Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Ammen P. Sandhu"'
Autor:
Pieter R. Cullis, Ivan R. Nabi, Ammen P. Sandhu, Marco A. Ciufolini, Yuen Yi C. Tam, Sam Chen, Paulo J.C. Lin, Ismail M. Hafez
Publikováno v:
Nanomedicine: Nanotechnology, Biology and Medicine. 9:233-246
The in vivo gene silencing potencies of lipid nanoparticle (LNP)-siRNA systems containing the ionizable cationic lipids DLinDAP, DLinDMA, DLinKDMA, or DLinKC2-DMA can differ by three orders of magnitude. In this study, we examine the uptake and intra
Autor:
Ammen P. Sandhu, Scott A Barros, William Cantley, Ying K. Tam, Masuna Srinivasulu, Verbena Kosovrasti, Akin Akinc, Kieu Lam, Kallanthottathil G. Rajeev, Marco A. Ciufolini, Dinah W.Y. Sah, Soma De, Lloyd Jeffs, Ismail M. Hafez, Qingmin Chen, Thomas D. Madden, Antonin de Fougerolles, Ed Yaworski, June Qin, Mark A Tracy, Pieter R. Cullis, Barbara L. Mui, Jianxin Chen, Michael J. Hope, Martin Maier, Sandra K. Klimuk, Rene Alvarez, Connie K Cho, Michael J Weinstein, Muthiah Manoharan, Kim F. Wong, Mikameh Kazem, Derrick Stebbing, Merete L. Eisenhardt, Ian MacLachlan, Lubomir Nechev, Erin J Crosley, Muthusamy Jayaraman, J. Robert Dorkin, Sean C. Semple, Todd Borland
Publikováno v:
Nature Biotechnology. 28:172-176
We adopted a rational approach to design cationic lipids for use in formulations to deliver small interfering RNA (siRNA). Starting with the ionizable cationic lipid 1,2-dilinoleyloxy-3-dimethylaminopropane (DLinDMA), a key lipid component of stable
Autor:
Angela M. Lam, David B. Fenske, Ammen P. Sandhu, Lorne R. Palmer, Pieter R. Cullis, Michael V. Johnston
Publikováno v:
Analytical Biochemistry. 341:156-164
Previous work from this laboratory has shown that plasmid DNA can be encapsulated in small (70-nm-diameter) stabilized plasmid–lipid particles (SPLP) that consist of a single plasmid encapsulated within a bilayer lipid vesicle. SPLP preferentially
Autor:
Deirdre McIntosh, Pieter R. Cullis, David A. Tirrell, Peter Scherrer, Ammen P. Sandhu, Jungsoo Kim, Yuehua He, Tao Chen, David B. Fenske
Publikováno v:
Molecular membrane biology. 21(6)
Poly(ethylacrylic acid) (PEAA) is a pH-sensitive polymer that undergoes a transition from a hydrophilic to a hydrophobic form as the pH is lowered from neutral to acidic values. In this work we show that pH sensitive liposomes capable of intracellula