A high-affinity, bivalent PDZ domain inhibitor complexes PICK1 to alleviate neuropathic pain.

Autor: Christensen NR; Molecular Neuropharmacology and Genetics Laboratory, Department of Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Center for Biopharmaceuticals, Department of Drug Design and Pharmacology, Faculty of Health and Medicine, University of Copenhagen, Copenhagen, Denmark., De Luca M; Molecular Neuropharmacology and Genetics Laboratory, Department of Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Lever MB; Molecular Neuropharmacology and Genetics Laboratory, Department of Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Richner M; Danish Research Institute of Translational Neuroscience (DANDRITE), Nordic-EMBL Partnership for Molecular Medicine, Department of Biomedicine, Aarhus University, Aarhus C, Denmark., Hansen AB; Molecular Neuropharmacology and Genetics Laboratory, Department of Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Noes-Holt G; Molecular Neuropharmacology and Genetics Laboratory, Department of Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Jensen KL; Molecular Neuropharmacology and Genetics Laboratory, Department of Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Rathje M; Molecular Neuropharmacology and Genetics Laboratory, Department of Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Jensen DB; Department of Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Erlendsson S; Structural biology and NMR Laboratory, Department of Biology, University of Copenhagen, Copenhagen, Denmark., Bartling CR; Center for Biopharmaceuticals, Department of Drug Design and Pharmacology, Faculty of Health and Medicine, University of Copenhagen, Copenhagen, Denmark., Ammendrup-Johnsen I; Molecular Neuropharmacology and Genetics Laboratory, Department of Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Pedersen SE; Molecular Neuropharmacology and Genetics Laboratory, Department of Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Schönauer M; Center for Biopharmaceuticals, Department of Drug Design and Pharmacology, Faculty of Health and Medicine, University of Copenhagen, Copenhagen, Denmark., Nissen KB; Center for Biopharmaceuticals, Department of Drug Design and Pharmacology, Faculty of Health and Medicine, University of Copenhagen, Copenhagen, Denmark., Midtgaard SR; Structural Biophysics, Niels Bohr Institute, University of Copenhagen, Copenhagen, Denmark., Teilum K; Structural biology and NMR Laboratory, Department of Biology, University of Copenhagen, Copenhagen, Denmark., Arleth L; Structural Biophysics, Niels Bohr Institute, University of Copenhagen, Copenhagen, Denmark., Sørensen AT; Molecular Neuropharmacology and Genetics Laboratory, Department of Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Bach A; Center for Biopharmaceuticals, Department of Drug Design and Pharmacology, Faculty of Health and Medicine, University of Copenhagen, Copenhagen, Denmark., Strømgaard K; Center for Biopharmaceuticals, Department of Drug Design and Pharmacology, Faculty of Health and Medicine, University of Copenhagen, Copenhagen, Denmark., Meehan CF; Department of Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Vaegter CB; Danish Research Institute of Translational Neuroscience (DANDRITE), Nordic-EMBL Partnership for Molecular Medicine, Department of Biomedicine, Aarhus University, Aarhus C, Denmark., Gether U; Molecular Neuropharmacology and Genetics Laboratory, Department of Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Madsen KL; Molecular Neuropharmacology and Genetics Laboratory, Department of Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Publikováno v: EMBO molecular medicine [EMBO Mol Med] 2020 Jun 08; Vol. 12 (6), pp. e11248. Date of Electronic Publication: 2020 Apr 30.

Impaired Hippocampal Long-Term Potentiation and Memory Deficits upon Haploinsufficiency of MDGA1 Can Be Rescued by Acute Administration of D-Cycloserine.

Autor: Ojima, Daiki¹ (AUTHOR) tada.atsushi@kagawa-u.ac.jp, Tominaga, Yoko² (AUTHOR), Kubota, Takashi³ (AUTHOR) tkubota@kph.bunri-u.ac.jp, Tada, Atsushi¹ (AUTHOR) takahashi.hiroo@kagawa-u.ac.jp, Takahashi, Hiroo¹ (AUTHOR), Kishimoto, Yasushi^3,4 (AUTHOR) y-kishimoto@pharm.teikyo-u.ac.jp, Tominaga, Takashi^2,5 (AUTHOR) tominagat@kph.bunri-u.ac.jp, Yamamoto, Tohru¹ (AUTHOR) tominagat@kph.bunri-u.ac.jp

Publikováno v: International Journal of Molecular Sciences. Sep2024, Vol. 25 Issue 17, p9674. 15p.

An Amphipathic Helix Directs Cellular Membrane Curvature Sensing and Function of the BAR Domain Protein PICK1.

