Selection analysis identifies unusual clustered mutational changes in Omicron lineage BA.1 that likely impact Spike function

Autor: Martin, DP, Lytras, S, Lucaci, AG, Maier, W, Grüning, B, Shank, SD, Weaver, S, MacLean, OA, Orton, RJ, Lemey, P, Boni, MF, Tegally, H, Harkins, G, Scheepers, C, Bhiman, JN, Everatt, J, Amoako, DG, San, JE, Giandhari, J, Sigal, A, NGS-SA, Williamson, C, Hsiao, N-Y, Von Gottberg, A, De Klerk, A, Shafer, RW, Robertson, DL, Wilkinson, RJ, Sewell, BT, Lessells, R, Nekrutenko, A, Greaney, AJ, Starr, TN, Bloom, JD, Murrell, B, Wilkinson, E, Gupta, RK, De Oliveira, T, Kosakovsky Pond, SL

Among the 30 non-synonymous nucleotide substitutions in the Omicron S-gene are 13 that have only rarely been seen in other SARS-CoV-2 sequences. These mutations cluster within three functionally important regions of the S-gene at sites that will like

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1032::48b41e8bc4c0df4e4d9b461e02b4bbb2
http://hdl.handle.net/10044/1/96372

Genomic Characterization of Methicillin-Resistant and Methicillin-Susceptible Staphylococcus aureus Implicated in Bloodstream Infections, KwaZulu-Natal, South Africa: A Pilot Study.

Autor: Hetsa BA; Antimicrobial Research Unit, College of Health Sciences, University of KwaZulu-Natal, Durban 4000, South Africa., Asante J; Antimicrobial Research Unit, College of Health Sciences, University of KwaZulu-Natal, Durban 4000, South Africa.; School of Pharmacy and Pharmaceutical Sciences, University of Cape Coast, PMB, Cape Coast, Ghana., Mbanga J; Antimicrobial Research Unit, College of Health Sciences, University of KwaZulu-Natal, Durban 4000, South Africa.; Department of Applied Biology & Biochemistry, National University of Science and Technology, Corner Cecil Avenue & Gwanda Road, Bulawayo 263, Zimbabwe., Ismail A; Sequencing Core Facility, National Institute for Communicable Diseases, Division of the National Health Laboratory Service, Johannesburg 2193, South Africa.; Department of Biochemistry and Microbiology, Faculty of Science, Engineering and Agriculture, University of Venda, Thohoyandou 0950, South Africa., Abia ALK; Antimicrobial Research Unit, College of Health Sciences, University of KwaZulu-Natal, Durban 4000, South Africa., Amoako DG; Antimicrobial Research Unit, College of Health Sciences, University of KwaZulu-Natal, Durban 4000, South Africa.; Department of Pathobiology, University of Guelph, Guelph, ON N1G 2W1, Canada., Essack SY; Antimicrobial Research Unit, College of Health Sciences, University of KwaZulu-Natal, Durban 4000, South Africa.; School of Pharmacy, University of Jordan, Amman 11942, Jordan.

Publikováno v: Antibiotics (Basel, Switzerland) [Antibiotics (Basel)] 2024 Aug 23; Vol. 13 (9). Date of Electronic Publication: 2024 Aug 23.

SARS-CoV-2 BA.4/5 infection triggers more cross-reactive FcγRIIIa signaling and neutralization than BA.1, in the context of hybrid immunity.

Autor: Richardson SI; SAMRC Antibody Immunity Research Unit, School of Pathology, University of the Witwatersrand, Johannesburg, South Africa.; National Institute for Communicable Diseases of the National Health Laboratory Services, Johannesburg, South Africa., Mzindle N; SAMRC Antibody Immunity Research Unit, School of Pathology, University of the Witwatersrand, Johannesburg, South Africa.; National Institute for Communicable Diseases of the National Health Laboratory Services, Johannesburg, South Africa., Motlou T; SAMRC Antibody Immunity Research Unit, School of Pathology, University of the Witwatersrand, Johannesburg, South Africa.; National Institute for Communicable Diseases of the National Health Laboratory Services, Johannesburg, South Africa., Manamela NP; SAMRC Antibody Immunity Research Unit, School of Pathology, University of the Witwatersrand, Johannesburg, South Africa.; National Institute for Communicable Diseases of the National Health Laboratory Services, Johannesburg, South Africa., van der Mescht MA; Department of Immunology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa., Lambson BE; SAMRC Antibody Immunity Research Unit, School of Pathology, University of the Witwatersrand, Johannesburg, South Africa.; National Institute for Communicable Diseases of the National Health Laboratory Services, Johannesburg, South Africa., Everatt J; SAMRC Antibody Immunity Research Unit, School of Pathology, University of the Witwatersrand, Johannesburg, South Africa., Amoako DG; SAMRC Antibody Immunity Research Unit, School of Pathology, University of the Witwatersrand, Johannesburg, South Africa.; School of Health Sciences, College of Health Sciences, University of KwaZulu-Natal, KwaZulu-Natal, South Africa., Balla S; SAMRC Antibody Immunity Research Unit, School of Pathology, University of the Witwatersrand, Johannesburg, South Africa.; National Institute for Communicable Diseases of the National Health Laboratory Services, Johannesburg, South Africa., von Gottberg A; SAMRC Antibody Immunity Research Unit, School of Pathology, University of the Witwatersrand, Johannesburg, South Africa.; School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa., Wolter N; SAMRC Antibody Immunity Research Unit, School of Pathology, University of the Witwatersrand, Johannesburg, South Africa.; School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa., de Beer Z; Tshwane District Hospital, Pretoria, South Africa., de Villiers TR; Tshwane District Hospital, Pretoria, South Africa., Bodenstein A; Tshwane District Hospital, Pretoria, South Africa., van den Berg G; Tshwane District Hospital, Pretoria, South Africa., Abdullah F; Division for Infectious Diseases, Department of Internal Medicine, Steve Biko Academic Hospital and University of Pretoria, Pretoria, South Africa., Rossouw TM; Department of Immunology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.; Division for Infectious Diseases, Department of Internal Medicine, Steve Biko Academic Hospital and University of Pretoria, Pretoria, South Africa., Boswell MT; Division for Infectious Diseases, Department of Internal Medicine, Steve Biko Academic Hospital and University of Pretoria, Pretoria, South Africa., Ueckermann V; Division for Infectious Diseases, Department of Internal Medicine, Steve Biko Academic Hospital and University of Pretoria, Pretoria, South Africa., Bhiman JN; SAMRC Antibody Immunity Research Unit, School of Pathology, University of the Witwatersrand, Johannesburg, South Africa.; National Institute for Communicable Diseases of the National Health Laboratory Services, Johannesburg, South Africa., Moore PL; SAMRC Antibody Immunity Research Unit, School of Pathology, University of the Witwatersrand, Johannesburg, South Africa.; National Institute for Communicable Diseases of the National Health Laboratory Services, Johannesburg, South Africa.; Centre for the AIDS Programme of Research in South Africa, Durban, South Africa.

