Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Amol, Ugale"'
Autor:
Amol Ugale, Gudmundur L. Norddahl, Martin Wahlestedt, Petter Säwén, Pekka Jaako, Cornelis Jan Pronk, Shamit Soneji, Jörg Cammenga, David Bryder
Publikováno v:
Cell Reports, Vol 9, Iss 4, Pp 1246-1255 (2014)
Studies of developmental pathways of hematopoietic stem cells (HSCs) have defined lineage relationships throughout the blood system. This is relevant to acute myeloid leukemia (AML), where aggressiveness and therapeutic responsiveness can be influenc
Externí odkaz:
https://doaj.org/article/c4741b7b55ce4fbab0fbd79d05e03d44
Autor:
Ouyang, Yuan, Amol, Ugale, Tommaso, de Marchi, Vimala, Anthonydhason, Anna, Konturek-Ciesla, Haixia, Wan, Mohamed, Eldeeb, Caroline, Drabe, Maria, Jassinskaja, Jenny, Hansson, Isabel, Hidalgo, Talia, Velasco-Hernandez, Jörg, Cammenga, Jeffrey A, Magee, Emma, Niméus, David, Bryder
Publikováno v:
Science advances. 8(16)
Acute myeloid leukemia (AML) arises when leukemia-initiating cells, defined by a primary genetic lesion, acquire subsequent molecular changes whose cumulative effects bypass tumor suppression. The changes that underlie AML pathogenesis not only provi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::66fd0fb53c08f7631a0e5076964cafc8
https://pubmed.ncbi.nlm.nih.gov/35442741
https://pubmed.ncbi.nlm.nih.gov/35442741
Publikováno v:
Experimental Hematology. 111:S139-S140
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7874c6f14008b58f8236f94342556679
https://doi.org/10.1016/j.exphem.2022.07.246
https://doi.org/10.1016/j.exphem.2022.07.246
Autor:
Amol Ugale, Mohamed Eldeeb, Göran Karlsson, David Bryder, Shamit Soneji, Parashar Dhapola, Eva Erlandsson, R. Olofzon
Single-cell transcriptomics facilitates innovative approaches to define and identify cell types within tissues and cell populations. An emerging interest in the cancer field is to assess the heterogeneity of transformed cells, including the identific
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8e9188160c0481d05709d8f41e4e5ee5
https://doi.org/10.1101/2020.09.30.321216
https://doi.org/10.1101/2020.09.30.321216
Autor:
David Bryder, Gudmundur L. Norddahl, Martin Wahlestedt, Amol Ugale, Petter Säwén, Monika Dudenhöffer-Pfeifer
Publikováno v:
Oncogene. 36:3207-3212
Translocations involving the mixed lineage leukemia-1 are recurrent events in acute leukemia and associate with lymphoid (ALL), myeloid (AML) or mixed lineage (MLL) subtypes. Despite an association with ALL in humans, murine MLL fusion models are per
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::926c7a34ea92e0eabf80e689f2169d32
https://doi.org/10.1038/onc.2016.470
https://doi.org/10.1038/onc.2016.470
Autor:
Olli Lohi, Jae-Woong Lee, Shai Izraeli, Mark A. Murakami, Seyedmehdi Shojaee, Teresa Sadras, Christian Hurtz, David M. Weinstock, Markus Müschen, Merja Heinäniemi, Kohei Kume, Petri Pölönen, Amol Ugale, Arun P. Wiita, Lai N. Chan, Kadriye Nehir Cosgun, Huimin Geng, Rebecca Caesar
Publikováno v:
Blood. 134:3944-3944
Background and significance: Normal B-cells constantly exchange information with their environment and depend on external cues for proliferation and survival that engage multiple divergent pathways (e.g. cytokine receptors; B-cell receptor, BCR). The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5e771ef5c7b43b3c2657104ecde728ad
https://doi.org/10.1182/blood-2019-130774
https://doi.org/10.1182/blood-2019-130774
Publikováno v:
Experimental Hematology. 76:S63
Single-cell transcriptomics (scRNA-Seq) has accelerated the investigation of hematopoietic differentiation. Based on scRNA-Seq data, more refined models of lineage determination in stem- and progenitor cells are now available. Despite such advances,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87a7fd08d7c0a14470b1ec84db3d92ce
https://doi.org/10.1016/j.exphem.2019.06.349
https://doi.org/10.1016/j.exphem.2019.06.349
Autor:
Amol Ugale, Gudmundur L. Norddahl, David Bryder, Gerd Sten, Martin Wahlestedt, Mikael Sigvardsson, Jens M. Nygren, Cornelis J.H. Pronk
Publikováno v:
Cell Stem Cell. 8(5):499-510
SummarySomatic stem cells mediate tissue maintenance for the lifetime of an organism. Despite the well-established longevity that is a prerequisite for such function, accumulating data argue for compromised stem cell function with age. Identifying th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c2369cc83db07fa33f8de1605f69748
Autor:
Martin Wahlestedt, Jörg Cammenga, Pekka Jaako, Talia Velasco-Hernandez, David Bryder, Amol Ugale, Mikael S. Lindström
Publikováno v:
Leukemia. 31(1)
Mutations resulting in constitutive activation of signaling pathways that regulate ribosome biogenesis are among the most common genetic events in acute myeloid leukemia (AML). However, whether ribosome biogenesis presents as a therapeutic target to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf10c80871aad7fa737031d204189fb9
https://pubmed.ncbi.nlm.nih.gov/27256803
https://pubmed.ncbi.nlm.nih.gov/27256803
Publikováno v:
BMC Bioinformatics
BMC Bioinformatics; 16, no 320 (2015)
BMC Bioinformatics; 16, no 320 (2015)
Background: Single cell gene expression assays have become a powerful tool with which to dissect heterogeneous populations. While methods and software exist to interrogate such data, what has been lacking is a unified solution combining analysis and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::678e106e756d13e317a92b8c26574a8b
https://doi.org/10.1186/s12859-015-0757-z
https://doi.org/10.1186/s12859-015-0757-z