Autor: Herlo R; Molecular Neuropharmacology and Genetics Laboratory, Lundbeck Foundation Center for Biomembranes in Nanomedicine, Department of Neuroscience, Faculty of Health and Medical Sciences, The Panum Institute - Mærsk Tower, University of Copenhagen, 2200 Copenhagen N, Denmark., Lund VK; Molecular Neuropharmacology and Genetics Laboratory, Lundbeck Foundation Center for Biomembranes in Nanomedicine, Department of Neuroscience, Faculty of Health and Medical Sciences, The Panum Institute - Mærsk Tower, University of Copenhagen, 2200 Copenhagen N, Denmark., Lycas MD; Molecular Neuropharmacology and Genetics Laboratory, Lundbeck Foundation Center for Biomembranes in Nanomedicine, Department of Neuroscience, Faculty of Health and Medical Sciences, The Panum Institute - Mærsk Tower, University of Copenhagen, 2200 Copenhagen N, Denmark., Jansen AM; Molecular Neuropharmacology and Genetics Laboratory, Lundbeck Foundation Center for Biomembranes in Nanomedicine, Department of Neuroscience, Faculty of Health and Medical Sciences, The Panum Institute - Mærsk Tower, University of Copenhagen, 2200 Copenhagen N, Denmark., Khelashvili G; Department of Physiology and Biophysics, Weill Cornell Medical College, Cornell University, 1300 York Avenue, New York City, NY 10065, USA., Andersen RC; Molecular Neuropharmacology and Genetics Laboratory, Lundbeck Foundation Center for Biomembranes in Nanomedicine, Department of Neuroscience, Faculty of Health and Medical Sciences, The Panum Institute - Mærsk Tower, University of Copenhagen, 2200 Copenhagen N, Denmark., Bhatia V; Bionanotechnology and Nanomedicine Laboratory, Lundbeck Foundation Center for Biomembranes in Nanomedicine, Department of Chemistry, and Nano-Science Center, University of Copenhagen, 2300 Copenhagen Ø, Denmark., Pedersen TS; Molecular Neuropharmacology and Genetics Laboratory, Lundbeck Foundation Center for Biomembranes in Nanomedicine, Department of Neuroscience, Faculty of Health and Medical Sciences, The Panum Institute - Mærsk Tower, University of Copenhagen, 2200 Copenhagen N, Denmark., Albornoz PBC; Department of Physiology and Biophysics, Weill Cornell Medical College, Cornell University, 1300 York Avenue, New York City, NY 10065, USA., Johner N; Department of Physiology and Biophysics, Weill Cornell Medical College, Cornell University, 1300 York Avenue, New York City, NY 10065, USA., Ammendrup-Johnsen I; Molecular Neuropharmacology and Genetics Laboratory, Lundbeck Foundation Center for Biomembranes in Nanomedicine, Department of Neuroscience, Faculty of Health and Medical Sciences, The Panum Institute - Mærsk Tower, University of Copenhagen, 2200 Copenhagen N, Denmark., Christensen NR; Molecular Neuropharmacology and Genetics Laboratory, Lundbeck Foundation Center for Biomembranes in Nanomedicine, Department of Neuroscience, Faculty of Health and Medical Sciences, The Panum Institute - Mærsk Tower, University of Copenhagen, 2200 Copenhagen N, Denmark., Erlendsson S; Molecular Neuropharmacology and Genetics Laboratory, Lundbeck Foundation Center for Biomembranes in Nanomedicine, Department of Neuroscience, Faculty of Health and Medical Sciences, The Panum Institute - Mærsk Tower, University of Copenhagen, 2200 Copenhagen N, Denmark., Stoklund M; Molecular Neuropharmacology and Genetics Laboratory, Lundbeck Foundation Center for Biomembranes in Nanomedicine, Department of Neuroscience, Faculty of Health and Medical Sciences, The Panum Institute - Mærsk Tower, University of Copenhagen, 2200 Copenhagen N, Denmark., Larsen JB; Bionanotechnology and Nanomedicine Laboratory, Lundbeck Foundation Center for Biomembranes in Nanomedicine, Department of Chemistry, and Nano-Science Center, University of Copenhagen, 2300 Copenhagen Ø, Denmark., Weinstein H; Department of Physiology and Biophysics, Weill Cornell Medical College, Cornell University, 1300 York Avenue, New York City, NY 10065, USA., Kjærulff O; Molecular Neuropharmacology and Genetics Laboratory, Lundbeck Foundation Center for Biomembranes in Nanomedicine, Department of Neuroscience, Faculty of Health and Medical Sciences, The Panum Institute - Mærsk Tower, University of Copenhagen, 2200 Copenhagen N, Denmark., Stamou D; Bionanotechnology and Nanomedicine Laboratory, Lundbeck Foundation Center for Biomembranes in Nanomedicine, Department of Chemistry, and Nano-Science Center, University of Copenhagen, 2300 Copenhagen Ø, Denmark., Gether U; Molecular Neuropharmacology and Genetics Laboratory, Lundbeck Foundation Center for Biomembranes in Nanomedicine, Department of Neuroscience, Faculty of Health and Medical Sciences, The Panum Institute - Mærsk Tower, University of Copenhagen, 2200 Copenhagen N, Denmark. Electronic address: gether@sund.ku.dk., Madsen KL; Molecular Neuropharmacology and Genetics Laboratory, Lundbeck Foundation Center for Biomembranes in Nanomedicine, Department of Neuroscience, Faculty of Health and Medical Sciences, The Panum Institute - Mærsk Tower, University of Copenhagen, 2200 Copenhagen N, Denmark. Electronic address: kennethma@sund.ku.dk.

