Zobrazeno 1 - 10
of 207
pro vyhledávání: '"Amnon Hoffman"'
Autor:
Alexandra Njegić, Lina Laid, Min Zi, Eleni Maniati, Jun Wang, Alexandru Chelu, Laura Wisniewski, Jenna Hunter, Sukhpal Prehar, Nicholas Stafford, Chaim Gilon, Amnon Hoffman, Michael Weinmüller, Horst Kessler, Elizabeth J. Cartwright, Kairbaan Hodivala-Dilke
Publikováno v:
Journal of Molecular and Cellular Cardiology Plus, Vol 8, Iss , Pp 100069- (2024)
Heart failure remains one of the largest clinical burdens globally, with little to no improvement in the development of disease-eradicating therapeutics. Integrin targeting has been used in the treatment of ocular disease and cancer, but little is kn
Externí odkaz:
https://doaj.org/article/a3900e0a7f874b28bce6fe50725d27f9
Publikováno v:
Molecules, Vol 29, Iss 16, p 3909 (2024)
Purpose: Sodium N-[8-(2-hydroxybenzoyl)amino]caprylate (SNAC) is a well-known penetration enhancer widely used in commercial applications. This study aims to broaden its properties through a novel strategy of converting it into its phenolate salts. T
Externí odkaz:
https://doaj.org/article/e8f6ce197d324e34ae5ea9d258747481
Publikováno v:
Pharmaceutics, Vol 16, Iss 6, p 723 (2024)
We describe the design, synthesis, and activity of a potent thiourea-bridged backbone cyclic peptidomimetic known as Clarstatin, comprising a 5-amino acid sequence (Q/D)1-(R/K)2-X3-X4-A5-(Gln/Asp)1-(Arg/Lys)2-AA3-AA4-Ala5-based on a motif called “s
Externí odkaz:
https://doaj.org/article/834edcd997b149c6b94d34589b80d8ed
Autor:
Majdi Saleem Naamneh, Tatjana Momic, Michal Klazas, Julius Grosche, Johannes A. Eble, Cezary Marcinkiewicz, Netaly Khazanov, Hanoch Senderowitz, Amnon Hoffman, Chaim Gilon, Jehoshua Katzhendler, Philip Lazarovici
Publikováno v:
Pharmaceuticals, Vol 17, Iss 5, p 549 (2024)
To develop peptide drugs targeting integrin receptors, synthetic peptide ligands endowed with well-defined selective binding motifs are necessary. The snake venom KTS-containing disintegrins, which selectively block collagen α1β1 integrin, were use
Externí odkaz:
https://doaj.org/article/a2507c50643f46cfb8943819957681cd
Autor:
Chaim Gilon, Michal Klazas, Adi Lahiani, Adi Schumacher-Klinger, Shira Merzbach, Johnny N. Naoum, Haim Ovadia, Limor Rubin, Susan Cornell-Kennon, Erik M. Schaefer, Jehoshua Katzhendler, Cezary Marcinkiewicz, Amnon Hoffman, Philip Lazarovici
Publikováno v:
JACS Au, Vol 1, Iss 12, Pp 2361-2376 (2021)
Externí odkaz:
https://doaj.org/article/d3a290a521dd414dba56442f22ad6166
Autor:
Alaa Talhami, Avi Swed, Shmuel Hess, Oded Ovadia, Sarit Greenberg, Adi Schumacher-Klinger, David Rosenthal, Deborah E. Shalev, Mattan Hurevich, Philip Lazarovici, Amnon Hoffman, Chaim Gilon
Publikováno v:
Frontiers in Chemistry, Vol 8 (2020)
Painkillers are commonly used medications. Native peptide painkillers suffer from various pharmacological disadvantages, while small molecule painkillers like morphine are highly addictive. We present a general approach aimed to use backbone-cyclizat
Externí odkaz:
https://doaj.org/article/214c0a356de24363ad9340767112adf5
Autor:
Jeetendra Kumar Nag, Hodaya Malka, Shoshana Sedley, Priyanga Appasamy, Tatyana Rudina, Tgst Levi, Amnon Hoffman, Chaim Gilon, Beatrice Uziely, Rachel Bar-Shavit
Publikováno v:
Molecular Cancer Therapeutics. 21:1415-1429
While the role of G-protein–coupled receptors (GPCR) in cancer is acknowledged, their underlying signaling pathways are understudied. Protease-activated receptors (PAR), a subgroup of GPCRs, form a family of four members (PAR1–4) centrally involv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3fcaa5744d55ebaea04c3a61fe4302a
https://doi.org/10.1158/1535-7163.mct-21-0946
https://doi.org/10.1158/1535-7163.mct-21-0946
Supplementary Figure from PH-Binding Motif in PAR4 Oncogene: From Molecular Mechanism to Drug Design
Autor:
Rachel Bar-Shavit, Beatrice Uziely, Chaim Gilon, Amnon Hoffman, Tgst Levi, Tatyana Rudina, Priyanga Appasamy, Shoshana Sedley, Hodaya Malka, Jeetendra Kumar Nag
Supplementary Figure from PH-Binding Motif in PAR4 Oncogene: From Molecular Mechanism to Drug Design
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0453d20132cce1787e1084d5606b5234
https://doi.org/10.1158/1535-7163.22523497
https://doi.org/10.1158/1535-7163.22523497
Autor:
Rachel Bar-Shavit, Beatrice Uziely, Chaim Gilon, Amnon Hoffman, Tgst Levi, Tatyana Rudina, Priyanga Appasamy, Shoshana Sedley, Hodaya Malka, Jeetendra Kumar Nag
Supplementary Table from PH-Binding Motif in PAR4 Oncogene: From Molecular Mechanism to Drug Design
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a76f2d36747c9732a6e06237440834b
https://doi.org/10.1158/1535-7163.22523494
https://doi.org/10.1158/1535-7163.22523494
Autor:
Cezary Marcinkiewicz, Erik Schaefer, Philip Lazarovici, Limor Rubin, Adi Schumacher-Klinger, Haim Ovadia, Adi Lahiani, Jehoshua Katzhendler, Chaim Gilon, Shira Merzbach, Johnny N. Naoum, Amnon Hoffman, Susan Cornell-Kennon, Michal Klazas
Publikováno v:
JACS Au
JACS Au, Vol 1, Iss 12, Pp 2361-2376 (2021)
JACS Au, Vol 1, Iss 12, Pp 2361-2376 (2021)
Integrins α4β1/ α9β1 are important in the pathogenesis and progression of inflammatory and autoimmune diseases by their roles in leukocyte activation and trafficking. Natalizumab, a monoclonal antibody selectively targeting α4β1 integrin and bl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34c48b271b8d3b46b3e3953d8f14206d
http://europepmc.org/articles/PMC8717366
http://europepmc.org/articles/PMC8717366