Publikováno v: Journal of virology [J Virol] 2024 Jul 23; Vol. 98 (7), pp. e0067824. Date of Electronic Publication: 2024 Jul 02.

Antibacterial, Resistance Modulation, Anti-Biofilm Formation, and Efflux Pump Inhibition Properties of Loeseneriella africana (Willd.) N. Halle (Celastraceae) Stem Extract and Its Constituents.

Autor: Anokwah D; School of Pharmacy and Pharmaceutical Sciences, College of Health and Allied Sciences, University of Cape Coast, PMB, Cape Coast, Ghana., Asante-Kwatia E; Department of Pharmacognosy, Faculty of Pharmacy and Pharmaceutical Sciences, Kwame Nkrumah University of Science and Technology, PMB, Kumasi, Ghana., Asante J; School of Pharmacy and Pharmaceutical Sciences, College of Health and Allied Sciences, University of Cape Coast, PMB, Cape Coast, Ghana., Obeng-Mensah D; School of Pharmacy and Pharmaceutical Sciences, College of Health and Allied Sciences, University of Cape Coast, PMB, Cape Coast, Ghana., Danquah CA; Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, Kwame Nkrumah University of Science and Technology, PMB, Kumasi, Ghana., Amponsah IK; Department of Pharmacognosy, Faculty of Pharmacy and Pharmaceutical Sciences, Kwame Nkrumah University of Science and Technology, PMB, Kumasi, Ghana., Ameyaw EO; School of Pharmacy and Pharmaceutical Sciences, College of Health and Allied Sciences, University of Cape Coast, PMB, Cape Coast, Ghana., Biney RP; School of Pharmacy and Pharmaceutical Sciences, College of Health and Allied Sciences, University of Cape Coast, PMB, Cape Coast, Ghana., Obese E; School of Pharmacy and Pharmaceutical Sciences, College of Health and Allied Sciences, University of Cape Coast, PMB, Cape Coast, Ghana., Oberer L; Novartis Institutes for BioMedical Research, CH-4056 Basel, Switzerland., Amoako DG; Antimicrobial Research Unit, College of Health Sciences, University of KwaZulu-Natal, Durban 4001, South Africa., Abia ALK; Antimicrobial Research Unit, College of Health Sciences, University of KwaZulu-Natal, Durban 4001, South Africa.; Environmental Research Foundation, Westville 3630, South Africa., Mensah AY; Department of Pharmacognosy, Faculty of Pharmacy and Pharmaceutical Sciences, Kwame Nkrumah University of Science and Technology, PMB, Kumasi, Ghana.

Publikováno v: Microorganisms [Microorganisms] 2023 Dec 19; Vol. 12 (1). Date of Electronic Publication: 2023 Dec 19.

Multidrug-resistant Gram-negative bacterial colonization in patients, carriage by healthcare workers and contamination of hospital environments in Ghana.

Autor: Asare Yeboah EE; Antimicrobial Research Unit, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa; Department of Pharmaceutical Sciences, School of Pharmacy, Central University, Miotso, Ghana. Electronic address: esteyram@gmail.com., Agyepong N; Department of Pharmaceutical Sciences, Sunyani Technical University, Sunyani, Ghana., Mbanga J; Antimicrobial Research Unit, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa; National University of Science and Technology, Department of Applied Biology & Biochemistry, P Bag AC939, Bulawayo, Zimbabwe., Amoako DG; Antimicrobial Research Unit, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa; Department of Integrative Biology and Bioinformatics, University of Guelph, Ontario, Canada., Abia ALK; Antimicrobial Research Unit, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa; Environmental Research Foundation, Westville 3630, South Africa., Owusu-Ofori A; Department of Clinical Microbiology, School of Medicine and Dentistry, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana; Clinical Microbiology Unit, Laboratory Services Directorate, Komfo Anokye Teaching Hospital, Kumasi, Ghana., Essack SY; Antimicrobial Research Unit, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa.

Publikováno v: Journal of infection and public health [J Infect Public Health] 2023 Dec; Vol. 16 Suppl 1, pp. 2-8. Date of Electronic Publication: 2023 Nov 02.