Zobrazeno 1 - 10
of 200
pro vyhledávání: '"Amnon HIZI"'
Publikováno v:
PLoS ONE, Vol 14, Iss 1, p e0211111 (2019)
HIV-1 is the causative agent of AIDS (Autoimmune Deficiency Syndrome). HIV-1 infection results in systemic CD4+ T cell depletion, thereby impairing cell-mediated immunity. MicroRNAs are short (~22 nucleotides long), endogenous single-stranded RNA mol
Externí odkaz:
https://doaj.org/article/51216cdbe21443f2bff27d79ff79bb21
Publikováno v:
Mitochondrion. 58:200-212
Mitochondrial RNA degradation plays an important role in maintenance of the mitochondria genetic integrity. Mitochondrial localization of p53 was observed in non-stressed and stressed cells. p53, as an RNA-binding protein, exerts 3'→5' exoribonucle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::459f6962182f50d0d7c73c8f050ac0cd
https://doi.org/10.1016/j.mito.2021.03.007
https://doi.org/10.1016/j.mito.2021.03.007
Publikováno v:
Journal of Molecular Medicine. 98:437-449
The onco-suppressor p53 protein plays also an important role in the control of various aspects of health and disease. p53 levels are low in normal cells and elevated under stress conditions. While low levels of p53 promote tumor formation, overactive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51e95bc03338906ed2a3d03cf7438dd8
https://doi.org/10.1007/s00109-020-01884-0
https://doi.org/10.1007/s00109-020-01884-0
Autor:
Maya Golan, Amnon Hizi, James H. Resau, Neora Yaal-Hahoshen, Hadar Reichman, Iafa Keydar, Ilan Tsarfaty
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 10, Iss 6, Pp 521-533 (2008)
A reverse transcriptase (RT) cDNA, designated HERV-K-T47D-RT, was isolated from a hormonally treated human breast cancer cell line. The protein product putative sequence is 97% identical to the human endogenous HERV-K retroviral sequences. Recombinan
Externí odkaz:
https://doaj.org/article/9f057ede973c4383ae5032a14d66f34b
Publikováno v:
AIDS. 31:343-353
OBJECTIVE(S) HIV-1 reverse transcriptase frequently incorporates ribonucleotides into the proviral DNA in macrophages, but not in lymphocytes. The enzyme exerts an efficient ribonucleotide-terminated primer extension capacity. Furthermore, ribonucleo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f36b5501af02b9f48a9b635adc9537d4
https://doi.org/10.1097/qad.0000000000001339
https://doi.org/10.1097/qad.0000000000001339
Cytoplasmic p53 contributes to the removal of uracils misincorporated by HIV-1 reverse transcriptase
Publikováno v:
Biochemical and biophysical research communications. 497(2)
HIV-1 reverse transcriptase (RT) in the cytoplasm of HIV-infected cells efficiently inserts the non-canonical dUTP into the proviral DNA, and extends the dU-terminated DNA. The misincorporation of dUTP leads to mutagenesis, and uracils can down-regul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::076f80278e8e08287d8f27780b85fd56
https://pubmed.ncbi.nlm.nih.gov/29470985
https://pubmed.ncbi.nlm.nih.gov/29470985
Autor:
Eytan Herzig, Amnon Hizi
Publikováno v:
Virology. 483:13-20
Most currently-used antiretroviral drugs inhibit the reverse-transcriptase (RT) of HIV. The differences between HIV-1 and HIV-2 RTs explain why some of the anti-HIV-1 drugs are not effective against HIV-2. One major difference between the two HIV RTs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c2242fb248eae227cc2ed5056816e26
https://doi.org/10.1016/j.virol.2015.04.018
https://doi.org/10.1016/j.virol.2015.04.018
Publikováno v:
Journal of Virology. 89:8119-8129
The process of reverse transcription (RTN) in retroviruses is essential to the viral life cycle. This key process is catalyzed exclusively by the viral reverse transcriptase (RT) that copies the viral RNA into DNA by its DNA polymerase activity, whil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c7e0c59e29f6e444555c8bd332990ca
https://doi.org/10.1128/jvi.00809-15
https://doi.org/10.1128/jvi.00809-15
Publikováno v:
Journal of Cell Science
MicroRNAs (miRNAs) are short non-coding RNAs that play a central role in the regulation of gene expression by binding to target mRNAs. Several studies have revealed alterations in cellular miRNA profiles following HIV-1 infection, mostly for miRNAs i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44e2e93f4104554ca54ad7e32c447734
http://europepmc.org/articles/PMC4406127
http://europepmc.org/articles/PMC4406127
Publikováno v:
PLoS ONE
PLoS ONE, Vol 14, Iss 1, p e0211111 (2019)
PLoS ONE, Vol 14, Iss 1, p e0211111 (2019)
HIV-1 is the causative agent of AIDS (Autoimmune Deficiency Syndrome). HIV-1 infection results in systemic CD4+ T cell depletion, thereby impairing cell-mediated immunity. MicroRNAs are short (~22 nucleotides long), endogenous single-stranded RNA mol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3d658a1af2ee1744d3874388ed04a6d
https://doi.org/10.1371/journal.pone.0211111
https://doi.org/10.1371/journal.pone.0211111