Zobrazeno 1 - 10
of 249
pro vyhledávání: '"Amnon Altman"'
Autor:
Nikhil Ponnoor Anto, Amitha Muraleedharan, Pulak Ranjan Nath, Zuoming Sun, Chen Keasar, Etta Livneh, Alex Braiman, Amnon Altman, Kok-Fai Kong, Noah Isakov
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Protein kinase C-θ (PKCθ) is a member of the novel PKC subfamily known for its selective and predominant expression in T lymphocytes where it regulates essential functions required for T cell activation and proliferation. Our previous studies provi
Externí odkaz:
https://doaj.org/article/91a28bb9d5b3476481e01935ea58be2a
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
CD45 limits T cell activation, so its exclusion from the T cell immunological synapse is thought to occur as a means to enable TCR signalling. Here the authors use a variety of cellular imaging methods to show that CD45 is indeed excluded from the ti
Externí odkaz:
https://doaj.org/article/7868c43b5a2049ff80ee50c8d4276381
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 9 (2021)
Externí odkaz:
https://doaj.org/article/6b0727518baf4f5588b97fc3c4c8adbd
Autor:
Yujiao He, Zhiguo Yang, Chen-si Zhao, Zhihui Xiao, Yu Gong, Yun-Yi Li, Yiqi Chen, Yunting Du, Dianying Feng, Amnon Altman, Yingqiu Li
Publikováno v:
eLife, Vol 10 (2021)
The nuclear pore complex (NPC) is the sole and selective gateway for nuclear transport, and its dysfunction has been associated with many diseases. The metazoan NPC subcomplex RanBP2, which consists of RanBP2 (Nup358), RanGAP1-SUMO1, and Ubc9, regula
Externí odkaz:
https://doaj.org/article/52a195dd8ec34d5899bfc4bfb33f8a3f
Autor:
Nina K. Serwas, Birgit Hoeger, Rico C. Ardy, Sigrun V. Stulz, Zhenhua Sui, Nima Memaran, Marie Meeths, Ana Krolo, Özlem Yüce Petronczki, Laurène Pfajfer, Tie Z. Hou, Neil Halliday, Elisangela Santos-Valente, Artem Kalinichenko, Alan Kennedy, Emily M. Mace, Malini Mukherjee, Bianca Tesi, Anna Schrempf, Winfried F. Pickl, Joanna I. Loizou, Renate Kain, Bettina Bidmon-Fliegenschnee, Jean-Nicolas Schickel, Salomé Glauzy, Jakob Huemer, Wojciech Garncarz, Elisabeth Salzer, Iro Pierides, Ivan Bilic, Jens Thiel, Peter Priftakis, Pinaki P. Banerjee, Elisabeth Förster-Waldl, David Medgyesi, Wolf-Dietrich Huber, Jordan S. Orange, Eric Meffre, David M. Sansom, Yenan T. Bryceson, Amnon Altman, Kaan Boztug
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
CTLA-4 is critical for balancing protective immunity with self-tolerance. Here the authors identify homozygous DEF6 mutations in patients with severe autoimmunity, one of which received and responds to CTLA-4-Ig, and show that DEF6 is crucial for CTL
Externí odkaz:
https://doaj.org/article/2b28c1d1ae924d86a02c99db5aac2d80
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Follicular helper T (TFH) cells represent a highly specialized CD4+ T cell subpopulation that supports the generation of germinal centers (GC) and provides B cells with critical signals promoting antibody class switching, generation of high affinity
Externí odkaz:
https://doaj.org/article/50413f2b59404891887ffbe295b485e3
Autor:
Nina K. Serwas, Birgit Hoeger, Rico C. Ardy, Sigrun V. Stulz, Zhenhua Sui, Nima Memaran, Marie Meeths, Ana Krolo, Özlem Yüce Petronczki, Laurène Pfajfer, Tie Z. Hou, Neil Halliday, Elisangela Santos-Valente, Artem Kalinichenko, Alan Kennedy, Emily M. Mace, Malini Mukherjee, Bianca Tesi, Anna Schrempf, Winfried F. Pickl, Joanna I. Loizou, Renate Kain, Bettina Bidmon-Fliegenschnee, Jean-Nicolas Schickel, Salomé Glauzy, Jakob Huemer, Wojciech Garncarz, Elisabeth Salzer, Iro Pierides, Ivan Bilic, Jens Thiel, Peter Priftakis, Pinaki P. Banerjee, Elisabeth Förster-Waldl, David Medgyesi, Wolf-Dietrich Huber, Jordan S. Orange, Eric Meffre, David M. Sansom, Yenan T. Bryceson, Amnon Altman, Kaan Boztug
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-2 (2019)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/2ad5e2b7ab8840e49f562084ad81cfe1
Autor:
Rubin N. Joshi, Nadine A. Binai, Francesco Marabita, Zhenhua Sui, Amnon Altman, Albert J. R. Heck, Jesper Tegnér, Angelika Schmidt
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
Regulatory T cells (Tregs) control key events of immune tolerance, primarily by suppression of effector T cells. We previously revealed that Tregs rapidly suppress T cell receptor (TCR)-induced calcium store depletion in conventional CD4+CD25− T ce
Externí odkaz:
https://doaj.org/article/21537957794e4ed690234acc30daf550
Autor:
Marie Hashimoto, Jun-ichi Nagao, Shojiro Ikezaki, Sonoko Tasaki, Ken-ichi Arita-Morioka, Yuka Narita, Tamaki Cho, Kenji Yuasa, Amnon Altman, Yoshihiko Tanaka
Publikováno v:
International Journal of Inflammation, Vol 2017 (2017)
Activation of naive CD4+ T cells results in the development of several distinct subsets of effector Th cells, including Th2 cells that play a pivotal role in allergic inflammation and helminthic infections. SWAP-70-like adapter of T cells (SLAT), als
Externí odkaz:
https://doaj.org/article/2c44c1385b8a4af9a8243f5325fd2f55
