. Till date, a specific LC–MS/MS method to quant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f384dab6faeeec6831149915cbe41f7
https://pubmed.ncbi.nlm.nih.gov/31029800
https://pubmed.ncbi.nlm.nih.gov/31029800
Autor:
Ramana Jinugu, Amol A. Raje, Vamsi Madgula, Ashwini Tambe, Chandragouda R. Patil, Kasim A. Mookhtiar, Ashwani Gaur, Vishwottam Kandikere, Vishal V Pathade, Vallabh Mahajan, Radni D Deshpande, Kaushal Joshi
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 48(12)
1. Budesonide, a potent topical corticosteroid, reported to have low oral bioavailability in mice, rat, dog and human due to rapid first pass metabolism. However, there is insufficient information available in literature regarding the role of intesti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb0c3dfe08ae67c19b171b49068adc21
https://pubmed.ncbi.nlm.nih.gov/29165024
https://pubmed.ncbi.nlm.nih.gov/29165024