Publikováno v: Cell reports [Cell Rep] 2018 May 15; Vol. 23 (7), pp. 2056-2069.

The GPRC6A receptor displays constitutive internalization and sorting to the slow recycling pathway.

Autor: Jacobsen SE; From the Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, 2100 Copenhagen, Denmark and., Ammendrup-Johnsen I; Molecular Neuropharmacology Laboratory, Lundbeck Foundation Center for Biomembranes in Nanomedicine, Department of Neuroscience and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark., Jansen AM; Molecular Neuropharmacology Laboratory, Lundbeck Foundation Center for Biomembranes in Nanomedicine, Department of Neuroscience and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark., Gether U; Molecular Neuropharmacology Laboratory, Lundbeck Foundation Center for Biomembranes in Nanomedicine, Department of Neuroscience and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark., Madsen KL; Molecular Neuropharmacology Laboratory, Lundbeck Foundation Center for Biomembranes in Nanomedicine, Department of Neuroscience and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark., Bräuner-Osborne H; From the Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, 2100 Copenhagen, Denmark and hbo@sund.ku.dk.

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2017 Apr 28; Vol. 292 (17), pp. 6910-6926. Date of Electronic Publication: 2017 Mar 09.

Altered Cortical Dynamics and Cognitive Function upon Haploinsufficiency of the Autism-Linked Excitatory Synaptic Suppressor MDGA2.

Autor: Connor SA; Brain Research Centre and Department of Psychiatry, University of British Columbia, Vancouver, BC V6T 2B5, Canada; Brain Research Centre and Department of Medicine, University of British Columbia, Vancouver, BC V6T 2B5, Canada., Ammendrup-Johnsen I; Brain Research Centre and Department of Psychiatry, University of British Columbia, Vancouver, BC V6T 2B5, Canada., Chan AW; Brain Research Centre and Department of Psychiatry, University of British Columbia, Vancouver, BC V6T 2B5, Canada; Brain Research Centre and Department of Medicine, University of British Columbia, Vancouver, BC V6T 2B5, Canada., Kishimoto Y; Department of Neurobiophysics, Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University, Sanuki, Kagawa 769-2101, Japan., Murayama C; Department of Molecular Neurobiology, Faculty of Medicine, Kagawa University, Miki-cho, Kagawa 761-0793, Japan; Laboratory of Neuroscience, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Hokkaido 060-0812, Japan., Kurihara N; Department of Neurobiophysics, Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University, Sanuki, Kagawa 769-2101, Japan., Tada A; Department of Neurobiophysics, Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University, Sanuki, Kagawa 769-2101, Japan., Ge Y; Brain Research Centre and Department of Psychiatry, University of British Columbia, Vancouver, BC V6T 2B5, Canada., Lu H; Brain Research Centre and Department of Psychiatry, University of British Columbia, Vancouver, BC V6T 2B5, Canada., Yan R; Brain Research Centre and Department of Psychiatry, University of British Columbia, Vancouver, BC V6T 2B5, Canada., LeDue JM; Brain Research Centre and Department of Psychiatry, University of British Columbia, Vancouver, BC V6T 2B5, Canada., Matsumoto H; Laboratory of Neuroscience, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Hokkaido 060-0812, Japan., Kiyonari H; Animal Resource Development Unit, RIKEN Center for Developmental Biology, Kobe, Hyogo 650-0047, Japan; Genetic Engineering Team, RIKEN Center for Developmental Biology, Kobe, Hyogo 650-0047, Japan., Kirino Y; Department of Neurobiophysics, Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University, Sanuki, Kagawa 769-2101, Japan., Matsuzaki F; Laboratory for Cell Asymmetry, RIKEN Center for Developmental Biology, Kobe, Hyogo 650-0047, Japan., Suzuki T; Laboratory of Neuroscience, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Hokkaido 060-0812, Japan., Murphy TH; Brain Research Centre and Department of Psychiatry, University of British Columbia, Vancouver, BC V6T 2B5, Canada., Wang YT; Brain Research Centre and Department of Medicine, University of British Columbia, Vancouver, BC V6T 2B5, Canada. Electronic address: ytwang@brain.ubc.ca., Yamamoto T; Department of Molecular Neurobiology, Faculty of Medicine, Kagawa University, Miki-cho, Kagawa 761-0793, Japan. Electronic address: tohru@med.kagawa-u.ac.jp., Craig AM; Brain Research Centre and Department of Psychiatry, University of British Columbia, Vancouver, BC V6T 2B5, Canada. Electronic address: acraig@mail.ubc.ca.

Publikováno v: Neuron [Neuron] 2016 Sep 07; Vol. 91 (5), pp. 1052-1068.